IL-4 Licenses B Cell Activation Through Cholesterol Synthesis.

Autor: Steach HR, York AG, Skadow MH, Chen S, Zhao J, Williams KJ, Zhou Q, Hsieh WY, Brewer JR, Qu R, Shyer JA, Harman C, Sefik E, Mowell WK, Bailis W, Cui C, Kluger Y, Bensinger SJ, Craft J, Flavell RA

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 May 15. Date of Electronic Publication: 2024 May 15.

The Manifold Scattering Transform for High-Dimensional Point Cloud Data.

Autor: Chew J; UCLA Department of Mathematics, Los Angeles, CA, USA., Steach HR; Yale University, Department of Genetics, New Haven, CT, USA., Viswanath S; UC Irvine Department of Computer Science, Irvine, CA, USA., Wu HT; Duke University, Department of Mathematics, Durham, NC, USA.; Duke University, Department of Statistical Science, Durham, NC, USA., Hirn M; Michigan State University, Department of Mathematics, East Lansing, USA.; Michigan State University, Department of CMSE, East Lansing, USA., Needell D; UCLA Department of Mathematics, Los Angeles, CA, USA., Krishnaswamy S; Yale University, Department of Genetics, New Haven, CT, USA.; Yale University, Department of Computer Science, New Haven, CT, USA.; Yale University, Applied Math Program, New Haven, CT, USA., Perlmutter M; UCLA Department of Mathematics, Los Angeles, CA, USA.

Publikováno v: Proceedings of machine learning research [Proc Mach Learn Res] 2022 Jul; Vol. 196, pp. 67-78.

Skin-resident innate lymphoid cells converge on a pathogenic effector state.

Autor: Bielecki P; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. piotr.stanislaw.bielecki@gmail.com.; Celsius Therapeutics, Cambridge, MA, USA. piotr.stanislaw.bielecki@gmail.com., Riesenfeld SJ; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. sriesenfeld@uchicago.edu.; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA. sriesenfeld@uchicago.edu.; Department of Medicine, University of Chicago, Chicago, IL, USA. sriesenfeld@uchicago.edu., Hütter JC; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Torlai Triglia E; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kowalczyk MS; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ricardo-Gonzalez RR; Department of Dermatology, University of California San Francisco, San Francisco, CA, USA.; Department of Medicine, Sandler Asthma Research Center, University of California San Francisco, San Francisco, CA, USA., Lian M; Würzburg Institute of Systems Immunology, Max Planck Research Group at the Julius-Maximilians-Universität Würzburg, Würzburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Amezcua Vesely MC; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Kroehling L; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Xu H; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Slyper M; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Muus C; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA., Ludwig LS; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Christian E; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Tao L; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kedaigle AJ; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Steach HR; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., York AG; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Skadow MH; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Yaghoubi P; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Dionne D; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Jarret A; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., McGee HM; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; NOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Sciences, La Jolla, CA, USA., Porter CBM; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Licona-Limón P; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Departamento de Biología Celular y del Desarrollo, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México City, Mexico., Bailis W; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Jackson R; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Gagliani N; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Immunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institute and University Hospital, Stockholm, Sweden., Gasteiger G; Würzburg Institute of Systems Immunology, Max Planck Research Group at the Julius-Maximilians-Universität Würzburg, Würzburg, Germany., Locksley RM; Department of Medicine, Sandler Asthma Research Center, University of California San Francisco, San Francisco, CA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Regev A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. aregev@broadinstitute.org.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. aregev@broadinstitute.org.; Koch Institute of Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. aregev@broadinstitute.org.; Genentech, South San Francisco, CA, USA. aregev@broadinstitute.org., Flavell RA; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. richard.flavell@yale.edu.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. richard.flavell@yale.edu.

Publikováno v: Nature [Nature] 2021 Apr; Vol. 592 (7852), pp. 128-132. Date of Electronic Publication: 2021 Feb 03.

An in vivo screen of noncoding loci reveals that Daedalus is a gatekeeper of an Ikaros-dependent checkpoint during haematopoiesis.

Autor: Harman CCD; Department of Genetics, Yale School of Medicine, New Haven, CT 06520.; Howard Hughes Medical Institute, New Haven, CT 06520., Bailis W; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104., Zhao J; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520.; Department of Pathology, Yale School of Medicine, New Haven, CT 06510.; Program of Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520., Hill L; Research Institute of Molecular Pathology, Vienna Biocenter, 1030 Vienna, Austria., Qu R; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520.; Department of Pathology, Yale School of Medicine, New Haven, CT 06510.; Program of Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520., Jackson RP; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520., Shyer JA; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520., Steach HR; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520., Kluger Y; Department of Pathology, Yale School of Medicine, New Haven, CT 06510.; Program of Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520.; Applied Mathematics Program, Yale University, New Haven, CT 06511., Goff LA; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205., Rinn JL; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138.; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02115.; Department of Biochemistry, University of Colorado, BioFrontiers Institute, Boulder, CO 80301., Williams A; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032.; Department of Genetics and Genomic Sciences, University of Connecticut Health Center, Farmington, CT 06030., Henao-Mejia J; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104., Flavell RA; Howard Hughes Medical Institute, New Haven, CT 06520; richard.flavell@yale.edu.; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Jan 19; Vol. 118 (3).

Cross-Reactivity with Self-Antigen Tunes the Functional Potential of Naive B Cells Specific for Foreign Antigens.

Autor: Steach HR; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109., DeBuysscher BL; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109., Schwartz A; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109., Boonyaratanakornkit J; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109., Baker ML; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109., Tooley MR; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109., Pease NA; Molecular and Cellular Biology Program, University of Washington and Fred Hutchinson Cancer Research Center, Seattle, WA 98195., Taylor JJ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109; jtaylor3@fredhutch.org.; Department of Global Health, University of Washington, Seattle, WA 98195; and.; Department of Immunology, University of Washington, Seattle, WA 98109.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2020 Feb 01; Vol. 204 (3), pp. 498-509. Date of Electronic Publication: 2019 Dec 27.