Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Stanley T. Bayley"'
Autor:
Stanley T. Bayley, Chao-Zhong Song, Janey Symington, Paul M. Loewenstein, Maurice Green, Rozalia Pusztai, Karoly Toth, Akira Nishikawa, Christopher J. Tierney, Qing-quan Tang
Publikováno v:
Journal of Biological Chemistry. 270:23263-23267
The human adenovirus E1A 243R protein (243 residues) transcriptionally represses a set of cellular genes that regulate cellular growth and differentiation. We describe two lines of evidence that E1A repression does not require cellular protein synthe
Autor:
Stanley T. Bayley, Joe S. Mymryk
Publikováno v:
Journal of General Virology. 74:2131-2141
By immunoprecipitating protein products from virus-infected baby rat kidney (BRK) cells with specific antibodies, we found that the smaller, 243 residue (243R) E1A protein of human adenovirus 5 (Ad5) activated expression of the virus genes for E1B 55
Publikováno v:
Journal of Virology. 67:2944-2949
From previous studies on the induction of DNA synthesis in quiescent primary baby rat kidney cells by adenovirus type 5 (Ad5) E1A deletion mutants, we concluded that induction is prevented only when cellular proteins p300 and pRb are both uncomplexed
Autor:
Ute Schaeper, Stanley T. Bayley, M La Regina, G. Chinnadurai, Thirugnana Subramanian, Janice M. Boyd
Publikováno v:
The EMBO Journal. 12:469-478
We have examined a series of small deletion mutants within exon 2 of the adenovirus 2/5 E1A oncogene product, the 243R protein, for immortalization, ras cooperative transformation, tumorigenesis and metastasis. Compared with wild-type 243R, various d
Publikováno v:
Molecular Biology of the Cell. 3:1107-1115
We have used deletion mutants to define the regions in Ad5 E1A proteins necessary to suppress differentiation of mouse BC3H1 myoblasts. We examined the differentiation of cells infected at a low multiplicity with viruses containing the E1A deletions
Autor:
Senthil K. Muthuswamy, Stanley T. Bayley, Raymond W. H. Lee, Janice D. Oakes, Joe S. Mymryk, Pietro D'Amico
Publikováno v:
Biochemistry and Cell Biology. 70:1268-1276
Mouse BC3H1 myoblasts were stably transfected with the adenovirus 5 E1A gene. One clonal line, BC3E7, was found to differ in some important respects from those previously reported for E1A-transformed myoblasts. In contrast to BC3H1 cells which differ
Autor:
Stanley T. Bayley, Joe S. Mymryk
Publikováno v:
Virus research. 33(1)
Adenovirus type 5 (Ad5) mutant dl 520, which produces only the smaller 243 residue (243R) E1A protein, induced efficient production of the viral E2A 72-kDa DNA binding protein (DBP) in human KB cells, but not in human WI38, 143, or HeLa cells. In tra
Autor:
Joe S. Mymryk, Stanley T. Bayley
Publikováno v:
Journal of virology. 67(12)
We have constructed an adenovirus type 5 (Ad5) E1A mutant, dl1119/520, that produces essentially only exon 2 of the major E1A proteins. In infected primary baby rat kidney cells, this mutant induced expression of the E1B 55-kDa protein, and in infect
Publikováno v:
The Journal of general virology. 74
Human adenovirus early region 1A (E1A) proteins act as transcriptional regulators and function in the control of DNA synthesis and cell transformation. Little is known about how these viral products are functionally regulated. E1A proteins of adenovi
Autor:
Silvia Bacchetti, Dominique Barbeau, Philip E. Branton, Stanley T. Bayley, Richard C. Marcellus
Publikováno v:
Biochemistry and cell biology = Biochimie et biologie cellulaire. 70(10-11)
Human adenovirus E1A proteins and oncogene products of several other DNA tumour viruses derive much of their oncogenic potential from interactions with cellular polypeptides. E1A proteins form complexes with p105Rb and a related p107 polypeptide, and