X chromosome dosage and the genetic impact across human tissues

Autor: Mette Viuff, Anne Skakkebæk, Emma B. Johannsen, Simon Chang, Steen Bønlykke Pedersen, Katrine Meyer Lauritsen, Mette Glavind Bülow Pedersen, Christian Trolle, Jesper Just, Claus H. Gravholt

Publikováno v: Genome Medicine, Vol 15, Iss 1, Pp 1-19 (2023)

Abstract Background Sex chromosome aneuploidies (SCAs) give rise to a broad range of phenotypic traits and diseases. Previous studies based on peripheral blood samples have suggested the presence of ripple effects, caused by altered X chromosome numb

Externí odkaz: https://doaj.org/article/db4f75ab2f61487782271ccbb0b67421

Expression Patterns and Correlations with Metabolic Markers of Zinc Transporters ZIP14 and ZNT1 in Obesity and Polycystic Ovary Syndrome

Autor: Trine Maxel, Pernille Fog Svendsen, Steen Bønlykke Pedersen, Jørgen Rungby, Jesper Krogh Lauridsen, Agnete Larsen, Birgitte Brock, Kamille Smidt

Publikováno v: Maxel, T, Svendsen, P F, Smidt, K, Lauridsen, J K, Brock, B, Pedersen, S B, Rungby, J & Larsen, A 2017, ' Expression Patterns and Correlations with Metabolic Markers of Zinc Transporters ZIP14 and ZNT1 in Obesity and Polycystic Ovary Syndrome ', Frontiers in Endocrinology, vol. 8, 38 . https://doi.org/10.3389/fendo.2017.00038

Polycystic ovary syndrome (PCOS) is associated with infertility, increased androgen levels and insulin resistance. In adipose tissue, zinc facilitates insulin signaling. Circulating zinc levels are altered in obesity, diabetes, and PCOS, and zinc sup

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb380f6f418b0d83a7f34c5f68a36be
https://doi.org/10.3389/fendo.2017.00038

Regulation of Lipolysis and Adipose Tissue Signaling during Acute Endotoxin-Induced Inflammation: A Human Randomized Crossover Trial

Autor: Niels Jessen, Henrik Holm Thomsen, Niels Møller, Steen Bønlykke Pedersen, Nikolaj Rittig, Thomas Sava Nielsen, Jens Otto Lunde Jørgensen, Ermina Bach

Publikováno v: PLoS ONE
PLoS ONE, Vol 11, Iss 9, p e0162167 (2016)
Rittig, N, Bach, E, Thomsen, H H, Pedersen, S B, Nielsen, T S, Jørgensen, J O L, Jessen, N & Møller, N 2016, ' Regulation of Lipolysis and Adipose Tissue Signaling during Acute Endotoxin-Induced Inflammation: A Human Randomized Crossover Trial ', P L o S One, vol. 11, no. 9, e0162167 . https://doi.org/10.1371/journal.pone.0162167

Background Lipolysis is accelerated during the acute phase of inflammation, a process being regulated by pro-inflammatory cytokines (e.g. TNF-α), stress-hormones, and insulin. The intracellular mechanisms remain elusive and we therefore measured pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5e216954e796617cb3edacb5cc214e6
https://doi.org/10.1371/journal.pone.0162167