B-cell precursor acute lymphoblastic leukemia elicits an interferon-α/β response in bone marrow-derived mesenchymal stroma.

Autor: Smeets MWE; Dept. of Pediatrics, Erasmus MC-Sophia, Rotterdam, The Netherlands; Princess Máxima Center for Pediatric Oncology, Utrecht., Steeghs EMP; Dept. of Pediatrics, Erasmus MC-Sophia, Rotterdam., Orsel J; Princess Máxima Center for Pediatric Oncology, Utrecht., Stalpers F; Princess Máxima Center for Pediatric Oncology, Utrecht., Vermeeren MMP; Princess Máxima Center for Pediatric Oncology, Utrecht., Veltman CHJ; Princess Máxima Center for Pediatric Oncology, Utrecht., Slenders L; Princess Máxima Center for Pediatric Oncology, Utrecht., Nierkens S; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands; Center for Translational Immunology, University Medical Center, Utrecht., Van de Ven C; Princess Máxima Center for Pediatric Oncology, Utrecht., Den Boer ML; Dept. of Pediatrics, Erasmus MC-Sophia, Rotterdam, The Netherlands; Princess Máxima Center for Pediatric Oncology, Utrecht. m.l.denboer@prinsesmaximacentrum.nl.

Publikováno v: Haematologica [Haematologica] 2024 Jul 01; Vol. 109 (7), pp. 2073-2084. Date of Electronic Publication: 2024 Jul 01.

Mutation-tailored treatment selection in non-small cell lung cancer patients in daily clinical practice.

Autor: Steeghs EMP; Department of Pathology, Radboudumc, Nijmegen, the Netherlands; Department of Pathology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, the Netherlands; Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands., Groen HJM; Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Schuuring E; Department of Pathology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Aarts MJ; Departments of Research & Development, Netherlands Comprehensive Cancer Organization (IKNL), Utrecht, the Netherlands., Damhuis RAM; Departments of Research & Development, Netherlands Comprehensive Cancer Organization (IKNL), Utrecht, the Netherlands., Voorham QJM; PALGA Foundation, Houten, the Netherlands., Ligtenberg MJL; Department of Pathology, Radboudumc, Nijmegen, the Netherlands; Department of Human Genetics, Radboudumc, Nijmegen, the Netherlands., Grünberg K; Department of Pathology, Radboudumc, Nijmegen, the Netherlands. Electronic address: Katrien.Grunberg@radboudumc.nl.

Publikováno v: Lung cancer (Amsterdam, Netherlands) [Lung Cancer] 2022 May; Vol. 167, pp. 87-97. Date of Electronic Publication: 2022 Apr 04.

Nationwide evaluation of mutation-tailored treatment of gastrointestinal stromal tumors in daily clinical practice.

Autor: Steeghs EMP; Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands., Gelderblom H; Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands., Ho VKY; Departments of Research and Development, Netherlands Comprehensive Cancer Organization (IKNL), Utrecht, The Netherlands., Voorham QJM; PALGA Foundation, Houten, The Netherlands., Willems SM; PALGA Foundation, Houten, The Netherlands.; Department of Pathology and Medical Biology, University Medical Center Groningen, Groningen, The Netherlands., Grünberg K; Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands., Ligtenberg MJL; Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands. Marjolijn.Ligtenberg@radboudumc.nl.; Laboratory of Tumor Genetics, Department of Pathology and Human Genetics, Radboud University Medical Center, Geert Grooteplein Zuid 10, PO Box 9101, 6500 HB, Nijmegen, The Netherlands. Marjolijn.Ligtenberg@radboudumc.nl.

Publikováno v: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association [Gastric Cancer] 2021 Sep; Vol. 24 (5), pp. 990-1002. Date of Electronic Publication: 2021 Apr 28.

Comprehensive routine diagnostic screening to identify predictive mutations, gene amplifications, and microsatellite instability in FFPE tumor material.

Autor: Steeghs EMP; Department of Pathology, Radboud university medical center, PO Box 9101, 6500, HB, Nijmegen, the Netherlands., Kroeze LI; Department of Pathology, Radboud university medical center, PO Box 9101, 6500, HB, Nijmegen, the Netherlands., Tops BBJ; Department of Pathology, Radboud university medical center, PO Box 9101, 6500, HB, Nijmegen, the Netherlands.; Department of Pathology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., van Kempen LC; Department of Pathology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Ter Elst A; Department of Pathology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Kastner-van Raaij AWM; Department of Pathology, Radboud university medical center, PO Box 9101, 6500, HB, Nijmegen, the Netherlands., Hendriks-Cornelissen SJB; Department of Pathology, Radboud university medical center, PO Box 9101, 6500, HB, Nijmegen, the Netherlands., Hermsen MJW; Department of Pathology, Radboud university medical center, PO Box 9101, 6500, HB, Nijmegen, the Netherlands., Jansen EAM; Department of Human Genetics, Radboud university medical center, Nijmegen, The Netherlands., Nederlof PM; Department of Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Schuuring E; Department of Pathology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Ligtenberg MJL; Department of Pathology, Radboud university medical center, PO Box 9101, 6500, HB, Nijmegen, the Netherlands.; Department of Human Genetics, Radboud university medical center, Nijmegen, The Netherlands., Eijkelenboom A; Department of Pathology, Radboud university medical center, PO Box 9101, 6500, HB, Nijmegen, the Netherlands. Astrid.Eijkelenboom@radboudumc.nl.

Publikováno v: BMC cancer [BMC Cancer] 2020 Apr 07; Vol. 20 (1), pp. 291. Date of Electronic Publication: 2020 Apr 07.

RAS pathway mutations as a predictive biomarker for treatment adaptation in pediatric B-cell precursor acute lymphoblastic leukemia.

Autor: Jerchel IS; Department of Pediatric Oncology, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands., Hoogkamer AQ; Department of Pediatric Oncology, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands., Ariës IM; Department of Pediatric Oncology, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands., Steeghs EMP; Department of Pediatric Oncology, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands., Boer JM; Department of Pediatric Oncology, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands., Besselink NJM; Center for Personalized Cancer Treatment (CPCT), University Medical Center Utrecht, Utrecht, The Netherlands.; Center for Molecular Medicine and Cancer Genomics Netherlands, Division Biomedical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands., Boeree A; Department of Pediatric Oncology, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands., van de Ven C; Department of Pediatric Oncology, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands., de Groot-Kruseman HA; DCOG, The Hague, The Netherlands., de Haas V; DCOG, The Hague, The Netherlands.; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Horstmann MA; Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; On behalf of the COALL., Escherich G; Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; On behalf of the COALL., Zwaan CM; Department of Pediatric Oncology, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands., Cuppen E; Center for Personalized Cancer Treatment (CPCT), University Medical Center Utrecht, Utrecht, The Netherlands.; Center for Molecular Medicine and Cancer Genomics Netherlands, Division Biomedical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands., Koudijs MJ; Center for Personalized Cancer Treatment (CPCT), University Medical Center Utrecht, Utrecht, The Netherlands.; Center for Molecular Medicine and Cancer Genomics Netherlands, Division Biomedical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands., Pieters R; DCOG, The Hague, The Netherlands.; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., den Boer ML; Department of Pediatric Oncology, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands.; DCOG, The Hague, The Netherlands.

Publikováno v: Leukemia [Leukemia] 2018 Apr; Vol. 32 (4), pp. 931-940. Date of Electronic Publication: 2017 Oct 03.