Výsledky vyhledávání - "Stanton L Gerson"

Akademický článek

15-PGDH regulates hematopoietic and gastrointestinal fitness during aging.

Autor: Won Jin Ho, Julianne N P Smith, Young Soo Park, Matthew Hadiono, Kelsey Christo, Alvin Jogasuria, Yongyou Zhang, Alyssia V Broncano, Lakshmi Kasturi, Dawn M Dawson, Stanton L Gerson, Sanford D Markowitz, Amar B Desai

Publikováno v: PLoS ONE, Vol 17, Iss 5, p e0268787 (2022)

Emerging evidence implicates the eicosanoid molecule prostaglandin E2 (PGE2) in conferring a regenerative phenotype to multiple organ systems following tissue injury. As aging is in part characterized by loss of tissue stem cells' regenerative capaci

Externí odkaz: https://doaj.org/article/1d5311542b3a499489eef5c722b323e2

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Akademický článek

Mismatch repair deficient hematopoietic stem cells are preleukemic stem cells.

Autor: Yulan Qing, Stanton L Gerson

Publikováno v: PLoS ONE, Vol 12, Iss 8, p e0182175 (2017)

Whereas transformation events in hematopoietic malignancies may occur at different developmental stages, the initial mutation originates in hematopoietic stem cells (HSCs), creating a preleukemic stem cell (PLSC). Subsequent mutations at either stem

Externí odkaz: https://doaj.org/article/7715ef6d0d1a488c8e8fb209c61057f6

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Akademický článek

A Fluorescent Probe to Measure DNA Damage and Repair.

Autor: Allison G Condie, Yan Yan, Stanton L Gerson, Yanming Wang

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0131330 (2015)

DNA damage and repair is a fundamental process that plays an important role in cancer treatment. Base excision repair (BER) is a major repair pathway that often leads to drug resistance in DNA-targeted cancer chemotherapy. In order to measure BER, we

Externí odkaz: https://doaj.org/article/b5b2733afa784dd693cca428b5e410e6

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Akademický článek

Derivation of a myeloid cell-binding adenovirus for gene therapy of inflammation.

Autor: Michael O Alberti, Justin C Roth, Mourad Ismail, Yuko Tsuruta, Edward Abraham, Larisa Pereboeva, Stanton L Gerson, David T Curiel

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e37812 (2012)

The gene therapy field is currently limited by the lack of vehicles that permit efficient gene delivery to specific cell or tissue subsets. Native viral vector tropisms offer a powerful platform for transgene delivery but remain nonspecific, requirin

Externí odkaz: https://doaj.org/article/285f7b74aa434245849e2062d8547d0e

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Akademický článek

Synergistic actions of hematopoietic and mesenchymal stem/progenitor cells in vascularizing bioengineered tissues.

Autor: Eduardo K Moioli, Paul A Clark, Mo Chen, James E Dennis, Helaman P Erickson, Stanton L Gerson, Jeremy J Mao

Publikováno v: PLoS ONE, Vol 3, Iss 12, p e3922 (2008)

Poor angiogenesis is a major road block for tissue repair. The regeneration of virtually all tissues is limited by angiogenesis, given the diffusion of nutrients, oxygen, and waste products is limited to a few hundred micrometers. We postulated that

Externí odkaz: https://doaj.org/article/045d30513fd44c89870ae467a2e17a87

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Akademický článek

Impact of age, antiretroviral therapy, and cancer on epigenetic aging in people living with HIV

Autor: Yulan Qing, Ricky Chan, Pingfu Fu, Jennifer Cullen, Alexander Miron, Jeffrey M. Jacobson, John Pink, Stanton L. Gerson

Publikováno v: Cancer Medicine, Vol 12, Iss 9, Pp 11010-11019 (2023)

Abstract Background Premature aging has been identified as a global risk factor for cancer. Causes of premature aging are multifactorial, including inflammation, infection, chronic stress, and lifestyle factors. Method We evaluated whether premature

Externí odkaz: https://doaj.org/article/893f83ef82564bca992608392b342d0d

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