Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Stavroula Sofou"'
Autor:
Michail E. Kavousanakis, Omkar Bhatavdekar, Remco Bastiaannet, Yannis Kevrekidis, Stavroula Sofou
Publikováno v:
Physical Review Research, Vol 6, Iss 3, p 033137 (2024)
Beyond biological cell heterogeneity, evidenced by different resistances to therapeutics, “delivery heterogeneity” crucially limits treatment efficacy for advanced solid tumors: variations in therapeutic drug delivery to different tumor areas (pe
Externí odkaz:
https://doaj.org/article/d15fbe5e3ffe40a9804dcbff0c4b3cf2
Autor:
Dominick Salerno, Alaina Howe, Omkar Bhatavdekar, Anders Josefsson, Jesus Pacheco‐Torres, Zaver M. Bhujwalla, Kathleen L. Gabrielson, Stavroula Sofou
Publikováno v:
Bioengineering & Translational Medicine, Vol 7, Iss 2, Pp n/a-n/a (2022)
Abstract Partial and/or heterogeneous irradiation of established (i.e., large, vascularized) tumors by α‐particles that exhibit only a 4–5 cell‐diameter range in tissue, limits the therapeutic effect, since regions not being hit by the high en
Externí odkaz:
https://doaj.org/article/f3d7177fd9af4ec7b084eb2668ffc9e0
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2184 (2022)
To best control tumor growth and/or metastasis in triple negative breast cancer (TNBC), it may be useful to understand the effect(s) of chemotherapy delivery (i.e., the rate and pattern of exposure to the drug) on cell sub-populations that have exper
Externí odkaz:
https://doaj.org/article/8a0b7e7c716246758eb0decdf56266dc
Autor:
Dominick Salerno, Stavroula Sofou
Publikováno v:
Pharmaceuticals, Vol 14, Iss 10, p 1035 (2021)
Combinations of platinum-based compounds with doxorubicin in free and/or in liposomal form for improved safety are currently being evaluated in the neoadjuvant setting on patients with advanced triple-negative breast cancer (TNBC). However, TNBC may
Externí odkaz:
https://doaj.org/article/9cfc1d8e973743bfb8955031c3eff484
Autor:
Stavroula Sofou
Publikováno v:
International Journal of Nanomedicine, Vol 2008, Iss Issue 2, Pp 181-199 (2008)
Stavroula SofouLaboratory for Drug Delivery Systems, Othmer-Jacobs Department of Chemical and Biological Engineering, Polytechnic University, Brooklyn, NY, USAAbstract: This review describes strategies for the delivery of therapeutic radionuclides to
Externí odkaz:
https://doaj.org/article/b65b86097b80470c99656d6d29a8cc07
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 49:3989-3999
The spatial distribution of radiopharmaceuticals within multicellular clusters is known to have a significant effect on their biological response. Most therapeutic radiopharmaceuticals distribute nonuniformly in tissues which makes predicting respons
Autor:
Stavroula Sofou, Alfred Morgenstern, Frank Bruchertseifer, Martin G. Pomper, Sangeeta Ray Banerjee, Michelle Sempkowski, Amey Bandekar, Charles Zhu
This study aims to evaluate the effect on killing efficacy of the intracellular trafficking patterns of α-particle emitters by using different radionuclide carriers in the setting of targeted antivascular α-radiotherapy. Nanocarriers (lipid vesicle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f38227956279c2ebc6e780234dec488
https://doi.org/10.1158/1535-7163.c.6537633
https://doi.org/10.1158/1535-7163.c.6537633
Autor:
Stavroula Sofou, Alfred Morgenstern, Frank Bruchertseifer, Martin G. Pomper, Sangeeta Ray Banerjee, Michelle Sempkowski, Amey Bandekar, Charles Zhu
Viability (evaluated after one doubling time) of PSMA-positive HUVEC as a function of delivered radioactivity per cell.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ef343fa013d26495acd921df7ed0f5
https://doi.org/10.1158/1535-7163.22504143
https://doi.org/10.1158/1535-7163.22504143
Publikováno v:
IFAC-PapersOnLine. 55:104-108
Autor:
Stavroula Sofou, Alaina Howe, Anders Josefsson, Zaver M. Bhujwalla, Jesús Pacheco-Torres, Kathleen L. Gabrielson, Dominick Salerno, George Sgouros, Omkar Bhatavdekar
Publikováno v:
J Nucl Med
Alpha-particle radiotherapy has already been shown to be impervious to most resistance mechanisms. However, in established (i.e. large, vascularized) soft-tissue lesions, the diffusion-limited penetration depths of radiolabeled antibodies and/or nano