Phenotyping hepatocellular metabolism using uniformly labeled carbon-13 molecular probes and LC-HRMS stable isotope tracing.

Autor: Meissen JK; Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., 558 Eastern Point Road, Groton, CT 06340, USA., Pirman DA; Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., 558 Eastern Point Road, Groton, CT 06340, USA., Wan M; Cardiovascular and Metabolic Diseases Research Unit, Pfizer, Inc., 610 Main Street, Cambridge, MA 02139, USA., Miller E; Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., 558 Eastern Point Road, Groton, CT 06340, USA., Jatkar A; Cardiovascular and Metabolic Diseases Research Unit, Pfizer, Inc., 610 Main Street, Cambridge, MA 02139, USA., Miller R; Cardiovascular and Metabolic Diseases Research Unit, Pfizer, Inc., 610 Main Street, Cambridge, MA 02139, USA., Steenwyk RC; Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., 558 Eastern Point Road, Groton, CT 06340, USA., Blatnik M; Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., 558 Eastern Point Road, Groton, CT 06340, USA. Electronic address: matthew.blatnik@pfizer.com.

Publikováno v: Analytical biochemistry [Anal Biochem] 2016 Sep 01; Vol. 508, pp. 129-37. Date of Electronic Publication: 2016 Jun 23.

Ultra sensitive measurement of endogenous epinephrine and norepinephrine in human plasma by semi-automated SPE-LC-MS/MS.

Autor: Zhang G; Biomarker Research, PDM, PGRD, Pfizer Inc., Groton, CT 06340, USA., Zhang Y, Ji C, McDonald T, Walton J, Groeber EA, Steenwyk RC, Lin Z

Publikováno v: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2012 May 01; Vol. 895-896, pp. 186-90. Date of Electronic Publication: 2012 Mar 26.

Quantification of urinary PGEm, 6-keto PGF(1alpha) and 2,3-dinor-6-keto PGF(1alpha) by UFLC-MS/MS before and after exercise.

Autor: Blatnik M; Department of Pharmacokinetics, Dynamics & Metabolism, Pfizer Global Research and Development, Groton Laboratories. Eastern Point Rd, Groton, CT 06340, USA. matthew.blatnik@pfizer.com, Steenwyk RC

Publikováno v: Prostaglandins & other lipid mediators [Prostaglandins Other Lipid Mediat] 2010 Sep; Vol. 93 (1-2), pp. 8-13. Date of Electronic Publication: 2010 Apr 21.

Comparison of fused-core and conventional particle size columns by LC-MS/MS and UV: application to pharmacokinetic study.

Autor: Song W; Pharmacokinetics, Dynamics and Metabolism, Pfizer Global R&D, Groton, CT 06340, USA. wei.song2@pfizer.com, Pabbisetty D, Groeber EA, Steenwyk RC, Fast DM

Publikováno v: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2009 Oct 15; Vol. 50 (3), pp. 491-500. Date of Electronic Publication: 2009 May 22.

Mechanism-based inactivation of cytochrome P450 2D6 by 1-[(2-ethyl-4-methyl-1H-imidazol-5-yl)methyl]- 4-[4-(trifluoromethyl)-2-pyridinyl]piperazine: kinetic characterization and evidence for apoprotein adduction.

Autor: Hutzler JM; Pfizer, Pharmacokinetics, Dynamics, and Metabolism (PDM), St. Louis, Missouri, USA., Steenwyk RC, Smith EB, Walker GS, Wienkers LC

Publikováno v: Chemical research in toxicology [Chem Res Toxicol] 2004 Feb; Vol. 17 (2), pp. 174-84.