The Marine Neurotoxin Brevetoxin (PbTx-2) Inhibits Karenia brevis and Mammalian Thioredoxin Reductases by Targeting Different Residues.

Autor: Colon R; Department of Chemistry and Biochemistry, Florida International University, 11200 SW 8th Street, Miami, Florida 33199, United States., Wheater M; Department of Biochemistry, University of Vermont, 89 Beaumont Avenue, Given Building Room 413B, Burlington, Vermont 05405, United States., Joyce EJ; Department of Biochemistry, University of Vermont, 89 Beaumont Avenue, Given Building Room 413B, Burlington, Vermont 05405, United States., Ste Marie EJ; Department of Biochemistry, University of Vermont, 89 Beaumont Avenue, Given Building Room 413B, Burlington, Vermont 05405, United States., Hondal RJ; Department of Biochemistry, University of Vermont, 89 Beaumont Avenue, Given Building Room 413B, Burlington, Vermont 05405, United States., Rein KS; Department of Chemistry and Biochemistry, Florida International University, 11200 SW 8th Street, Miami, Florida 33199, United States.

Publikováno v: Journal of natural products [J Nat Prod] 2021 Nov 26; Vol. 84 (11), pp. 2961-2970. Date of Electronic Publication: 2021 Nov 09.

Can Selenoenzymes Resist Electrophilic Modification? Evidence from Thioredoxin Reductase and a Mutant Containing α-Methylselenocysteine.

Autor: Ste Marie EJ; Department of Biochemistry, University of Vermont, 89 Beaumont Avenue, Burlington, Vermont 05405, United States.; Department of Chemistry, Discovery Hall, University of Vermont, 82 University Place, Burlington, Vermont 05405, United States., Wehrle RJ; School of Mathematics and Natural Sciences, Chemistry and Biochemistry, University of Southern Mississippi, 118 College Drive, Hattiesburg, Mississippi 39406, United States., Haupt DJ; Department of Chemistry, Discovery Hall, University of Vermont, 82 University Place, Burlington, Vermont 05405, United States., Wood NB; Department of Molecular Physiology & Biophysics, University of Vermont, 89 Beaumont Avenue, Burlington, Vermont 05405, United States., van der Vliet A; Department of Pathology and Laboratory Medicine, University of Vermont, 149 Beaumont Avenue, Burlington, Vermont 05405, United States., Previs MJ; Department of Molecular Physiology & Biophysics, University of Vermont, 89 Beaumont Avenue, Burlington, Vermont 05405, United States., Masterson DS; School of Mathematics and Natural Sciences, Chemistry and Biochemistry, University of Southern Mississippi, 118 College Drive, Hattiesburg, Mississippi 39406, United States., Hondal RJ; Department of Biochemistry, University of Vermont, 89 Beaumont Avenue, Burlington, Vermont 05405, United States.; Department of Chemistry, Discovery Hall, University of Vermont, 82 University Place, Burlington, Vermont 05405, United States.

Publikováno v: Biochemistry [Biochemistry] 2020 Sep 15; Vol. 59 (36), pp. 3300-3315. Date of Electronic Publication: 2020 Aug 30.

Facile removal of 4-methoxybenzyl protecting group from selenocysteine.

Autor: Jenny KA; Department of Chemistry, Discovery Hall, University of Vermont, Burlington, Vermont., Ste Marie EJ; Department of Chemistry, Discovery Hall, University of Vermont, Burlington, Vermont.; Department of Biochemistry, University of Vermont, Burlington, Vermont., Mose G; Department of Biochemistry, University of Vermont, Burlington, Vermont., Ruggles EL; Department of Chemistry, Discovery Hall, University of Vermont, Burlington, Vermont., Hondal RJ; Department of Chemistry, Discovery Hall, University of Vermont, Burlington, Vermont.; Department of Biochemistry, University of Vermont, Burlington, Vermont.

Publikováno v: Journal of peptide science : an official publication of the European Peptide Society [J Pept Sci] 2019 Oct; Vol. 25 (10), pp. e3209. Date of Electronic Publication: 2019 Aug 13.

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke.

Autor: Alim I; Sperling Center for Hemorrhagic Stroke Recovery, Burke Neurological Institute at Weill Cornell Medicine, White Plains, NY 10605, USA; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10065, USA., Caulfield JT; Sperling Center for Hemorrhagic Stroke Recovery, Burke Neurological Institute at Weill Cornell Medicine, White Plains, NY 10605, USA; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10065, USA., Chen Y; Sperling Center for Hemorrhagic Stroke Recovery, Burke Neurological Institute at Weill Cornell Medicine, White Plains, NY 10605, USA; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10065, USA., Swarup V; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA; Institute for Memory Impairments and Neurological Disorders (UCI MIND), Irvine, CA 92697, USA., Geschwind DH; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA., Ivanova E; Sperling Center for Hemorrhagic Stroke Recovery, Burke Neurological Institute at Weill Cornell Medicine, White Plains, NY 10605, USA; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10065, USA., Seravalli J; Redox Biology Center and Department of Biochemistry, University of Nebraska, Lincoln, NE 68588, USA., Ai Y; Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA., Sansing LH; Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA., Ste Marie EJ; Department of Biochemistry, University of Vermont, Burlington, VT 05405, USA., Hondal RJ; Department of Biochemistry, University of Vermont, Burlington, VT 05405, USA., Mukherjee S; Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA., Cave JW; Sperling Center for Hemorrhagic Stroke Recovery, Burke Neurological Institute at Weill Cornell Medicine, White Plains, NY 10605, USA; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10065, USA., Sagdullaev BT; Sperling Center for Hemorrhagic Stroke Recovery, Burke Neurological Institute at Weill Cornell Medicine, White Plains, NY 10605, USA; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10065, USA., Karuppagounder SS; Sperling Center for Hemorrhagic Stroke Recovery, Burke Neurological Institute at Weill Cornell Medicine, White Plains, NY 10605, USA; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10065, USA., Ratan RR; Sperling Center for Hemorrhagic Stroke Recovery, Burke Neurological Institute at Weill Cornell Medicine, White Plains, NY 10605, USA; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address: rrr2001@med.cornell.edu.

Publikováno v: Cell [Cell] 2019 May 16; Vol. 177 (5), pp. 1262-1279.e25. Date of Electronic Publication: 2019 May 02.

Removal of the 5-nitro-2-pyridine-sulfenyl protecting group from selenocysteine and cysteine by ascorbolysis.

Autor: Ste Marie EJ; Department of Chemistry, Cook Physical Sciences Bldg, University of Vermont, 82 University Place, Burlington, VT, 05405, USA., Ruggles EL; Department of Chemistry, Cook Physical Sciences Bldg, University of Vermont, 82 University Place, Burlington, VT, 05405, USA., Hondal RJ; Department of Biochemistry, University of Vermont, 89 Beaumont Ave., Given Laboratory, Room B413, Burlington, VT, 05405, USA.

Publikováno v: Journal of peptide science : an official publication of the European Peptide Society [J Pept Sci] 2016 Sep; Vol. 22 (9), pp. 571-6. Date of Electronic Publication: 2016 Aug 02.