Pharmacologic Ascorbate Radiosensitizes Pancreatic Cancer but Radioprotects Normal Tissue: The Role of Oxidative Stress-Induced Lipid Peroxidation.

Autor: Chen GY; Departments of Surgery, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA., O'Leary BR; Departments of Surgery, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA.; Free Radical and Radiation Biology Division, Department of Radiation Oncology, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA., Du J; Departments of Surgery, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA.; Free Radical and Radiation Biology Division, Department of Radiation Oncology, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA., Carroll RS; Departments of Surgery, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA., Steers GJ; Departments of Surgery, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA., Buettner GR; Free Radical and Radiation Biology Division, Department of Radiation Oncology, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA., Cullen JJ; Departments of Surgery, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA.; Free Radical and Radiation Biology Division, Department of Radiation Oncology, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA.

Publikováno v: Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2024 Mar 18; Vol. 13 (3). Date of Electronic Publication: 2024 Mar 18.

Pharmacological Ascorbate Enhances Chemotherapies in Pancreatic Ductal Adenocarcinoma.

Autor: O'Leary BR, Ruppenkamp EK; From the Department of Surgery., Steers GJ; From the Department of Surgery., Du J; From the Department of Surgery., Carroll RS; From the Department of Surgery., Wagner BA; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Carver College of Medicine, Iowa City, IA., Buettner GR; Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Carver College of Medicine, Iowa City, IA., Cullen JJ

Publikováno v: Pancreas [Pancreas] 2022 Jul 01; Vol. 51 (6), pp. 684-693. Date of Electronic Publication: 2022 Sep 13.

Impact of EcSOD Perturbations in Cancer Progression.

Autor: O'Leary BR; Department of Surgery, University of Iowa College of Medicine, Iowa City, IA 52246, USA., Carroll RS; Department of Surgery, University of Iowa College of Medicine, Iowa City, IA 52246, USA., Steers GJ; Department of Surgery, University of Iowa College of Medicine, Iowa City, IA 52246, USA., Hrabe J; Department of Surgery, University of Iowa College of Medicine, Iowa City, IA 52246, USA., Domann FE; Department of Radiation Oncology, University of Iowa College of Medicine, Iowa City, IA 52246, USA.; Holden Comprehensive Cancer Center, Iowa City, IA 52246, USA., Cullen JJ; Department of Surgery, University of Iowa College of Medicine, Iowa City, IA 52246, USA.; Department of Radiation Oncology, University of Iowa College of Medicine, Iowa City, IA 52246, USA.; Holden Comprehensive Cancer Center, Iowa City, IA 52246, USA.; Veterans Affairs Medical Center, Iowa City, IA 52246, USA.

Publikováno v: Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2021 Jul 29; Vol. 10 (8). Date of Electronic Publication: 2021 Jul 29.

Catalase Modulates the Radio-Sensitization of Pancreatic Cancer Cells by Pharmacological Ascorbate.

Autor: Du J; Free Radical and Radiation Biology Program, Department of Radiation Oncology, The University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.; Department of Surgery, The University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA., Carroll RS; Free Radical and Radiation Biology Program, Department of Radiation Oncology, The University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.; Department of Surgery, The University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA., Steers GJ; Free Radical and Radiation Biology Program, Department of Radiation Oncology, The University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.; Department of Surgery, The University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA., Wagner BA; Department of Surgery, The University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA., O'Leary BR; Free Radical and Radiation Biology Program, Department of Radiation Oncology, The University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.; Department of Surgery, The University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA., Jensen CS; Department of Pathology, The University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA., Buettner GR; Department of Surgery, The University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA., Cullen JJ; Free Radical and Radiation Biology Program, Department of Radiation Oncology, The University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.; Department of Surgery, The University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.

Publikováno v: Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2021 Apr 16; Vol. 10 (4). Date of Electronic Publication: 2021 Apr 16.