Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Stanley Van"'
Autor:
Roger Mulet-Lazaro, Stanley van Herk, Margit Nuetzel, Aniko Sijs-Szabo, Noelia Díaz, Katherine Kelly, Claudia Erpelinck-Verschueren, Lucia Schwarzfischer-Pfeilschifter, Hanna Stanewsky, Ute Ackermann, Dagmar Glatz, Johanna Raithel, Alexander Fischer, Sandra Pohl, Anita Rijneveld, Juan M. Vaquerizas, Christian Thiede, Christoph Plass, Bas J. Wouters, Ruud Delwel, Michael Rehli, Claudia Gebhard
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Leukemias with ambiguous lineage comprise several loosely defined entities, often without a clear mechanistic basis. Here, we extensively profile the epigenome and transcriptome of a subgroup of such leukemias with CpG Island Methylator Phen
Externí odkaz:
https://doaj.org/article/df577d6f414846109f3f3dcf2f2865a4
Autor:
Sophie Ottema, Roger Mulet-Lazaro, Claudia Erpelinck-Verschueren, Stanley van Herk, Marije Havermans, Andrea Arricibita Varea, Michael Vermeulen, H. Berna Beverloo, Stefan Gröschel, Torsten Haferlach, Claudia Haferlach, Bas J. Wouters, Eric Bindels, Leonie Smeenk, Ruud Delwel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Chromosome rearrangements can be a cause of altered oncogene expression in cancer, such as a 3q26 translocation in some acute myeloid leukemias (AML) that leads to overexpression of EVI1. Here the authors engineer this rearrangement in a cell line an
Externí odkaz:
https://doaj.org/article/7df6196de175464e8b50bb614eba9c97
Autor:
Berent, Gerald P, Kelly, Ronald R, Rizzo, Susan P, Chen, Zhong, Schueler-Choukairi, Tanya, Persky, Kimberly, Schmitz, Kathryn L, Horn, Stanley Van
Publikováno v:
Journal of Deaf Studies & Deaf Education; Apr2024, Vol. 29 Issue 2, p158-169, 12p
Publikováno v:
South African Journal of Business Management, Vol 50, Iss 1, Pp e1-e14 (2019)
Background: Technology-based entrepreneurial businesses (TBEBs) have been identified as major contributors to economic growth and job creation in most global economies. Aim: The objective of this study was to empirically test the relationships betwe
Externí odkaz:
https://doaj.org/article/7a187251f8204f2186c0ddcaa31a95d9
Autor:
Alexander Fischer, Roger Mulet-Lazaro, Margit Nützel, Stanley van Herk, Hanna Stanewsky, Ute Ackermann, Edith Reuschel, Nicholas Strieder, Inmaculada Hernandez-Lopez, Wolfgang Herr, Peter J.M. Valk, Michael Rehli, Ruud Delwel, Claudia Gebhard
Publikováno v:
Blood. 140:3379-3380
Autor:
Dorien Pastoors, Marije Havermans, Remco Hoogenboezem, Roger Mulet-Lazaro, Duncan Brian, Leonie Smeenk, Claudia Erpelinck-Verschueren, Stanley van Herk, Bas Wouters, Jeroen A.A. Demmers, Johannes Zuber, Tariq Enver, Richard WJ Groen, Eric Bindels, Ruud Delwel
Publikováno v:
Blood. 140:83-84
Autor:
Marije Havermans, Eric M.J. Bindels, Leonie Smeenk, Peter J. M. Valk, Stanley van Herk, Claudia Erpelinck, Roger Mulet-Lazaro, H. Berna Beverloo, Ruud Delwel, Robert van der Helm, Sophie Ottema, Torsten Haferlach, Claudia Haferlach, Tim Grob
Publikováno v:
Blood, 136(2), 224-234. American Society of Hematology
Acute myeloid leukemia (AML) with inv(3)/t(3;3)(q21q26) is a distinct World Health Organization recognized entity, characterized by its aggressive course and poor prognosis. In this subtype of AML, the translocation of a GATA2 enhancer (3q21) to MECO
Managing multiple sclerosis, with all the associated problems of a progressive chronic disease, requires special knowledge on the part of the clinician. From which drugs to prescribe for an acute attack, to the use of new drugs available to help cont
Autor:
H. Berna Beverloo, Ruud Delwel, Eric Bindels, Marije Havermans, Sophie Ottema, Stefan Gröschel, Michael Vermeulen, Bas J. Wouters, Torsten Haferlach, Leonie Smeenk, Claudia A.J. Erpelinck-Verschueren, Claudia Haferlach, Roger Mulet-Lazaro, Andrea Arricibita Varea, Stanley van Herk
Publikováno v:
Nature Communications, 12(1):5679. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Chromosomal rearrangements are a frequent cause of oncogene deregulation in human malignancies. Overexpression of EVI1 is found in a subgroup of acute myeloid leukemia (AML) with 3q26 chromosomal rearrangements, which is often therapy resistant. In A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39af26ea606ee42cf0d14c739198eca
https://pure.eur.nl/en/publications/04f21b77-cbaa-43f7-a02e-7d978a9554bd
https://pure.eur.nl/en/publications/04f21b77-cbaa-43f7-a02e-7d978a9554bd
Autor:
Ruud Delwel, Eric M.J. Bindels, Sophie Ottema, Marije Havermans, Emery H. Bresnick, François G. Kavelaars, Andrea Arricibita Varea, Johannes Zuber, Alex Kentsis, Remco Hoogenboezem, Anja Ebert, Roger Mulet-Lazaro, Tim Grob, Daniel R. Matson, Dorien Pastoors, Michaela Fellner, Stanley van Herk, Claudia A.J. Erpelinck-Verschueren, Leonie Smeenk
Publikováno v:
Cancer Discov
Cancer Discovery, 11(11), 2868-2883. American Association for Cancer Research Inc.
Cancer Discovery, 11(11), 2868-2883. American Association for Cancer Research Inc.
In acute myeloid leukemia (AML) with inv(3)(q21;q26) or t(3;3)(q21;q26), a translocated GATA2 enhancer drives oncogenic expression of EVI1. We generated an EVI1-GFP AML model and applied an unbiased CRISPR/Cas9 enhancer scan to uncover sequence motif