Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Stanley Y Shaw"'
Autor:
Uri Kartoun, Kathleen E Corey, Tracey G Simon, Hui Zheng, Rahul Aggarwal, Kenney Ng, Stanley Y Shaw
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186301 (2017)
BACKGROUND AND AIMS:Accurate assessment of the risk of mortality following a cirrhosis-related admission can enable health-care providers to identify high-risk patients and modify treatment plans to decrease the risk of mortality. METHODS:We develope
Externí odkaz:
https://doaj.org/article/98af8f0b5812407a9b8a2a3482d81666
Autor:
Scott B Vafai, Emily Mevers, Kathleen W Higgins, Yevgenia Fomina, Jianming Zhang, Anna Mandinova, David Newman, Stanley Y Shaw, Jon Clardy, Vamsi K Mootha
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162686 (2016)
Deficiency of mitochondrial complex I is encountered in both rare and common diseases, but we have limited therapeutic options to treat this lesion to the oxidative phosphorylation system (OXPHOS). Idebenone and menadione are redox-active molecules c
Externí odkaz:
https://doaj.org/article/1189c546b7fa4d0dbe61eebbf1fa260a
Autor:
Bernard Khor, John D Gagnon, Gautam Goel, Marly I Roche, Kara L Conway, Khoa Tran, Leslie N Aldrich, Thomas B Sundberg, Alison M Paterson, Scott Mordecai, David Dombkowski, Melanie Schirmer, Pauline H Tan, Atul K Bhan, Rahul Roychoudhuri, Nicholas P Restifo, John J O'Shea, Benjamin D Medoff, Alykhan F Shamji, Stuart L Schreiber, Arlene H Sharpe, Stanley Y Shaw, Ramnik J Xavier
Publikováno v:
eLife, Vol 4 (2015)
The balance between Th17 and T regulatory (Treg) cells critically modulates immune homeostasis, with an inadequate Treg response contributing to inflammatory disease. Using an unbiased chemical biology approach, we identified a novel role for the dua
Externí odkaz:
https://doaj.org/article/8d529be262854d4f87b10c044565271a
Autor:
Katherine P Liao, Ashwin N Ananthakrishnan, Vishesh Kumar, Zongqi Xia, Andrew Cagan, Vivian S Gainer, Sergey Goryachev, Pei Chen, Guergana K Savova, Denis Agniel, Susanne Churchill, Jaeyoung Lee, Shawn N Murphy, Robert M Plenge, Peter Szolovits, Isaac Kohane, Stanley Y Shaw, Elizabeth W Karlson, Tianxi Cai
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136651 (2015)
BACKGROUND:Typically, algorithms to classify phenotypes using electronic medical record (EMR) data were developed to perform well in a specific patient population. There is increasing interest in analyses which can allow study of a specific outcome a
Externí odkaz:
https://doaj.org/article/843e2538294445f0890086f96442a221
Autor:
Zongqi Xia, Elizabeth Secor, Lori B Chibnik, Riley M Bove, Suchun Cheng, Tanuja Chitnis, Andrew Cagan, Vivian S Gainer, Pei J Chen, Katherine P Liao, Stanley Y Shaw, Ashwin N Ananthakrishnan, Peter Szolovits, Howard L Weiner, Elizabeth W Karlson, Shawn N Murphy, Guergana K Savova, Tianxi Cai, Susanne E Churchill, Robert M Plenge, Isaac S Kohane, Philip L De Jager
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78927 (2013)
To optimally leverage the scalability and unique features of the electronic health records (EHR) for research that would ultimately improve patient care, we need to accurately identify patients and extract clinically meaningful measures. Using multip
Externí odkaz:
https://doaj.org/article/8285f873f4554290bdc8d6632a5788a6
Autor:
Nelson W Chong, Andrea L Koekemoer, Samir Ounzain, Nilesh J Samani, Jordan T Shin, Stanley Y Shaw
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40966 (2012)
BackgroundSTARS (STriated muscle Activator of Rho Signaling) is a sarcomeric protein expressed early in cardiac development that acts as an acute stress sensor for pathological remodeling. However the role of STARS in cardiac development and function
Externí odkaz:
https://doaj.org/article/5ca74fa7ae754439ba213b105f25620f
Autor:
Edwin Choy, Roman Yelensky, Sasha Bonakdar, Robert M Plenge, Richa Saxena, Philip L De Jager, Stanley Y Shaw, Cara S Wolfish, Jacqueline M Slavik, Chris Cotsapas, Manuel Rivas, Emmanouil T Dermitzakis, Ellen Cahir-McFarland, Elliott Kieff, David Hafler, Mark J Daly, David Altshuler
Publikováno v:
PLoS Genetics, Vol 4, Iss 11, p e1000287 (2008)
Lymphoblastoid cell lines (LCLs), originally collected as renewable sources of DNA, are now being used as a model system to study genotype-phenotype relationships in human cells, including searches for QTLs influencing levels of individual mRNAs and
Externí odkaz:
https://doaj.org/article/047c23ef1a3046c9b9e8bb7f9e7069bf
Autor:
Eric A. Secemsky, Neel M. Butala, Uri Kartoun, Sadiqa Mahmood, Jason H. Wasfy, Kevin F. Kennedy, Stanley Y. Shaw, Robert W. Yeh
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 10 (2016)
BackgroundContemporary rates of oral anticoagulant (OAC) therapy and associated outcomes among patients undergoing percutaneous coronary intervention (PCI) have been poorly described. Methods and ResultsUsing data from an integrated health care syste
Externí odkaz:
https://doaj.org/article/2206913397b949e589c30c7425668b9e
Autor:
Rebecca L. Walker, Hera Vlamakis, Jonathan Wei Jie Lee, Luke A. Besse, Vanessa Xanthakis, Ramachandran S. Vasan, Stanley Y. Shaw, Ramnik J. Xavier
Publikováno v:
Genome Medicine
Genome Medicine, Vol 13, Iss 1, Pp 1-16 (2021)
Genome Medicine, Vol 13, Iss 1, Pp 1-16 (2021)
Background The human gut harbors trillions of microbes that play dynamic roles in health. While the microbiome contributes to many cardiometabolic traits by modulating host inflammation and metabolism, there is an incomplete understanding regarding t
Autor:
Jiehuan Sun, Victor M. Castro, Sicong Huang, David R. Gagnon, Ashwin N. Ananthakrishnan, Tianxi Cai, Jacqueline Honerlaw, Yuk-Lam Ho, Isaac S. Kohane, Peter Szolovits, Sheng Yu, Susanne Churchill, Yichi Zhang, Stanley Y. Shaw, Zongqi Xia, Shawn N. Murphy, Robert M. Plenge, Katherine P. Liao, J. Michael Gaziano, Nicholas Link, Kelly Cho, Elizabeth W. Karlson, Chuan Hong, Tianrun Cai, Vivian S. Gainer, Guergana Savova, Christopher J. O'Donnell, Jie Huang
Publikováno v:
Nat Protoc
Phenotypes are the foundation for clinical and genetic studies of disease risk and outcomes. The growth of biobanks linked to electronic medical record (EMR) data has both facilitated and increased the demand for efficient, accurate, and robust appro