Zobrazeno 1 - 10 of 301 pro vyhledávání: '"Steen B Pedersen"'
1
Akademický článek
Characterization of immortalized human brown and white pre-adipocyte cell models from a single donor.
Autor: Lasse K Markussen, Marie S Isidor, Peter Breining, Elise S Andersen, Nanna E Rasmussen, Louise I Petersen, Steen B Pedersen, Bjørn Richelsen, Jacob B Hansen
Publikováno v: PLoS ONE, Vol 12, Iss 9, p e0185624 (2017)
Brown adipose tissue with its constituent brown adipocytes is a promising therapeutic target in metabolic disorders due to its ability to dissipate energy and improve systemic insulin sensitivity and glucose homeostasis. The molecular control of brow
Externí odkaz: https://doaj.org/article/513cc2155bee4d318768f670f48db773
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2
Akademický článek
LPS-Enhanced Glucose-Stimulated Insulin Secretion Is Normalized by Resveratrol.
Autor: Mark K Nøhr, Anete Dudele, Morten M Poulsen, Lene H Ebbesen, Yulia Radko, Lars P Christensen, Niels Jessen, Bjørn Richelsen, Sten Lund, Steen B Pedersen
Publikováno v: PLoS ONE, Vol 11, Iss 1, p e0146840 (2016)
UNLABELLED:Low-grade inflammation is seen with obesity and is suggested to be a mediator of insulin resistance. The eliciting factor of low-grade inflammation is unknown but increased permeability of gut bacteria-derived lipopolysaccharides (LPS) res
Externí odkaz: https://doaj.org/article/6395f426dfa54c5c9cd430ea2db90816
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3
Akademický článek
SILAC-MS Based Characterization of LPS and Resveratrol Induced Changes in Adipocyte Proteomics - Resveratrol as Ameliorating Factor on LPS Induced Changes.
Autor: Mark K Nøhr, Toke P Kroager, Kristian W Sanggaard, Anders D Knudsen, Allan Stensballe, Jan J Enghild, Jens Ølholm, Bjørn Richelsen, Steen B Pedersen
Publikováno v: PLoS ONE, Vol 11, Iss 7, p e0159747 (2016)
Adipose tissue inflammation is believed to play a pivotal role in the development obesity-related morbidities such as insulin resistance. However, it is not known how this (low-grade) inflammatory state develops. It has been proposed that the leakage
Externí odkaz: https://doaj.org/article/c421067a3d704037b21c219479ff853b
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4
Akademický článek
Evaluation of functional erythropoietin receptor status in skeletal muscle in vivo: acute and prolonged studies in healthy human subjects.
Autor: Britt Christensen, Carsten Lundby, Niels Jessen, Thomas S Nielsen, Poul F Vestergaard, Niels Møller, Henriette Pilegaard, Steen B Pedersen, John J Kopchick, Jens Otto L Jørgensen
Publikováno v: PLoS ONE, Vol 7, Iss 2, p e31857 (2012)
BackgroundErythropoietin receptors have been identified in human skeletal muscle tissue, but downstream signal transduction has not been investigated. We therefore studied in vivo effects of systemic erythropoietin exposure in human skeletal muscle.M
Externí odkaz: https://doaj.org/article/beb3bcdc00064017b631103d3a01a457
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5
Akademický článek
Insulin and GH signaling in human skeletal muscle in vivo following exogenous GH exposure: impact of an oral glucose load.
