Daptomycin Physiology-Based Pharmacokinetic Modeling to Predict Drug Exposure and Pharmacodynamics in Skin and Bone Tissues

Autor: Romain Garreau, Damien Montange, Antoine Grillon, François Jehl, Tristan Ferry, Laurent Bourguignon, Sylvain Goutelle

Publikováno v: Clinical Pharmacokinetics
Clinical Pharmacokinetics, 2022, 61 (10), pp.1443-1456. ⟨10.1007/s40262-022-01168-5⟩

International audience; Background and objective: Daptomycin has been recommended in the treatment of bone and joint infection. Previous work showed that the approved dosage of daptomycin may be insufficient to achieve optimal exposure in patients wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b6f6222362845aad3fe52a40ec065f
https://doi.org/10.1007/s40262-022-01168-5

Staphylococcus aureus résistant à la méticilline : 15 ans de surveillance moléculaire en Suisse romande [Methicillin-resistant Staphylococcus aureus: 15 years of molecular epidemiology in Western Switzerland]

Autor: Blanc, D.S., Grandbastien, B., Bally, F., Lienhard, R., Tritten, M.L., Clerc, O., Fracheboud, D., Pfister, S., Chuard, C., Burr, M., Schmiedel, Y., Liassine, N., Jost, G., Togni, G., Di Lorenzo, V., Jayol, A., Prod'hom, G., Greub, G., Senn, L.

Publikováno v: Revue medicale suisse, vol. 18, no. 777, pp. 724-728

Since the introduction of antibiotics, successive waves of Staphylococcus aureus clones occurred, each one having characteristic susceptibility pattern to antibiotics and virulence factors. We report here the results of a molecular epidemiological su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1900::1f47ef1c4cfaf767ca40b9c939904b7e
https://serval.unil.ch/resource/serval:BIB_2931EA6F12A4.P001/REF.pdf

Topical niclosamide (ATx201) reduces Staphylococcus aureus colonization and increases Shannon diversity of the skin microbiome in atopic dermatitis patients in a randomized, double-blind, placebo-controlled Phase 2 trial

Autor: Anne Weiss, Emilie Delavenne, Carina Matias, Heimo Lagler, Daniel Simon, Ping Li, Jon U. Hansen, Teresa Pires dos Santos, Bimal Jana, Petra Priemel, Christine Bangert, Martin Bauer, Sabine Eberl, Alina Nussbaumer‐Pröll, Zoe Anne Österreicher, Peter Matzneller, Tamara Quint, Maria Weber, Hanne Mørck Nielsen, Thomas Rades, Helle Krogh Johansen, Henrik Westh, Wooseong Kim, Eleftherios Mylonakis, Christian Friis, Luca Guardabassi, John Pace, Carina Vingsbo Lundberg, Fatima M'Zali, Pascal Butty, Nikolaj Sørensen, Henrik Bjørn Nielsen, Rasmus Toft‐Kehler, Emma Guttman‐Yassky, Georg Stingl, Markus Zeitlinger, Morten Sommer

Publikováno v: Weiss, A, Delavenne, E, Matias, C, Lagler, H, Simon, D, Li, P, Hansen, J U, Dos Santos, T P, Jana, B, Priemel, P, Bangert, C, Bauer, M, Eberl, S, Nussbaumer-Pröll, A, Anne Österreicher, Z, Matzneller, P, Quint, T, Weber, M, Nielsen, H M, Rades, T, Johansen, H K, Westh, H, Kim, W, Mylonakis, E, Friis, C, Guardabassi, L, Pace, J, Lundberg, C V, M'Zali, F, Butty, P, Sørensen, N, Nielsen, H B, Toft-Kehler, R, Guttman-Yassky, E, Stingl, G, Zeitlinger, M & Sommer, M 2022, ' Topical niclosamide (ATx201) reduces Staphylococcus aureus colonization and increases Shannon diversity of the skin microbiome in atopic dermatitis patients in a randomized, double-blind, placebo-controlled Phase 2 trial ', Clinical and Translational Medicine, vol. 12, no. 5, e790 . https://doi.org/10.1002/ctm2.790

BACKGROUND: In patients with atopic dermatitis (AD), Staphylococcus aureus frequently colonizes lesions and is hypothesized to be linked to disease severity and progression. Treatments that reduce S. aureus colonization without significantly affectin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a844900e8190b0cef1d0338698328b6
https://pubmed.ncbi.nlm.nih.gov/35542966

Topical corticosteroids reduce the density of Staphylococcus aureus in hand eczema

Autor: P S Andersen, Niels E Ebbehøj, Tove Agner, Line Brok Nørreslet, S M Edslev, Anne Bregnhøj, Mette Sommerlund

Publikováno v: Nørreslet, L B, Edslev, S M, Bregnhøj, A, Sommerlund, M, Ebbehøj, N E, Andersen, P S & Agner, T 2022, ' Topical corticosteroids reduce the density of Staphylococcus aureus in hand eczema ', Journal of the European Academy of Dermatology and Venereology, vol. 36, no. 4, pp. e318-e319 . https://doi.org/10.1111/jdv.17844
Nørreslet, L B, Edslev, S M, Bregnhøj, A, Sommerlund, M, Ebbehøj, N E, Andersen, P S & Agner, T 2022, ' Topical corticosteroids reduce the density of Staphylococcus aureus in hand eczema ', Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 36, no. 4, pp. E318-E319 . https://doi.org/10.1111/jdv.17844

Hand eczema (HE) is a prevalent inflammatory skin disease(1). Staphylococcus aureus (S. aureus) is cultured from >50% of all HE cases, and its presence has been associated with disease severity(2-5), although the causal relationship remains unresolve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c40440c1a4593a9a21a96081601f3869
https://curis.ku.dk/portal/da/publications/topical-corticosteroids-reduce-the-density-of-staphylococcus-aureus-in-hand-eczema(0f37ef64-0a31-45cd-9f4b-1f493fa9f6a4).html

Rubor, calor, dolor, tumor : infections de la peau et des tissus mous [Rubor, calor, dolor, tumor : skin and soft tissue infections]

Autor: Kampouri, E., Filippidis, P., Lhopitallier, L., Pham, T.T., Schuhler, C., Toutous Trellu, L., Mombelli, M., Huttner, B.

Publikováno v: Revue medicale suisse, vol. 16, no. 690, pp. 732-738

Skin infections are a frequent cause of consultation, yet the diagnosis can be challenging for physicians. Microbiological documentation is rare, and empiric antibiotic regimens should cover the most commonly identified bacteria, i.e. streptococci St

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1900::87c50424c53b5191a3d4cba7066cd9c0
https://serval.unil.ch/notice/serval:BIB_D43F306B1188