Bicyclo((aryl)methyl)benzamides as inhibitors of GlyT1

Autor: Varnes, Jeffrey G., Xiong, Hui, Forst, Janet M., Holmquist, Christopher R., Ernst, Glen E., Frietze, William, Dembofsky, Bruce, Andisik, Don W., Palmer, William E., Hinkley, Lindsay, Steelman, Gary B., Wilkins, Deidre E., Tian, Gaochao, Jonak, Gerald, Potts, William M., Wang, Xia, Brugel, Todd A., Alhambra, Cristóbal, Wood, Michael W., Veale, Chris A., Albert, Jeffrey S.

Publikováno v: In Bioorganic & Medicinal Chemistry Letters 1 April 2018 28(6):1043-1049

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Efficient method for the synthesis of 1,4-disubstituted 5-carbomethoxypyrimidin-6-ones.

Autor: Veale, Chris A., Steelman, Gary B.

Publikováno v: Journal of Organic Chemistry; 7/30/93, Vol. 58 Issue 16, p4490, 4p, 1 Diagram, 2 Charts

Azepines and piperidines with dual norepinephrine dopamine uptake inhibition and antidepressant activity.

Autor: Brown DG; CNS Discovery Research, AstraZeneca Pharmaceuticals , 1800 Concord Pike, Wilmington, Delaware 19850-5437, United States., Bernstein PR; CNS Discovery Research, AstraZeneca Pharmaceuticals , 1800 Concord Pike, Wilmington, Delaware 19850-5437, United States., Wu Y; CNS Discovery Research, AstraZeneca Pharmaceuticals , 1800 Concord Pike, Wilmington, Delaware 19850-5437, United States., Urbanek RA; CNS Discovery Research, AstraZeneca Pharmaceuticals , 1800 Concord Pike, Wilmington, Delaware 19850-5437, United States., Becker CW; CNS Discovery Research, AstraZeneca Pharmaceuticals , 1800 Concord Pike, Wilmington, Delaware 19850-5437, United States., Throner SR; CNS Discovery Research, AstraZeneca Pharmaceuticals , 1800 Concord Pike, Wilmington, Delaware 19850-5437, United States., Dembofsky BT; CNS Discovery Research, AstraZeneca Pharmaceuticals , 1800 Concord Pike, Wilmington, Delaware 19850-5437, United States., Steelman GB; CNS Discovery Research, AstraZeneca Pharmaceuticals , 1800 Concord Pike, Wilmington, Delaware 19850-5437, United States., Lazor LA; CNS Discovery Research, AstraZeneca Pharmaceuticals , 1800 Concord Pike, Wilmington, Delaware 19850-5437, United States., Scott CW; CNS Discovery Research, AstraZeneca Pharmaceuticals , 1800 Concord Pike, Wilmington, Delaware 19850-5437, United States., Wood MW; CNS Discovery Research, AstraZeneca Pharmaceuticals , 1800 Concord Pike, Wilmington, Delaware 19850-5437, United States., Wesolowski SS; CNS Discovery Research, AstraZeneca Pharmaceuticals , 1800 Concord Pike, Wilmington, Delaware 19850-5437, United States., Nugiel DA; CNS Discovery Research, AstraZeneca Pharmaceuticals , 1800 Concord Pike, Wilmington, Delaware 19850-5437, United States., Koch S; CNS Discovery Research, AstraZeneca Pharmaceuticals , 1800 Concord Pike, Wilmington, Delaware 19850-5437, United States., Yu J; CNS Discovery Research, AstraZeneca Pharmaceuticals , 1800 Concord Pike, Wilmington, Delaware 19850-5437, United States., Pivonka DE; CNS Discovery Research, AstraZeneca Pharmaceuticals , 1800 Concord Pike, Wilmington, Delaware 19850-5437, United States., Li S; CNS Discovery Research, AstraZeneca Pharmaceuticals , 1800 Concord Pike, Wilmington, Delaware 19850-5437, United States., Thompson C; CNS Discovery Research, AstraZeneca Pharmaceuticals , 1800 Concord Pike, Wilmington, Delaware 19850-5437, United States., Zacco A; CNS Discovery Research, AstraZeneca Pharmaceuticals , 1800 Concord Pike, Wilmington, Delaware 19850-5437, United States., Elmore CS; CNS Discovery Research, AstraZeneca Pharmaceuticals , 1800 Concord Pike, Wilmington, Delaware 19850-5437, United States., Schroeder P; CNS Discovery Research, AstraZeneca Pharmaceuticals , 1800 Concord Pike, Wilmington, Delaware 19850-5437, United States., Liu J; CNS Discovery Research, AstraZeneca Pharmaceuticals , 1800 Concord Pike, Wilmington, Delaware 19850-5437, United States., Hurley CA; Argenta , 8/9 Spire Green Centre, Flex Meadow, Harlow, Essex, CM19 5TR, United Kingdom., Ward S; Argenta , 8/9 Spire Green Centre, Flex Meadow, Harlow, Essex, CM19 5TR, United Kingdom., Hunt HJ; Argenta , 8/9 Spire Green Centre, Flex Meadow, Harlow, Essex, CM19 5TR, United Kingdom., Williams K; Argenta , 8/9 Spire Green Centre, Flex Meadow, Harlow, Essex, CM19 5TR, United Kingdom., McLaughlin J; CNS Discovery Research, AstraZeneca Pharmaceuticals , 1800 Concord Pike, Wilmington, Delaware 19850-5437, United States., Hoesch V; CNS Discovery Research, AstraZeneca Pharmaceuticals , 1800 Concord Pike, Wilmington, Delaware 19850-5437, United States., Sydserff S; CNS Discovery Research, AstraZeneca Pharmaceuticals , 1800 Concord Pike, Wilmington, Delaware 19850-5437, United States., Maier D; CNS Discovery Research, AstraZeneca Pharmaceuticals , 1800 Concord Pike, Wilmington, Delaware 19850-5437, United States., Aharony D; CNS Discovery Research, AstraZeneca Pharmaceuticals , 1800 Concord Pike, Wilmington, Delaware 19850-5437, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2012 Nov 12; Vol. 4 (1), pp. 46-51. Date of Electronic Publication: 2012 Nov 12 (Print Publication: 2013).