Výsledky vyhledávání - "Steadman D. Harrison"

Toxicity of the Protein Kinase C Inhibitor Safingol Administered Alone and in Combination with Chemotherapeutic Agents

Autor: Robert L. Hall, Haig P. Bozigian, Lorrene Buckley Kedderis, Steadman D. Harrison, Robert L. Susick, James M. Kleeman, Thomas E. Palmer

Publikováno v: Fundamental and Applied Toxicology. 25:201-217

Toxicity of the Protein Kinase C Inhibitor Safingol Administered Alone and in Combination with Chemotherapeutic Agents. Kedderis, L. B., Bozigian, H. P., Kleeman, J. M., Hall, R. L., Palmer, T. E., Harrison, S. D., Jr., and Susick, R. L., Jr. (1995).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6abb6f4f0c8326d89732e121c674194f
https://doi.org/10.1006/faat.1995.1056

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Antitumor drug cross-resistance in vivo in a murine P388 leukemia resistant to ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazin-7-ylcarbamate 2-hydroxyethanesulfonate hydrate (NSC 370 147) 370 147

Autor: Griswold Dp, Carroll Temple, Steadman D. Harrison, William R. Waud

Publikováno v: Cancer Chemotherapy and Pharmacology. 29:190-194

Ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazin-7-ylcarbamate 2-hydroxyethanesulfonate hydrate (NSC 370 147) is a potent mitotic inhibitor, which has provided the basis for a candidate for clinical trial. As observed with clinically u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f7e41b96656a5c4bce13261d8c8d04
https://doi.org/10.1007/bf00686251

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Tumor models in drug development

Autor: Griswold Dp, Steadman D. Harrison

Publikováno v: Cancer and Metastasis Reviews. 10:255-261

In this short essay, we have taken the opportunity to review briefly the history of anticancer drug screening, consider the changes that have been made throughout that history, and reflect on the suitability of current screening practices and the mod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb89ba434e68d4fe69331ce81db567c3
https://doi.org/10.1007/bf00050796

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Schedule dependence, activity against natural metastases, and cross-resistance of pyrazine diazohydroxide (sodium salt, NSC 361456) in preclinical models in vivo

Autor: Griswold Dp, Steadman D. Harrison, William R. Waud, Jacqueline Plowman, Donald J. Dykes

Publikováno v: Cancer Chemotherapy and Pharmacology. 25:425-429

Pyrazine diazohydroxide (sodium salt, NSC 361456; PZDH) is a new antitumor drug with relatively broad activity in initial evaluations against murine leukemias, solid tumors, and two human tumor xenografts in vivo. The present studies were designed to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41228983da6cc55b8518acf0fdb49996
https://doi.org/10.1007/bf00686053

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A very early induction of major vault protein accompanied by increased drug resistance in U-937 cells

Autor: Jin Cao, Yi Hu, James J. Starling, Leonard H. Rome, Viswanath Devanarayan, Andrew G. Stephen, Lee R. Tanzer, Anne H. Dantzig, Robert E. Moore, Steadman D. Harrison, Christopher A. Slapak

Publikováno v: International journal of cancer. 97(2)

U-937 human leukemia cells were selected for resistance to doxorubicin in the presence or absence of a specific drug modulator that inhibits the activity of P-glycoprotein (Pgp), encoded by the multidrug-resistance gene (MDR1). Parental cells express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db6abba9a370bc7dec57e6823c43956a
https://pubmed.ncbi.nlm.nih.gov/11774257

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Cross-resistance of drug-resistant murine P388 leukemias to toxol in vivo

Autor: Steadman D. Harrison, Karen S. Gilbert, Griswold Dp, William R. Waud

Publikováno v: Cancer Chemotherapy and Pharmacology. 31:255-257

The antimicrotubule agent taxol (NSC 125973) has shown clinical antitumor activity against several classically refractory tumors. We developed a drug-resistance profile for taxol using ten drug-resistant P388 leukemias to identify potentially useful

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b157be0cb990bcf3c917a5959468c29
https://doi.org/10.1007/bf00685557

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Inhibition of intracellular Ca2+ signalling, cytotoxicity and antitumor activity of the herbicide oryzalin and its analogues

Autor: Steadman D. Harrison, Robert T. Abraham, Robert T. Dorr, Curtis L. Ashendel, Garth Powis, Katerina Dvorakova, Sydney E. Salmon, Loen H. Zalkow, Alfred Gallegos, John Worzalla

Publikováno v: Cancer chemotherapy and pharmacology. 41(1)

Purpose: Studies were conducted on oryzalin (3,5-dinitro-N,N-di(n-propyl)sulfanilamide), a widely used dinitroaniline sulfonamide herbicide, which was identified from plant extracts as an inhibitor of mitogen- and growth factor-mediated intracellular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65f8dddb03504d8bebbf919def67d3c
https://pubmed.ncbi.nlm.nih.gov/9443610

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Partial inhibition of multidrug resistance by safingol is independent of modulation of P-glycoprotein substrate activities and correlated with inhibition of protein kinase C

Autor: Clifford W. Sachs, Robert L. Fine, Steadman D. Harrison, Ahmad R. Safa

Publikováno v: The Journal of biological chemistry. 270(44)

Safingol is a lysosphingolipid protein kinase C (PKC) inhibitor that competitively interacts at the regulatory phorbol binding domain of PKC. We investigated the effects of safingol on antineoplastic drug sensitivity and PKC activity of MCF-7 tumor c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::693daf9c0388e4e92a88e8ff37201775
https://pubmed.ncbi.nlm.nih.gov/7592889

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