Zobrazeno 1 - 10 of 58 pro vyhledávání: '"Stebbeds W"'
1
Akademický článek
Strengthening cardiac therapy pipelines using human pluripotent stem cell-derived cardiomyocytes.
Autor: Raniga K; The Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK; Pathology, Non-Clinical Safety, GlaxoSmithKline R&D, Stevenage SG1 2NY, UK. Electronic address: kh.raniga@gmail.com., Nasir A; The Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK., Vo NTN; The Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK., Vaidyanathan R; FUJIFILM Cellular Dynamics, Inc., Madison, WI, USA., Dickerson S; FUJIFILM Cellular Dynamics, Inc., Madison, WI, USA., Hilcove S; FUJIFILM Cellular Dynamics, Inc., Madison, WI, USA., Mosqueira D; The Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK., Mirams GR; Centre for Mathematical Medicine & Biology, School of Mathematical Sciences, University of Nottingham, Nottingham NG7 2RD, UK., Clements P; Pathology, Non-Clinical Safety, GlaxoSmithKline R&D, Stevenage SG1 2NY, UK., Hicks R; BioPharmaceuticals R&D Cell Therapy Department, Research and Early Development, Cardiovascular, Renal, and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden; School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, London WC2R 2LS, UK., Pointon A; Safety Sciences, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB2 0AA, UK., Stebbeds W; LifeArc, Stevenage SG1 2FX, UK., Francis J; Mechanstic Biology and Profiling, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB2 0AA, UK., Denning C; The Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK. Electronic address: chris.denning@nottingham.ac.uk.
Publikováno v: Cell stem cell [Cell Stem Cell] 2024 Mar 07; Vol. 31 (3), pp. 292-311. Date of Electronic Publication: 2024 Feb 15.
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2
Akademický článek
Discovery and SAR Study of Boronic Acid-Based Selective PDE3B Inhibitors from a Novel DNA-Encoded Library.
Autor: Rowley AM; GSK, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Yao G; GSK, Encoded Library Technologies, NCE Molecular Discovery, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Andrews L; 23andMe Inc, Therapeutics, 349 Oyster Point Boulevard, South San Francisco, California 94080, United States., Bedermann A; GSK, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Biddulph R; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, Hertfordshire, U.K., Bingham R; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, Hertfordshire, U.K., Brady JJ; 23andMe Inc, Therapeutics, 349 Oyster Point Boulevard, South San Francisco, California 94080, United States., Buxton R; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, Hertfordshire, U.K., Cecconie T; GSK, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Cooper R; GSK, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Csakai A; GSK, Encoded Library Technologies, NCE Molecular Discovery, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Gao EN; GSK, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Grenier-Davies MC; GSK, Encoded Library Technologies, NCE Molecular Discovery, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Lawler M; GSK, Encoded Library Technologies, NCE Molecular Discovery, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Lian Y; GSK, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Macina J; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, Hertfordshire, U.K., Macphee C; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, Hertfordshire, U.K., Marcaurelle L; GSK, Encoded Library Technologies, NCE Molecular Discovery, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Martin J; GSK, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., McCormick P; GSK, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Pindoria R; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, Hertfordshire, U.K., Rauch M; GSK, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Rocque W; GSK, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Shen Y; GSK, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Shewchuk LM; GSK, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Squire M; GSK, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Stebbeds W; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, Hertfordshire, U.K., Tear W; GSK, Encoded Library Technologies, NCE Molecular Discovery, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Wang X; 23andMe Inc, Therapeutics, 349 Oyster Point Boulevard, South San Francisco, California 94080, United States., Ward P; GSK, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Xiao S; 23andMe Inc, Therapeutics, 349 Oyster Point Boulevard, South San Francisco, California 94080, United States.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Feb 08; Vol. 67 (3), pp. 2049-2065. Date of Electronic Publication: 2024 Jan 29.
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3
Akademický článek
Design of experiments for the automated development of a multicellular cardiac model for high-throughput screening.
Autor: Raniga K; The Biodiscovery Institute, University of Nottingham, Nottingham, UK, NG7 2RD; GlaxoSmithKline R&D, Stevenage, UK, SG1 2NY., Stebbeds W; LifeArc, Stevenage, UK, SG1 2FX., Shivalingam A; Synthace, The WestWorks, London, UK, W12 7FQ., Pemberton M; GlaxoSmithKline R&D, Stevenage, UK, SG1 2NY., Denning C; The Biodiscovery Institute, University of Nottingham, Nottingham, UK, NG7 2RD. Electronic address: chris.denning@nottingham.ac.uk.
Publikováno v: SLAS discovery : advancing life sciences R & D [SLAS Discov] 2023 Oct 28. Date of Electronic Publication: 2023 Oct 28.
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4
Akademický článek
CardioMotion: identification of functional and structural cardiotoxic liabilities in small molecules through brightfield kinetic imaging.
