Zobrazeno 1 - 10
of 367
pro vyhledávání: '"Stary ‐ Weinzinger, A"'
Autor:
Anna Stary-Weinzinger
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
In cardiac cells, the expression of the cardiac voltage-gated Na+ channel (NaV1.5) is reciprocally regulated with the inward rectifying K+ channel (KIR2.1). These channels can form macromolecular complexes that pre-assemble early during forward traff
Externí odkaz:
https://doaj.org/article/f33fea30be7d421aac767ad8d8a837c1
Autor:
Grigory Maksaev, Michael Bründl-Jirout, Anna Stary-Weinzinger, Eva-Maria Zangerl-Plessl, Sun-Joo Lee, Colin G. Nichols
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Inwardly rectifying potassium (Kir) channels open at the ‘helix bundle crossing’ (HBC), formed by the M2 helices at the cytoplasmic end of the transmembrane pore. Introduced negative charges at the HBC (G178D) in Kir2.2 channels forces o
Externí odkaz:
https://doaj.org/article/13b6793a2f8e4b3ab216e0190876a3e2
β subunits of GABAA receptors form proton-gated chloride channels: Insights into the molecular basis
Autor:
Aleksandra Garifulina, Theres Friesacher, Marco Stadler, Eva-Maria Zangerl-Plessl, Margot Ernst, Anna Stary-Weinzinger, Anita Willam, Steffen Hering
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
Beta subunits of GABAA receptors are unexpectedly shown to form homomeric proton gated ion channels attributable to a single histidine residue.
Externí odkaz:
https://doaj.org/article/9f38e7c2b0fb44b284dedd98ef6ee721
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
The opening and closing of voltage-dependent potassium channels is dependent on a tight coupling between movement of the voltage sensing S4 segments and the activation gate. A specific interaction between intracellular amino- and carboxyl-termini is
Externí odkaz:
https://doaj.org/article/6a5e3708eaaa467c9065cdbdc1b88649
Autor:
Theres Friesacher, Haritha P. Reddy, Harald Bernsteiner, J. Carlo Combista, Boris Shalomov, Amal K. Bera, Eva-Maria Zangerl-Plessl, Nathan Dascal, Anna Stary-Weinzinger
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Gly selectivity filter (TIGYGYR) mutant of the GIRK2 channel causes rare but severe neurological disorder called the Keppen-Lubinsky syndrome. Here, the authors explore the molecular mechanism of action of this glycine to serine mutant causing diseas
Externí odkaz:
https://doaj.org/article/06836862f38b478c94f96d2c99760011
Autor:
Benjamin Hackl, Peter Lukacs, Janine Ebner, Krisztina Pesti, Nicholas Haechl, Mátyás C Földi, Elena Lilliu, Klaus Schicker, Helmut Kubista, Anna Stary-Weinzinger, Karlheinz Hilber, Arpad Mike, Hannes Todt, Xaver Koenig
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background and purpose: Ivabradine is clinically administered to lower the heart rate, proposedly by inhibiting hyperpolarization-activated cyclic nucleotide-gated cation channels in the sinoatrial node. Recent evidence suggests that voltage-gated so
Externí odkaz:
https://doaj.org/article/e295a630726340d7b8226a0bb7cfdbfb
Autor:
Marien J. C. Houtman, Theres Friesacher, Xingyu Chen, Eva-Maria Zangerl-Plessl, Marcel A. G. van der Heyden, Anna Stary-Weinzinger
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Introduction: DEND syndrome is a rare channelopathy characterized by a combination of developmental delay, epilepsy and severe neonatal diabetes. Gain of function mutations in the KCNJ11 gene, encoding the KIR6.2 subunit of the IKATP potassium channe
Externí odkaz:
https://doaj.org/article/f720fead0f634b2e88a84576c7772e8d
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
ATP-sensitive potassium (KATP) channels consist of an inwardly rectifying K+ channel (Kir6.2) pore, to which four ATP-sensitive sulfonylurea receptor (SUR) domains are attached, thereby coupling K+ permeation directly to the metabolic state of the ce
Externí odkaz:
https://doaj.org/article/9d84dbe090234142947e26e469fe4838
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.