Zobrazeno 1 - 10
of 364
pro vyhledávání: '"Stanley T, Crooke"'
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 832-844 (2023)
Single-stranded phosphorothioate oligonucleotides (PS-oligos) can activate TLR9, leading to an innate immune response. This can occur with PS-oligos containing unmethylated CpG sites, the canonical motif, or PS-oligos that do not contain those motifs
Externí odkaz:
https://doaj.org/article/4f3cba99e8d34c71ad01fbcae30d0bc0
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 814-828 (2022)
Phosphorothioate modified antisense oligonucleotides (PS-ASOs) can reduce gene expression through hybridization to target RNAs and subsequent cleavage by RNase H1. Target reduction through this mechanism is influenced by numerous features of the RNA,
Externí odkaz:
https://doaj.org/article/b8db0e97a095403da9cdcbaabec961fa
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 13, Iss , Pp 686-698 (2018)
Chemically modified antisense oligonucleotides with phosphorothioate linkages (PS-ASOs) mediate site-specific cleavage of RNA by RNase H1 and are broadly used as research and therapeutic tools. PS-ASOs can enter cells via endocytic pathways and escap
Externí odkaz:
https://doaj.org/article/27a1f8f1d4ef41279d29f7ef823a2e20
Publikováno v:
Nucleic Acid Therapeutics. 33:95-107
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::049cdb549c72a0b364f5a1a7e226fdad
https://doi.org/10.1089/nat.2022.0067
https://doi.org/10.1089/nat.2022.0067
Autor:
Lingdi Zhang, Xue-hai Liang, Cheryl Li De Hoyos, Michael Migawa, Joshua G. Nichols, Graeme Freestone, Jun Tian, Punit P. Seth, Stanley T. Crooke
Publikováno v:
Nucleic Acid Therapeutics. 32:401-411
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d010ee80d944483c78c624b02605c89a
https://doi.org/10.1089/nat.2022.0005
https://doi.org/10.1089/nat.2022.0005
Autor:
Lingdi, Zhang, Karla D, Bernardo, Timothy A, Vickers, Jun, Tian, Xue-Hai, Liang, Stanley T, Crooke
Publikováno v:
Nucleic Acid Therapeutics. 32:280-299
RNase H1-dependent phosphorothioate oligonucleotides (PS-ASOs) have been developed to treat various diseases through specific degradation of target RNAs. Although many factors or features of RNA and PS-ASOs have been demonstrated to affect antisense
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb03ace940b5cc82808a2687b1c11502
https://doi.org/10.1089/nat.2021.0107
https://doi.org/10.1089/nat.2021.0107
Publikováno v:
Nucleic Acids Research. 50:8107-8126
Non-CpG PS-ASOs can activate the innate immune system, leading to undesired outcomes. This response can vary—in part—as a function of 2′modifications and sequence. Here we investigated the molecular steps involved in the varied effects of PS-AS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63cebe7fd7d78a595a42e25c1fe51626
https://doi.org/10.1093/nar/gkac618
https://doi.org/10.1093/nar/gkac618
Autor:
Stanley T Crooke
Publikováno v:
Nucleic Acids Research. 50:7216-7223
For more than three decades, Ionis Pharmaceutics has pursued the challenging mission of creating a new platform for drug discovery. To overcome the numerous challenges faced required the integration of innovation across many scientific areas, despite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a43dfc6a05a28da23e10adb26476c110
https://doi.org/10.1093/nar/gkac526
https://doi.org/10.1093/nar/gkac526
Autor:
Joseph G. Gleeson, C. Frank Bennett, Jeffrey B. Carroll, Tracy Cole, Julie Douville, Sarah Glass, Cedrik Tekendo-Ngongang, Amy C. Williford, Stanley T. Crooke
Publikováno v:
Nature Medicine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c76c5c5bd1374e19b6b836064d44c2d
https://doi.org/10.1038/s41591-023-02335-2
https://doi.org/10.1038/s41591-023-02335-2
Autor:
Stanley T. Crooke
Publikováno v:
Trends in Molecular Medicine. 28:87-96
Patients with ultrarare diseases present unique challenges to the health care systems of developed economies that demand novel approaches, beginning with achieving a diagnosis and concluding with long-term treatment. The challenges derive from number
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49215abcbc0fccacc787d6cab49b85bc
https://doi.org/10.1016/j.molmed.2021.12.002
https://doi.org/10.1016/j.molmed.2021.12.002