Autor: Stebbeds W; Screening Profiling and Mechanistic Biology, GSK, Stevenage, SG1 2NY, UK., Raniga K; Screening Profiling and Mechanistic Biology, GSK, Stevenage, SG1 2NY, UK.; The Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, UK., Standing D; Screening Profiling and Mechanistic Biology, GSK, Stevenage, SG1 2NY, UK., Wallace I; Screening Profiling and Mechanistic Biology, GSK, Stevenage, SG1 2NY, UK., Bayliss J; Screening Profiling and Mechanistic Biology, GSK, Stevenage, SG1 2NY, UK., Brown A; Screening Profiling and Mechanistic Biology, GSK, Stevenage, SG1 2NY, UK., Kasprowicz R; Screening Profiling and Mechanistic Biology, GSK, Stevenage, SG1 2NY, UK., Dalmas Wilk D; In vitro in vivo translation, GSK, Upper Providence, PA 19426, USA., Deakyne J; In vitro in vivo translation, GSK, Upper Providence, PA 19426, USA., Clements P; In vitro in vivo translation, GSK, Ware, SG12 0DJ, UK., Chaudhary KW; In vitro in vivo translation, GSK, Upper Providence, PA 19426, USA., Rossman EI; In vitro in vivo translation, GSK, Upper Providence, PA 19426, USA., Bahinski A; In vitro in vivo translation, GSK, Upper Providence, PA 19426, USA., Francis J; Screening Profiling and Mechanistic Biology, GSK, Stevenage, SG1 2NY, UK.
Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2023 Aug 29; Vol. 195 (1), pp. 61-70.
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5
Akademický článek
Prediction of inotropic effect based on calcium transients in human iPSC-derived cardiomyocytes and machine learning.
Autor: Yang H; Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, UK., Obrezanova O; Imaging and Data Analytics, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Pointon A; Functional and Mechanistic Safety, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Stebbeds W; Screening Profiling and Mechanistic Biology, Medicinal Science and Technology, GlaxoSmithKline, Stevenage, UK., Francis J; Mechanistic & Structural Biology, AstraZeneca, Cambridge, UK., Beattie KA; Target and Systems Safety, Non-Clinical Safety, In Vivo/In Vitro Translation, GlaxoSmithKline, Ware, UK., Clements P; Pathology UK, Non-Clinical Safety, In Vivo/In Vitro Translation, GlaxoSmithKline, Ware, UK., Harvey JS; Target and Systems Safety, Non-Clinical Safety, In Vivo/In Vitro Translation, GlaxoSmithKline, Ware, UK., Smith GF; Imaging and Data Analytics, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Bender A; Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, UK. Electronic address: ab454@cam.ac.uk.
Publikováno v: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2023 Jan 15; Vol. 459, pp. 116342. Date of Electronic Publication: 2022 Dec 09.
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6
Akademický článek
Deriving waveform parameters from calcium transients in human iPSC-derived cardiomyocytes to predict cardiac activity with machine learning.
Autor: Yang H; Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, UK., Stebbeds W; GlaxoSmithKline R&D, Stevenage, UK., Francis J; GlaxoSmithKline R&D, Stevenage, UK., Pointon A; Functional and Mechanistic Safety, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Obrezanova O; Imaging and Data Analytics, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Beattie KA; GlaxoSmithKline R&D, Ware, UK., Clements P; GlaxoSmithKline R&D, Ware, UK., Harvey JS; GlaxoSmithKline R&D, Ware, UK., Smith GF; Imaging and Data Analytics, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Bender A; Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, UK; Imaging and Data Analytics, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK. Electronic address: ab454@cam.ac.uk.
Publikováno v: Stem cell reports [Stem Cell Reports] 2022 Mar 08; Vol. 17 (3), pp. 556-568. Date of Electronic Publication: 2022 Feb 10.
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8
Akademický článek
The Current State of Realistic Heart Models for Disease Modelling and Cardiotoxicity.
Autor: Kistamás, Kornél1 (AUTHOR) kornel.kistamas@biotalentum.hu, Lamberto, Federica1,2 (AUTHOR) suchitra.polgari@biotalentum.hu, Vaiciuleviciute, Raminta3 (AUTHOR) raminta.vaiciuleviciute@imcentras.lt, Leal, Filipa4 (AUTHOR) pedro.costa@biofabics.com, Muenthaisong, Suchitra1 (AUTHOR) melinda.zana@biotalentum.hu, Marte, Luis5 (AUTHOR) luis.marte@eurecat.org, Subías-Beltrán, Paula5 (AUTHOR) paula.subias@eurecat.org, Alaburda, Aidas3,6 (AUTHOR) aidas.alaburda@gf.vu.lt, Arvanitis, Dina N.7 (AUTHOR) constandina.arvanitis@laas.fr, Zana, Melinda1 (AUTHOR), Costa, Pedro F.4 (AUTHOR), Bernotiene, Eiva3,8 (AUTHOR) eiva.bernotiene@imcentras.lt, Bergaud, Christian7 (AUTHOR) bergaud@laas.fr, Dinnyés, András1,2 (AUTHOR) andras.dinnyes@biotalentum.hu
Publikováno v: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 17, p9186. 34p.
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