IL-23 promotes TCR-mediated negative selection of thymocytes through the upregulation of IL-23 receptor and RORγt.

Autor: Li H; 1] Division of Clinical Immunology & Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA [2] Department Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA., Hsu HC; Division of Clinical Immunology & Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA., Wu Q; Division of Clinical Immunology & Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA., Yang P; Division of Clinical Immunology & Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA., Li J; Division of Clinical Immunology & Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA., Luo B; Division of Clinical Immunology & Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA., Oukka M; Department of Pediatrics, University of Washington, Seattle, Washington 98195, USA., Steele CH 3rd; Division of Pulmonary, Allergy & Critical Care, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA., Cua DJ; Merck Research Laboratories, Palo Alto, California 94304, USA., Grizzle WE; Clinical Pathology & Anatomic Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA., Mountz JD; 1] Division of Clinical Immunology & Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA [2] Birmingham VA Medical Center, Birmingham, Alabama 35233, USA.

Publikováno v: Nature communications [Nat Commun] 2014 Jul 08; Vol. 5, pp. 4259. Date of Electronic Publication: 2014 Jul 08.