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Akademický článek

Piperazine-based CCR5 antagonists as HIV-1 inhibitors. II. Discovery of 1-[(2,4-dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(S)-methyl-4-[1(S)-[4-(trifluoromethyl)phenyl]ethyl]-1-piperazinyl]- piperidine N1-oxide (Sch-350634), an orally bioavailable, potent CCR5 antagonist.

Autor: Tagat JR; Departments of Chemical Research, Drug Metabolism & Pharmacokinetics, and Antiviral Therapy, Schering-Plough Research Institute, K-15-2B-2800, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA. jayaram.tagat@spcorp.com, Steensma RW, McCombie SW, Nazareno DV, Lin SI, Neustadt BR, Cox K, Xu S, Wojcik L, Murray MG, Vantuno N, Baroudy BM, Strizki JM

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2001 Oct 11; Vol. 44 (21), pp. 3343-6.

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Estimation of maximum recommended therapeutic dose of anti-retroviral drugs using diversified sampling and varied descriptors.

Autor: SAHU, Roopshikha¹, YADAV, Amisha¹, NATH, Abhigyan¹ abhigyannath01@gmail.com

Publikováno v: Minerva Biotechnology & Biomolecular Research. Dec2021, Vol. 33 Issue 4, p210-218. 9p.

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Drug metabolic stability in early drug discovery to develop potential lead compounds.

Autor: Gajula, Siva Nageswara Rao¹ (AUTHOR), Nadimpalli, Nimisha¹ (AUTHOR), Sonti, Rajesh¹ (AUTHOR)

Publikováno v: Drug Metabolism Reviews. Aug 2021, Vol. 53 Issue 3, p459-477. 19p.

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Exploring chalcone-sulfonyl piperazine hybrids as anti-diabetes candidates: design, synthesis, biological evaluation, and molecular docking study.

Autor: Hosseini Nasab N; Department of Biological Sciences, College of Natural Sciences, Kongju National University, Gongju, 32588, Republic of Korea.; College of Pharmacy, Chungbuk National University, Cheongju, 28160, Republic of Korea., Raza H; Department of Biological Sciences, College of Natural Sciences, Kongju National University, Gongju, 32588, Republic of Korea., Eom YS; Department of Biological Sciences, College of Natural Sciences, Kongju National University, Gongju, 32588, Republic of Korea., Shah FH; Department of Biological Sciences, College of Natural Sciences, Kongju National University, Gongju, 32588, Republic of Korea., Kwak JH; College of Pharmacy, Chungbuk National University, Cheongju, 28160, Republic of Korea., Kim SJ; Department of Biological Sciences, College of Natural Sciences, Kongju National University, Gongju, 32588, Republic of Korea. ksj85@kongju.ac.kr.

Publikováno v: Molecular diversity [Mol Divers] 2024 May 22. Date of Electronic Publication: 2024 May 22.

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