RORγt inhibition ameliorates IL-23 driven experimental psoriatic arthritis by predominantly modulating γδ-T cells.

Autor: Mortier C; Department of Rheumatology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.; Unit for Molecular Immunology and Inflammation, VIB-UGent Center for Inflammation Research, Ghent, Belgium., Gracey E; Department of Rheumatology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.; Unit for Molecular Immunology and Inflammation, VIB-UGent Center for Inflammation Research, Ghent, Belgium., Coudenys J; Department of Rheumatology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.; Unit for Molecular Immunology and Inflammation, VIB-UGent Center for Inflammation Research, Ghent, Belgium., Manuello T; Department of Rheumatology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.; Unit for Molecular Immunology and Inflammation, VIB-UGent Center for Inflammation Research, Ghent, Belgium., Decruy T; Department of Rheumatology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.; Unit for Molecular Immunology and Inflammation, VIB-UGent Center for Inflammation Research, Ghent, Belgium., Maelegheer M; Department of Rheumatology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.; Unit for Molecular Immunology and Inflammation, VIB-UGent Center for Inflammation Research, Ghent, Belgium., Stappers F; Department of Rheumatology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.; Unit for Molecular Immunology and Inflammation, VIB-UGent Center for Inflammation Research, Ghent, Belgium., Gilis E; Department of Rheumatology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.; Unit for Molecular Immunology and Inflammation, VIB-UGent Center for Inflammation Research, Ghent, Belgium., Gaublomme D; Department of Rheumatology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.; Unit for Molecular Immunology and Inflammation, VIB-UGent Center for Inflammation Research, Ghent, Belgium., Van Hoorebeke L; UGCT, Department of Physics and Astronomy, Ghent University, Ghent, Belgium., Van Welden S; IBD Research Unit, Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.; Intestinal Barrier Signaling in Disease and Therapy, VIB-UGent Center for Inflammation Research, Ghent, Belgium., Ambler C; Drug Product Design, Pfizer Inc, San Diego, CA, USA., Hegen M; Inflammation and Immunology Research Unit, Pfizer Inc, Cambridge, MA, USA., Symanowicz P; Inflammation and Immunology Research Unit, Pfizer Inc, Cambridge, MA, USA., Steyn S; Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc, Cambridge, MA, USA., Berstein G; Inflammation and Immunology Research Unit, Pfizer Inc, Cambridge, MA, USA., Elewaut D; Department of Rheumatology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.; Unit for Molecular Immunology and Inflammation, VIB-UGent Center for Inflammation Research, Ghent, Belgium., Venken K; Department of Rheumatology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.; Unit for Molecular Immunology and Inflammation, VIB-UGent Center for Inflammation Research, Ghent, Belgium.

Publikováno v: Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2023 Sep 01; Vol. 62 (9), pp. 3169-3178.

Neutralising anti-drug antibodies in Fabry disease can inhibit endothelial enzyme uptake and activity.

Autor: Stappers F; Internal Medicine D, Department of Nephrology, Hypertension and Rheumatology, University Hospital Muenster, Muenster, Germany., Scharnetzki D; Internal Medicine D, Department of Nephrology, Hypertension and Rheumatology, University Hospital Muenster, Muenster, Germany., Schmitz B; Institute of Sports Medicine, Molecular Genetics of Cardiovascular Disease, University Hospital Muenster, Muenster, Germany., Manikowski D; Institute of Physiological Chemistry and Pathobiochemistry and Cells-in-Motion Cluster of Excellence (EXC1003-CiM), University of Muenster, Muenster, Germany., Brand SM; Institute of Sports Medicine, Molecular Genetics of Cardiovascular Disease, University Hospital Muenster, Muenster, Germany., Grobe K; Institute of Physiological Chemistry and Pathobiochemistry and Cells-in-Motion Cluster of Excellence (EXC1003-CiM), University of Muenster, Muenster, Germany., Lenders M; Internal Medicine D, Department of Nephrology, Hypertension and Rheumatology, University Hospital Muenster, Muenster, Germany., Brand E; Internal Medicine D, Department of Nephrology, Hypertension and Rheumatology, University Hospital Muenster, Muenster, Germany.

