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Nucleosides rescue replication-mediated genome instability of human pluripotent stem cells

Autor: Halliwell, J.A., Frith, T.J.R., Laing, O., Price, C.J., Bower, O.J., Stavish, D., Gokhale, P.J., Hewitt, Z., El-Khamisy, S.F., Barbaric, I., Andrews, P.W.

Publikováno v: bioRxiv

Human pluripotent stem cells (PSC) often acquire genetic changes on prolonged culture, which pose concerns for their use in research and regenerative medicine (Amps et al., 2011, Seth et al., 2011). The acquisition of these changes during culture nec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::afae0ecef999c05b9426a6cc4f2deab5
https://eprints.whiterose.ac.uk/161530/1/1-s2.0-S2213671120301442-main.pdf

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Time-Lapse Analysis of Human Embryonic Stem Cells Reveals Multiple Bottlenecks Restricting Colony Formation and Their Relief upon Culture Adaptation

Autor: Barbaric, I., Biga, V., Gokhale, P.J., Jones, M., Stavish, D., Glen, A., Coca, D., Andrews, P.W.

Publikováno v: Stem Cell Reports
Barbaric, I, Biga, V, Gokhale, P J, Jones, M, Stavish, D, Glen, A, Coca, D & Andrews, P W 2014, ' Time-lapse analysis of human embryonic stem cells reveals multiple bottlenecks restricting colony formation and their relief upon culture adaptation ', Stem Cell Reports, vol. 3, no. 1, pp. 142-155 . https://doi.org/10.1016/j.stemcr.2014.05.006
Stem Cell Reports, Vol 3, Iss 1, Pp 142-155 (2014)

Summary Using time-lapse imaging, we have identified a series of bottlenecks that restrict growth of early-passage human embryonic stem cells (hESCs) and that are relieved by karyotypically abnormal variants that are selected by prolonged culture. On

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::aaa356a3fa0f885367a5e6ab23f64e5e