Zobrazeno 1 - 10
of 510
pro vyhledávání: '"Stapled peptides"'
Autor:
Wei Cong, Huaxing Shen, Xiufei Liao, Mengjun Zheng, Xianglong Kong, Zhe Wang, Si Chen, Yulei Li, Honggang Hu, Xiang Li
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 9, Pp 3770-3781 (2023)
Stapled peptides with significantly enhanced pharmacological profiles have emerged as promising therapeutic molecules due to their remarkable resistance to proteolysis and performance to penetrate cells. The all-hydrocarbon peptide stapling technique
Externí odkaz:
https://doaj.org/article/7a71b664e86b4b37991939924003c6ef
Akademický článek
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Autor:
Hendrik Gruß, Rebecca C. Feiner, Ridhiwan Mseya, David C. Schröder, Michał Jewgiński, Kristian M. Müller, Rafał Latajka, Antoine Marion, Norbert Sewald
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 18, Iss 1, Pp 1-12 (2022)
The development of peptide stapling techniques to stabilise α-helical secondary structure motifs of peptides led to the design of modulators of protein–protein interactions, which had been considered undruggable for a long time. We disclose a nove
Externí odkaz:
https://doaj.org/article/b1e73b21829c4343991dd07924fa3253
Autor:
Cuicui Li, Ni Zhao, Luyan An, Zhen Dai, Xiaoyi Chen, Fan Yang, Qidong You, Bin Di, Chi Hu, Lili Xu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2670-2684 (2021)
Lung cancers are the leading cause of cancer deaths worldwide and pose a grave threat to human life and health. Non-small cell lung cancer (NSCLC) is the most frequent malignancy occupying 80% of all lung cancer subtypes. Except for other mutations (
Externí odkaz:
https://doaj.org/article/541eb09ea22d4c1ab281e02ae7721f11
Akademický článek
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Publikováno v:
Molecules, Vol 28, Iss 7, p 3198 (2023)
In recent years, researchers have been exploring the potential of incorporating selenium into peptides, as this element possesses unique properties that can enhance the reactivity of these compounds. Selenium is a non-metallic element that has a simi
Externí odkaz:
https://doaj.org/article/84670521f9e14fd5b4a89e5cea81c60d
Autor:
Marc Mathieu, Origène Nyanguile
Publikováno v:
CHIMIA, Vol 75, Iss 6, Pp 539-542 (2021)
The new Energypolis campus brings together the skills of EPFL Valais-Wallis, HES-SO Valais-Wallis, and the Ark Foundation's services. Together these partners respond to today's major concerns in the domains of energy, health, and the environment cutt
Externí odkaz:
https://doaj.org/article/f4a80935290b44a4a6221598b4c02198
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Anoplin is a linear 10-amino acid amphipathic peptide (Gly-Leu-Leu-Lys-Arg-Ile-Lys-Thr-Leu-Leu-NH2) derived from the venom sac of the solitary wasp. It has broad antimicrobial activity, including an antibacterial one. However, the inhibition of bacte
Externí odkaz:
https://doaj.org/article/d07829918a0f42409c307b65ee05c824
Publikováno v:
Pharmaceuticals, Vol 15, Iss 10, p 1283 (2022)
Peptides play an important role in many fields, including immunology, medical diagnostics, and drug discovery, due to their high specificity and positive safety profile. However, for their delivery as active pharmaceutical ingredients, delivery vecto
Externí odkaz:
https://doaj.org/article/cc566cf062b24d15964290182d25facc
Akademický článek
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