Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Staphylococcus aureus / enzymology"'
Publikováno v:
FEMS Microbiology Reviews. 46(5)
Staphylococcus aureus is an important human and livestock pathogen that is well-protected against environmental insults by a thick cell wall. Accordingly, the wall is a major target of present-day antimicrobial therapy. Unfortunately, S. aureus has m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dris___01423::08ff500c8bf0962f31b30051034e0806
https://doi.org/10.1093/femsre/fuac025
https://doi.org/10.1093/femsre/fuac025
Publikováno v:
FEMS Microbiology Reviews. 46
Staphylococcus aureus is an important human and livestock pathogen that is well-protected against environmental insults by a thick cell wall. Accordingly, the wall is a major target of present-day antimicrobial therapy. Unfortunately, S. aureus has m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f66dd3fcc6c2ab5941a0ed3fc7bd21c
https://doi.org/10.1093/femsre/fuac025
https://doi.org/10.1093/femsre/fuac025
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, Vol. 49, No 4 (2021) pp. 2085-2101
Nucleic Acids Research, Vol. 49, No 4 (2021) pp. 2085-2101
Antibiotic resistance is a serious problem which may be caused by bacterial dormancy. It has been suggested that bacterial toxin–antitoxin systems induce dormancy. We analyzed the genome-wide role of Staphylococcus aureus endoribonuclease toxin Maz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::dc140b6c8cc68882fb3ac9053a80a605
https://pubmed.ncbi.nlm.nih.gov/33544858
https://pubmed.ncbi.nlm.nih.gov/33544858
Autor:
Julie Paoletti, Gilles Labesse, Olivier Dussurget, Marie Anne Nahori, Liliane Assairi, Sylvie Pochet, Muriel Gelin, Valérie Huteau
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2016, 124, pp.1041-1056. ⟨10.1016/j.ejmech.2016.10.033⟩
European Journal of Medicinal Chemistry, 2016, 124, pp.1041-1056. ⟨10.1016/j.ejmech.2016.10.033⟩
European Journal of Medicinal Chemistry, Elsevier, 2016, 124, pp.1041-1056. ⟨10.1016/j.ejmech.2016.10.033⟩
European Journal of Medicinal Chemistry, 2016, 124, pp.1041-1056. ⟨10.1016/j.ejmech.2016.10.033⟩
Increased resistance of pathogens to existing antibiotics necessitates the search for novel targets to develop potent antimicrobials. Biosynthetic pathways of several cofactors important for bacterial growth, such as nicotinamide adenine dinucleotide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e165d3eae566bd9b213507978bbd048a
https://doi.org/10.1016/j.ejmech.2016.10.033
https://doi.org/10.1016/j.ejmech.2016.10.033
Publikováno v:
Nucleic acids research
Nucleic Acids Research, Vol. 39, No 13 (2011) pp. 5597-610
Nucleic Acids Research
Nucleic Acids Research, Vol. 39, No 13 (2011) pp. 5597-610
Nucleic Acids Research
A gene encoding a putative DNA helicase from Staphylococcus aureus USA300 was cloned and expressed in Escherichia coli. The protein was purified to over 90% purity by chromatography. The purified enzyme, SauUSI, predominantly cleaves modified DNA con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e992eabed92d57268f94c6bd4c25013
Autor:
Claus Spitzfaden, Paul Homes, Andrew P. Fosberry, Jianzhong Huang, Martin Hibbs, Michael N. Gwynn, Anthony Shillings, Alexandre Wohlkonig, Andrew J. Theobald, Pan F. Chan, Velupillai Srikannathasan, Onkar M. P. Singh, Benjamin D. Bax
Fluoroquinolone drugs such as moxifloxacin kill bacteria by stabilizing the normally transient double-stranded DNA breaks created by bacterial type IIA topoisomerases. Previous crystal structures of Staphylococcus aureus DNA gyrase with asymmetric DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab10eeb8df12cca74374d1610c9aeae7
https://hdl.handle.net/20.500.14017/22db32c0-99c6-4908-a958-7283af6f9d72
https://hdl.handle.net/20.500.14017/22db32c0-99c6-4908-a958-7283af6f9d72
Autor:
Benjamin D. Bax, Pan F. Chan, Michael M. Hann, Michael N. Gwynn, Daniel R. Gentry, Ceri J. Lewis, Jo J. Jones, Claus Spitzfaden, Andrew P. Fosberry, Martin Hibbs, Earl May, Kristin K. Brown, Alexandre Wohlkonig, Drake S. Eggleston, Onkar M. P. Singh, Alan Joseph Hennessy, Andrew J. Theobald, Fabrice Gorrec, Martin R. Saunders, Anthony Shillings, Emma J. Jones, Carol Shen, Neil D. Pearson, Jianzhong Huang, Ilaria Giordano
Despite the success of genomics in identifying new essential bacterial genes, there is a lack of sustainable leads in antibacterial drug discovery to address increasing multidrug resistance. Type IIA topoisomerases cleave and religate DNA to regulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ea159ed95a9dbead771494c8d86bdb2
https://doi.org/10.1038/nature09197
https://doi.org/10.1038/nature09197
Publikováno v:
Journal of Infectious Diseases, vol. 163, no. 3, pp. 514-523
In vitro and in vivo activity of amoxicillin and penicillin G alone or combined with a penicillinase inhibitor (clavulanate) were tested against five isogenic pairs of methicillin-resistant Staphylococcus aureus (MRSA) producing or not producing peni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b35d34600bed7946b44594fe0b083b
https://doi.org/10.1093/infdis/163.3.514
https://doi.org/10.1093/infdis/163.3.514
Autor:
Georg Peters, Anke Schmidt, Daniel Pablo Lew, Richard A. Proctor, Barbara C. Kahl, C. von Eiff, Stefan Emler, Pierre Vaudaux
Publikováno v:
Clinical Infectious Diseases, Vol. 29, No 4 (1999) pp. 932-934
Small-colony variants (SCVs) of Staphylococcus aureus cause persistent and relapsing infections. Relatively little is known regarding infections caused by SCVs of coagulase-negative staphylococci. We report two cases of pacemaker electrode infections
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6691d3cc69d5f72439bddf9e8ed51124
https://doi.org/10.1086/520462
https://doi.org/10.1086/520462
Publikováno v:
Journal of Infectious Diseases, vol. 177, no. 1, pp. 146-154
Beta-lactams active against methicillin-resistant Staphylococcus aureus (MRSA) must resist penicillinase hydrolysis and bind penicillin-binding protein 2A (PBP 2A). Cefamandole might share these properties. When tested against 2 isogenic pairs of MRS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcabdeb96ddc2447018671d59479c939
https://pubmed.ncbi.nlm.nih.gov/9419181
https://pubmed.ncbi.nlm.nih.gov/9419181