HSV-2 triggers upregulation of MALAT1 in CD4+ T cells and promotes HIV latency reversal.

Autor: Pierce CA; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, New York, USA., Loh LN; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, New York, USA., Steach HR; Department of Computational Biology., Cheshenko N; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, New York, USA., Preston-Hurlburt P; Department of Immunobiology, and., Zhang F; Department of Medicine, Yale School of Medicine, New Haven, Connecticut, USA., Stransky S; Department of Biochemistry and., Kravets L; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, New York, USA., Sidoli S; Department of Biochemistry and., Philbrick W; Department of Medicine, Yale School of Medicine, New Haven, Connecticut, USA., Nassar M; Department of Otorhinolaryngology-Head and Neck Surgery, Albert Einstein College of Medicine, New York, New York, USA., Krishnaswamy S; Department of Computational Biology.; Department of Genetics, Yale School of Medicine, New Haven, Connecticut, USA., Herold KC; Department of Immunobiology, and.; Department of Medicine, Yale School of Medicine, New Haven, Connecticut, USA., Herold BC; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, New York, USA.; Department of Pediatrics, Albert Einstein College of Medicine, New York, New York, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2023 Jun 01; Vol. 133 (11). Date of Electronic Publication: 2023 Jun 01.

Inflammasome activation in infected macrophages drives COVID-19 pathology.

Autor: Sefik E; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Qu R; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.; Computational Biology and Bioinformatics Program, Yale University, New Haven, CT, USA., Junqueira C; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Brazil., Kaffe E; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Mirza H; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA., Zhao J; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA., Brewer JR; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Han A; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Steach HR; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Israelow B; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Blackburn HN; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Department of Surgery, Yale University School of Medicine, New Haven, CT, USA., Velazquez SE; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Chen YG; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Halene S; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.; Section of Hematology, Yale Cancer Center and Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA., Iwasaki A; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA., Meffre E; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Nussenzweig M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.; Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA., Lieberman J; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Wilen CB; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA., Kluger Y; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.; Program of Applied Mathematics, Yale University, New Haven, CT, USA., Flavell RA; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. Richard.Flavell@yale.edu.; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA. Richard.Flavell@yale.edu.

Publikováno v: Nature [Nature] 2022 Jun; Vol. 606 (7914), pp. 585-593. Date of Electronic Publication: 2022 Apr 28.

Skin-resident innate lymphoid cells converge on a pathogenic effector state.

Autor: Bielecki P; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. piotr.stanislaw.bielecki@gmail.com.; Celsius Therapeutics, Cambridge, MA, USA. piotr.stanislaw.bielecki@gmail.com., Riesenfeld SJ; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. sriesenfeld@uchicago.edu.; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA. sriesenfeld@uchicago.edu.; Department of Medicine, University of Chicago, Chicago, IL, USA. sriesenfeld@uchicago.edu., Hütter JC; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Torlai Triglia E; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kowalczyk MS; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ricardo-Gonzalez RR; Department of Dermatology, University of California San Francisco, San Francisco, CA, USA.; Department of Medicine, Sandler Asthma Research Center, University of California San Francisco, San Francisco, CA, USA., Lian M; Würzburg Institute of Systems Immunology, Max Planck Research Group at the Julius-Maximilians-Universität Würzburg, Würzburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Amezcua Vesely MC; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Kroehling L; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Xu H; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Slyper M; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Muus C; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA., Ludwig LS; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Christian E; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Tao L; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kedaigle AJ; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Steach HR; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., York AG; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Skadow MH; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Yaghoubi P; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Dionne D; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Jarret A; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., McGee HM; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; NOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Sciences, La Jolla, CA, USA., Porter CBM; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Licona-Limón P; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Departamento de Biología Celular y del Desarrollo, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México City, Mexico., Bailis W; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Jackson R; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Gagliani N; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Immunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institute and University Hospital, Stockholm, Sweden., Gasteiger G; Würzburg Institute of Systems Immunology, Max Planck Research Group at the Julius-Maximilians-Universität Würzburg, Würzburg, Germany., Locksley RM; Department of Medicine, Sandler Asthma Research Center, University of California San Francisco, San Francisco, CA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Regev A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. aregev@broadinstitute.org.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. aregev@broadinstitute.org.; Koch Institute of Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. aregev@broadinstitute.org.; Genentech, South San Francisco, CA, USA. aregev@broadinstitute.org., Flavell RA; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. richard.flavell@yale.edu.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. richard.flavell@yale.edu.

Publikováno v: Nature [Nature] 2021 Apr; Vol. 592 (7852), pp. 128-132. Date of Electronic Publication: 2021 Feb 03.

Kidney tissue hypoxia dictates T cell-mediated injury in murine lupus nephritis.

Autor: Chen PM; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA., Wilson PC; Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA., Shyer JA; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA., Veselits M; Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, Departments of Medicine and Pathology, University of Chicago, Chicago, IL 60637, USA., Steach HR; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA., Cui C; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA., Moeckel G; Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA., Clark MR; Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, Departments of Medicine and Pathology, University of Chicago, Chicago, IL 60637, USA., Craft J; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. joseph.craft@yale.edu.; Department of Internal Medicine (Rheumatology, Allergy and Immunology), Yale University School of Medicine, New Haven, CT 06520, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2020 Apr 08; Vol. 12 (538).

Author Correction: Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity.

Autor: Solis AG; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Bielecki P; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Steach HR; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Sharma L; Department of Internal Medicine, Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA., Harman CCD; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA., Yun S; Department of Internal Medicine (Cardiology), Yale Cardiovascular Research Center, Yale University, New Haven, CT, USA.; Department of Cell Biology, Yale Cardiovascular Research Center, Yale University, New Haven, CT, USA.; Department of Biomedical Engineering, Yale Cardiovascular Research Center, Yale University, Yale University, New Haven, CT, USA., de Zoete MR; Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, The Netherlands., Warnock JN; School of Chemical, Materials and Biomedical Engineering, University of Georgia, Athens, GA, USA., To SDF; Department of Agricultural and Biological Engineering, Mississippi State University, Mississippi State, MS, USA., York AG; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Mack M; Department of Internal Medicine II-Nephrology, University Hospital Regensburg, Regensburg, Germany., Schwartz MA; Department of Internal Medicine (Cardiology), Yale Cardiovascular Research Center, Yale University, New Haven, CT, USA.; Department of Cell Biology, Yale Cardiovascular Research Center, Yale University, New Haven, CT, USA.; Department of Biomedical Engineering, Yale Cardiovascular Research Center, Yale University, Yale University, New Haven, CT, USA., Cruz CSD; Department of Internal Medicine, Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA., Palm NW; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Jackson R; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. ruaidhri.jackson@yale.edu., Flavell RA; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. richard.flavell@yale.edu.; Howard Hughes Medical Institute, Yale University, New Haven, CT, USA. richard.flavell@yale.edu.

Publikováno v: Nature [Nature] 2019 Nov; Vol. 575 (7784), pp. E7.