To Modify or Not to Modify: Allele‐Specific Effects of 3'UTR‐KCNQ1 Single Nucleotide Polymorphisms on Clinical Phenotype in a Long QT 1 Founder Population Segregating a Dominant‐Negative Mutation

Autor: Annika Winbo, Ulla‐Britt Diamant, Johan Persson, Steen M. Jensen, Annika Rydberg

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 18 (2022)

Background There are conflicting reports with regard to the allele‐specific gene suppression effects of single nucleotide polymorphisms (SNPs) in the 3'untranslated region (3'UTR) of the KCNQ1 gene in long QT syndrome type 1 (LQT1) populations. Her

Externí odkaz: https://doaj.org/article/ba1ec9b1125e4572b1db0969dcdb8ee9

Sex is a moderator of the association between NOS1AP sequence variants and QTc in two long QT syndrome founder populations: a pedigree-based measured genotype association analysis

Autor: Annika Winbo, Eva-Lena Stattin, Ida Maria Westin, Anna Norberg, Johan Persson, Steen M. Jensen, Annika Rydberg

Publikováno v: BMC Medical Genetics, Vol 18, Iss 1, Pp 1-9 (2017)

Abstract Background Sequence variants in the NOS1AP gene have repeatedly been reported to influence QTc, albeit with moderate effect sizes. In the long QT syndrome (LQTS), this may contribute to the substantial QTc variance seen among carriers of ide

Externí odkaz: https://doaj.org/article/e142399726f84005ad0c4e2caebdedb4

ICD harm and benefit: risk scores applied to the Swedish ICD-treated LQTS population

Autor: Emilia Sundström, Steen M. Jensen, Ulla-Britt Diamant, Urban Wiklund, Annika Rydberg

Objectives. The use of implantable cardioverter defibrillators (ICDs) in long QT syndrome (LQTS) patients is essential in high-risk patients. However, it is sometimes used in patients without high-risk profiles for whom the expected benefit may be lo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f23ccd67ba4cd2185058dbaf867201f
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-194538

Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes

Autor: Erkki Vartiainen, Julie K K Vishram-Nielsen, Stefan Söderberg, Jukka Kontto, Christina Magnussen, Simona Costanzo, Blankenberg Stefan, Augusto Di Castelnuovo, Kari Kuulasmaa, Torben Jørgensen, Wolfgang Koenig, Steen M. Jensen, Stephan Camen, Ellisiv B. Mathiesen, Maja-Lisa Løchen, Veikko Salomaa, Licia Iacoviello, Frank Kee, Giovanni de Gaetano, Francesco Gianfagna, Renate B. Schnabel, Teemu J. Niiranen, Tanja Zeller, Ngoc-Anh Sprünker, Maria Benedetta Donati, Dora Csengeri

Publikováno v: Csengeri, D, Sprunker, N-A, Di Castelnuovo, A, Niiranen, T, Vishram-Nielsen, J K, Costanzo, S, Soderberg, S, Jensen, S M, Vartiainen, E, Donati, M B, Magnussen, C, Camen, S, Gianfagna, F, Lochen, M-L, Kee, F, Kontto, J, Mathiesen, E B, Koenig, W, Stefan, B, de Gaetano, G, Jorgensen, T, Kuulasmaa, K, Zeller, T, Salomaa, V, Iacoviello, L & Schnabel, R B 2021, ' Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes ', European Heart Journal, vol. 42, no. 12, pp. 1170-1177 . https://doi.org/10.1093/eurheartj/ehaa953
Csengeri, D, Sprünker, N-A, Di Castelnuovo, A, Niiranen, T, Vishram-Nielsen, J K, Costanzo, S, Söderberg, S, Jensen, S M, Vartiainen, E, Donati, M B, Magnussen, C, Camen, S, Gianfagna, F, Løchen, M-L, Kee, F, Kontto, J, Mathiesen, E B, Koenig, W, Stefan, B, de Gaetano, G, Jørgensen, T, Kuulasmaa, K, Zeller, T, Salomaa, V, Iacoviello, L & Schnabel, R B 2021, ' Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes ', European Heart Journal . https://doi.org/10.1093/eurheartj/ehaa953
European Heart Journal
Csengeri, D, Sprünker, N-A, Di Castelnuovo, A, Niiranen, T, Vishram-Nielsen, J K, Costanzo, S, Söderberg, S, Jensen, S M, Vartiainen, E, Donati, M B, Magnussen, C, Camen, S, Gianfagna, F, Løchen, M-L, Kee, F, Kontto, J, Mathiesen, E B, Koenig, W, Stefan, B, de Gaetano, G, Jørgensen, T, Kuulasmaa, K, Zeller, T, Salomaa, V, Iacoviello, L & Schnabel, R B 2021, ' Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes ', European Heart Journal, vol. 42, no. 12, pp. 1170-1177 . https://doi.org/10.1093/eurheartj/ehaa953

Aims There is inconsistent evidence on the relation of alcohol intake with incident atrial fibrillation (AF), in particular at lower doses. We assessed the association between alcohol consumption, biomarkers, and incident AF across the spectrum of al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4adc8a426a0c504c1eeb34ff4f847dd8
https://curis.ku.dk/portal/da/publications/alcohol-consumption-cardiac-biomarkers-and-risk-of-atrial-fibrillation-and-adverse-outcomes(3efbf0dc-2de6-463f-8ebc-ff8fd35e3f68).html

Epirubicin-induced QT prolongation, monomorphic ventricular tachycardia, and response to beta blockade in long QT syndrome type 2

Autor: Steen M. Jensen, Ylva Holmgren Stenlund, Milos Kesek

Publikováno v: HeartRhythm Case Reports

Congenital long QT syndrome (LQTS) is a group of cardiac channelopathies that are manifested through changes in repolarization. Patients are at increased risk of malignant ventricular arrhythmia, triggered by early afterdepolarization (EAD).1 The pri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41477d413d43293fe1feaf63cd7d0f9e
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-197930