Inhibition of Acetyl-CoA Carboxylase Causes Malformations in Rats and Rabbits: Comparison of Mammalian Findings and Alternative Assays.

Autor: Catlin NR; Drug Safety Research and Development, Pfizer Worldwide Research & Development, Groton, CT., Bowman CJ; Drug Safety Research and Development, Pfizer Worldwide Research & Development, Groton, CT., Campion SN; Drug Safety Research and Development, Pfizer Worldwide Research & Development, Groton, CT., Davenport SD; Drug Safety Research and Development, Pfizer Worldwide Research & Development, Groton, CT., Esler WP; Internal Medicine Research Unit, Pfizer Worldwide Research & Development, Cambridge, MA., Kumpf SW; Drug Safety Research and Development, Pfizer Worldwide Research & Development, Groton, CT., Lewis EM; Charles River Laboratories, Inc, Safety Assessment, Horsham, PA., Nowland WS; Drug Safety Research and Development, Pfizer Worldwide Research & Development, Groton, CT., Ross TT; Internal Medicine Research Unit, Pfizer Worldwide Research & Development, Cambridge, MA., Stedman DS; Drug Safety Research and Development, Pfizer Worldwide Research & Development, Groton, CT., Stethem C; Drug Safety Research and Development, Pfizer Worldwide Research & Development, Groton, CT., Cappon GD; Drug Safety Research and Development, Pfizer Worldwide Research & Development, Groton, CT.

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2021 Jan 28; Vol. 179 (2), pp. 183-194.