Autor: Thomas Krusenstjerna-Hafstrøm, Michael Madsen, Mikkel H Vendelbo, Steen B Pedersen, Jens S Christiansen, Niels Møller, Niels Jessen, Jens O L Jørgensen
Publikováno v: PLoS ONE, Vol 6, Iss 5, p e19392 (2011)
GH induces acute insulin resistance in skeletal muscle in vivo, which in rodent models has been attributed to crosstalk between GH and insulin signaling pathways. Our objective was to characterize time course changes in signaling pathways for GH and
Externí odkaz: https://doaj.org/article/0b1827b1481e4c6cb3dfce6f21da90d7
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6
Whole-body and forearm muscle protein metabolism in patients with acromegaly before and after treatment
Autor: Mai C Arlien-Søborg, Jakob Dal, Michael Alle Madsen, Morten Lyng Høgild, Steen B Pedersen, Niels Jessen, Jens O L Jørgensen, Niels Møller
Publikováno v: Arlien-Søborg, M C, Dal, J, Madsen, M A, Høgild, M L, Pedersen, S B, Jessen, N, Jørgensen, J O L & Møller, N 2023, ' Whole-body and forearm muscle protein metabolism in patients with acromegaly before and after treatment ', Journal of Clinical Endocrinology and Metabolism . https://doi.org/10.1210/clinem/dgad190
Arlien-Søborg, M C, Dal, J, Madsen, M A, Høgild, M L, Pedersen, S B, Jessen, N, Jørgensen, J O L & Møller, N 2023, ' Whole-body and forearm muscle protein metabolism in patients with acromegaly before and after treatment ', The Journal of clinical endocrinology and metabolism . https://doi.org/10.1210/clinem/dgad190
Background: Active acromegaly is characterized by increased lean body mass but the mechanisms underlying the protein anabolic effect are unclear.Aim: To study if active acromegaly induces reversible changes in whole-body and skeletal muscle protein k
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae7e0f90a2931119dd2212b1ef23491a
https://vbn.aau.dk/da/publications/e3e00c39-2942-4d64-841a-e25a1859266a
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7
Parathyroid hormone receptor stimulation induces human adipocyte lipolysis and browning
Autor: Niels Jessen, Bjørn Richelsen, Steen B. Pedersen, Peter Breining, Jacob B. Hansen, Mads Kjolby
Publikováno v: Breining, P, Pedersen, S B, Kjolby, M, Hansen, J B, Jessen, N & Richelsen, B 2021, ' Parathyroid hormone receptor stimulation induces human adipocyte lipolysis and browning ', European Journal of Endocrinology, vol. 184, no. 5, pp. 687-697 . https://doi.org/10.1530/EJE-20-0713
Objective Activation of brown adipose tissue is a promising strategy to treat and prevent obesity and obesity-related disorders. Activation of uncoupling protein 1 (UCP1) leads to uncoupled respiration and dissipation of stored energy as heat. Induct
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9393d6212f2abdcb21a7db48ea58f29
https://doi.org/10.1530/eje-20-0713
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9
Sex chromosome aneuploidies give rise to changes in the circular RNA profile: A circular transcriptome-wide study of Turner and Klinefelter syndrome across different tissues
Autor: Emma B. Johannsen, Jesper Just, Mette H. Viuff, Trine Line Hauge Okholm, Steen B. Pedersen, Katrine Meyer Lauritsen, Christian Trolle, Mette Glavind Bülow Pedersen, Simon Chang, Jens Fedder, Anne Skakkebæk, Claus H. Gravholt
Publikováno v: Johannsen, E M B, Just, J, Viuff, M H, Okholm, T L H, Pedersen, S B, Meyer Lauritsen, K, Trolle, C, Pedersen, M G B, Chang, S, Fedder, J, Skakkebæk, A & Gravholt, C H 2022, ' Sex chromosome aneuploidies give rise to changes in the circular RNA profile : A circular transcriptome-wide study of Turner and Klinefelter syndrome across different tissues ', Frontiers in Genetics, vol. 13, 928874 . https://doi.org/10.3389/fgene.2022.928874
Purpose: The landscape of circular RNAs (circRNAs), an important class of non-coding RNAs that regulate gene expression, has never been described in human disorders of sex chromosome aneuploidies. We profiled circRNAs in Turner syndrome females (45,X
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2684b40cc07c805bb4ebef0f85687cfc
https://pubmed.ncbi.nlm.nih.gov/35938026
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10
Insulin resistance induced by growth hormone is linked to lipolysis and associated with suppressed pyruvate dehydrogenase activity in skeletal muscle: a 2 × 2 factorial, randomised, crossover study in human individuals
Autor: Niels Møller, Jens Otto Lunde Jørgensen, Julian L. Griffin, Niels Jessen, Henriette Pilegaard, Astrid Johannesson Hjelholt, Anders Gudiksen, Steen B. Pedersen, Evelina Charidemou
Publikováno v: Hjelholt, A J, Charidemou, E, Griffin, J L, Pedersen, S B, Gudiksen, A, Pilegaard, H, Jessen, N, Møller, N & Jørgensen, J O L 2020, ' Insulin resistance induced by growth hormone is linked to lipolysis and associated with suppressed pyruvate dehydrogenase activity in skeletal muscle : a 2x2 factorial, randomised, crossover study in human individuals ', Diabetologia, vol. 63, no. 12, pp. 2641-2653 . https://doi.org/10.1007/s00125-020-05262-w
AIMS/HYPOTHESIS: Growth hormone (GH) causes insulin resistance that is linked to lipolysis, but the underlying mechanisms are unclear. We investigated if GH-induced insulin resistance in skeletal muscle involves accumulation of diacylglycerol (DAG) a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebff42013fe5e3857573fa9b1ae9af55
https://doi.org/10.1007/s00125-020-05262-w
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