Publikováno v: Journal of inherited metabolic disease [J Inherit Metab Dis] 2020 Mar; Vol. 43 (2), pp. 334-347. Date of Electronic Publication: 2019 Nov 14.

Detailed epitope mapping of neutralizing anti-drug antibodies against recombinant α-galactosidase A in patients with Fabry disease.

Autor: Scharnetzki D; Internal Medicine D, Department of Nephrology, Hypertension and Rheumatology, Interdisciplinary Fabry Center Münster (IFAZ), University Hospital Muenster, 48149 Muenster, Germany., Stappers F; Internal Medicine D, Department of Nephrology, Hypertension and Rheumatology, Interdisciplinary Fabry Center Münster (IFAZ), University Hospital Muenster, 48149 Muenster, Germany., Lenders M; Internal Medicine D, Department of Nephrology, Hypertension and Rheumatology, Interdisciplinary Fabry Center Münster (IFAZ), University Hospital Muenster, 48149 Muenster, Germany. Electronic address: Malte.Lenders@ukmuenster.de., Brand E; Internal Medicine D, Department of Nephrology, Hypertension and Rheumatology, Interdisciplinary Fabry Center Münster (IFAZ), University Hospital Muenster, 48149 Muenster, Germany.

Publikováno v: Molecular genetics and metabolism [Mol Genet Metab] 2020 Sep - Oct; Vol. 131 (1-2), pp. 229-234. Date of Electronic Publication: 2020 Aug 28.

Establishing Treatment Effectiveness in Fabry Disease: Observation-Based Recommendations for Improvement.

Autor: Veldman, Bram C. F.¹ (AUTHOR) b.c.f.veldman@amsterdamumc.nl, Schoenmakers, Daphne H.^2,3 (AUTHOR), van Dussen, Laura¹ (AUTHOR), Datema, Mareen R.¹ (AUTHOR), Langeveld, Mirjam¹ (AUTHOR) m.langeveld@amsterdamumc.nl

Publikováno v: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 17, p9752. 20p.

Mutation-specific Fabry disease patient-derived cell model to evaluate the amenability to chaperone therapy.

Autor: Lenders M; Internal Medicine D, Department of Nephrology, Hypertension and Rheumatology, University Hospital Muenster, Muenster, Germany malte.lenders@ukmuenster.de., Stappers F; Internal Medicine D, Department of Nephrology, Hypertension and Rheumatology, University Hospital Muenster, Muenster, Germany., Niemietz C; Medizinische Klinik B für Gastroenterologie und Hepatologie, University Hospital Muenster, Muenster, Germany., Schmitz B; Institute of Sports Medicine, Molecular Genetics of Cardiovascular Disease, University Hospital Muenster, Muenster, Germany., Boutin M; Department of Pediatrics, Division of Medical Genetics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, Canada., Ballmaier PJ; Medizinische Klinik B für Gastroenterologie und Hepatologie, University Hospital Muenster, Muenster, Germany., Zibert A; Medizinische Klinik B für Gastroenterologie und Hepatologie, University Hospital Muenster, Muenster, Germany., Schmidt H; Medizinische Klinik B für Gastroenterologie und Hepatologie, University Hospital Muenster, Muenster, Germany., Brand SM; Institute of Sports Medicine, Molecular Genetics of Cardiovascular Disease, University Hospital Muenster, Muenster, Germany., Auray-Blais C; Department of Pediatrics, Division of Medical Genetics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, Canada., Brand E; Internal Medicine D, Department of Nephrology, Hypertension and Rheumatology, University Hospital Muenster, Muenster, Germany.

Publikováno v: Journal of medical genetics [J Med Genet] 2019 Aug; Vol. 56 (8), pp. 548-556. Date of Electronic Publication: 2019 Apr 22.