Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Steeg, E. van de"'
1
A higher throughput and physiologically relevant two-compartmental human ex vivo intestinal tissue system for studying gastrointestinal processes
Autor: Stevens, L.J., Lipzig M.M.H. van, Erpelinck, S.L.A., Pronk, A., Gorp J. van, Wortelboer, H.M., Steeg, E. van de
Publikováno v: European Journal of Pharmaceutical Sciences, 104989, 137
A majority of the preclinical intestinal screening models do not properly reflect the complex physiology of the human intestinal tract, resulting in low translational value to the clinical situation. The often used cell lines such as Caco-2 or HT-29
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::178e7222d9f0466f3057f6ad4add7f16
http://resolver.tudelft.nl/uuid:68e83f15-b862-4c40-841f-e23fe35c952c
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2
Monitoring the bio nanomechanical properties of cell structures
Autor: Heiden, M.S. van der, Tejeda, H., Rajadurai, S.R.S., Donkers, T., Duivenvoorde, T.L.P., Eslami Amirabadi, H., Ananth, A.N., Lucas, P., Steeg, E. van de
Publikováno v: SID Semicon Innovation Day, Science Centre Delft, 21 May 2019
Organ-on-chip technology is based on tissues or (stem)cell derived organ mimicking structures and in microfluidic systems. This technology is used to monitor functional response to stimuli, aiming to enable personalized medicine and to conduct pre-cl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::933555bcb1b668f77bfe82cb0a8472ff
http://resolver.tudelft.nl/uuid:13d8b020-fbcf-4b93-8fd8-92d92b099c3c
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4
Development of a mechanistic biokinetic model for hepatic bile acid handling to predict possible cholestatic effects of drugs
Autor: Notenboom, S., Weigand, K.M., Proost, J.H., Lipzig, M.M.H. van, Steeg, E. van de, Broek, P.H.H. van den, Greupink, R., Russel, F.G.M., Groothuis, G.M.M.
Publikováno v: European Journal of Pharmaceutical Sciences, 115, 175-184
Drug-induced liver injury (DILI) is a common reason for drug withdrawal from the market. An important cause of DILI is drug-induced cholestasis. One of the major players involved in drug-induced cholestasis is the bile salt efflux pump (BSEP; ABCB11)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4c630410b5d309151c58c8533b0bdceb
http://resolver.tudelft.nl/uuid:0039097c-78d6-40a4-b901-df30d53d188f
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5
ERP organ-function on a chip in 2017
Autor: Hanemaaijer, R., Steeg, E. van de, Bobeldijk, I., Ostendorf, R.
Over the last 4 years, the ERP Organ function on-a-chip evolved from a seed ERP (2015) into a full ERP (in 2016) and is still further growing towards 2018. The program has three use cases: gut-, liver- and lung-function on a chip. In addition nano-de
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::0fa37813345d0f9b45f07b73cf5f5753
http://resolver.tudelft.nl/uuid:21166b99-134b-4024-8b04-b28dd8df051c
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6
ERP organ-function on a chip in 2017
Autor: Hanemaaijer, R., Steeg, E. van de, Bobeldijk, I., Ostendorf, R.
Over the last 4 years, the ERP Organ function on-a-chip evolved from a seed ERP (2015) into a full ERP (in 2016) and is still further growing towards 2018. The program has three use cases: gut-, liver- and lung-function on a chip. In addition nano-de
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10718::6c51901dee65211375810401bc7e5235
http://resolver.tudelft.nl/uuid:21166b99-134b-4024-8b04-b28dd8df051c
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7
Regional expression levels of drug transporters and metabolizing enzymes along the pig and human intestinal tract and comparison with Caco-2 cells
Autor: Vaessen, S.F.C., Lipzig, M.M.H. van, Pieters, R.H.H., Krul, C.A.M., Wortelboer, H.M., Steeg, E. van de
Publikováno v: Drug Metabolism and Disposition, 4, 45, 353-360
Intestinal transporter proteins and metabolizing enzymes play a crucial role in the oral absorption of a wide variety of drugs. The aim of the current study was to characterize better available intestinal in vitro models by comparing expression level
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::54d7af50d0f179d7795cd5b2d76331a7
http://resolver.tudelft.nl/uuid:48bafffb-6f20-4569-a343-7edf003ca058
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8
The consequence of regional gradients of P-gp and CYP3A4 for drug-drug interactions by P-gp inhibitors and the P-gp/CYP3A4 interplay in the human intestine ex vivo
Autor: Li, M., Graaf, I.A.M. de, Steeg, E. van de, Jager, M.H. de, Groothuis, G.M.M.
Publikováno v: Toxicology in Vitro, 40, 26-33
Intestinal P-gp and CYP3A4 work coordinately to reduce the intracellular concentration of drugs, and drug-drug interactions (DDIs) based on this interplay are of clinical importance and require pre-clinical investigation. Using precision-cut intestin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::47b4fb06d2cb8e1dc66938529a9c9e66
http://resolver.tudelft.nl/uuid:1605cb45-53b9-45df-b0fe-3270559991e7
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9
Comparison of in vitro assays in selecting radiotracers for in vivo P-glycoprotein PET imaging
Autor: Raaphorst, R.M., Savolainen, H., Cantore, M., Steeg, E. van de, Waarde, A. van, Colabufo, N.A., Elsinga, P.H., Lammertsma, A.A., Windhorst, A.D., Luurtsema, G.
Publikováno v: Pharmaceuticals, 3, 10
Positron emission tomography (PET) imaging of P-glycoprotein (P-gp) in the blood-brain barrier can be important in neurological diseases where P-gp is affected, such as Alzheimer’s disease. Radiotracers used in the imaging studies are present at ve
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4d01fa620c3ddaa85244a25f4e0ec034
http://resolver.tudelft.nl/uuid:4dee5254-232e-4a69-9ae0-eb1757d461d3
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