Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Stanley R. Krystek"'
Autor:
Yan Shi, Ying Wang, Wei Meng, Robert P. Brigance, Denis E. Ryono, Scott Bolton, Hao Zhang, Sean Chen, Rebecca Smirk, Shiwei Tao, Joseph A. Tino, Kristin N. Williams, Richard Sulsky, Laura Nielsen, Bruce Ellsworth, Michael K. Y. Wong, Jung-Hui Sun, Leslie W. Leith, Dawn Sun, Dauh-Rurng Wu, Anuradha Gupta, Richard Rampulla, Arvind Mathur, Bang-Chi Chen, Aiying Wang, Helen G. Fuentes-Catanio, Lori Kunselman, Michael Cap, Jacob Zalaznick, Xiaohui Ma, Heng Liu, Joseph R. Taylor, Rachel Zebo, Beverly Jones, Stephen Kalinowski, Joann Swartz, Ada Staal, Kevin O’Malley, Lisa Kopcho, Jodi K. Muckelbauer, Stanley R. Krystek, Steven A. Spronk, Jovita Marcinkeviciene, Gerry Everlof, Xue-Qing Chen, Carrie Xu, Yi-Xin Li, Robert A. Langish, Yanou Yang, Qi Wang, Kamelia Behnia, Aberra Fura, Evan B. Janovitz, Nicola Pannacciulli, Steven Griffen, Bradley A. Zinker, John Krupinski, Mark Kirby, Jean Whaley, Robert Zahler, Joel C. Barrish, Jeffrey A. Robl, Peter T. W. Cheng
Publikováno v:
Journal of Medicinal Chemistry. 65:4291-4317
Autor:
Kyle Trainor, Colleen M. Doyle, Avril Metcalfe-Roach, Julia Steckner, Daša Lipovšek, Heather Malakian, David Langley, Stanley R. Krystek Jr., Elizabeth M. Meiering
Publikováno v:
Journal of molecular biology. 434(2)
Structural heterogeneity often constrains the characterization of aggregating proteins to indirect or low-resolution methods, obscuring mechanistic details of association. Here, we report progress in understanding the aggregation of Adnectins, engine
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 86:1147-1156
Protein aggregation is a phenomenon that has attracted considerable attention within the pharmaceutical industry from both a developability standpoint (to ensure stability of protein formulations) and from a research perspective for neurodegenerative
Autor:
Yuanli Song, Stanley R. Krystek, Sergey Voronov, Zheng Jian Li, Jeff Beckman, Nesredin Mussa, Yan Gu, Naresh Chennamsetty
Publikováno v:
Analytical Chemistry. 90:2542-2547
Capillary gel electrophoresis using sodium dodecyl sulfate (CE-SDS) is used commercially to provide quantitative purity data for therapeutic protein characterization and release. In CE-SDS, proteins are denatured under reducing or nonreducing conditi
Autor:
Stanley R. Krystek, Robert F. Graziano, Richard Y.-C. Huang, Nathan J Felix, Mohan Srinivasan, Guodong Chen, Achal Pashine
Publikováno v:
mAbs. 10:95-103
TL1A, a tumor necrosis factor-like cytokine, is a ligand for the death domain receptor DR3. TL1A, upon binding to DR3, can stimulate lymphocytes and trigger secretion of proinflammatory cytokines. Therefore, blockade of TL1A/DR3 interaction may be a
Autor:
Kevin Fitzgerald, Svetlana Tertyshnikova, Lisa Moore, Lynn Bjerke, Ben Burley, Jian Cao, Pamela Carroll, Robert Choy, Steve Doberstein, Yves Dubaquie, Yvonne Franke, Jenny Kopczynski, Hendrik Korswagen, Stanley R Krystek, Nicholas J Lodge, Ronald Plasterk, John Starrett, Terry Stouch, George Thalody, Honey Wayne, Alexander van der Linden, Yongmei Zhang, Stephen G Walker, Mark Cockett, Judi Wardwell-Swanson, Petra Ross-Macdonald, Rachel M Kindt
Publikováno v:
PLoS Genetics, Vol 2, Iss 4, p e57 (2006)
We report here on a chemical genetic screen designed to address the mechanism of action of a small molecule. Small molecules that were active in models of urinary incontinence were tested on the nematode Caenorhabditis elegans, and the resulting phen
Externí odkaz:
https://doaj.org/article/1932641b9cd346b58d4f8941da49cf1f
Autor:
Brenda Stevens, Derek Bond, Hui Wei, Ty M. Brender, Susan H. Julien, Michael L. Gross, Jena Feiner, Johanna Harshman, Richard Y.-C. Huang, Guodong Chen, Nels Hamacher, Luciano Mueller, Lumelle A. Schneeweis, Preeti Sejwal, Jing Li, Stanley R. Krystek, Kristina Moore, Adrienne A. Tymiak, Daniel Cohen, Zheng Lin, Paul O. Sheppard, Claire Noriega
Publikováno v:
Analytical Chemistry. 89:2250-2258
Epitope mapping the specific residues of an antibody/antigen interaction can be used to support mechanistic interpretation, antibody optimization, and epitope novelty assessment. Thus, there is a strong need for mapping methods, particularly integrat
Autor:
Janet Dell-John, John D. Dimarco, Cheryl A. Rizzo, Mark E. Salvati, Steven H. Spergel, Gregory Scott Martin, Weifang Shan, Aaron Balog, Georgia Cornelius, Richard Rampulla, Marco M. Gottardis, Andrew Nation, Christian L. Holst, Liang Schweizer, Gregory D. Vite, Lana M. Rossiter, Ricardo M. Attar, David J. Fairfax, Thomas E. Spires, Stanley R. Krystek, George L. Trainor, Jack Z. Gougoutas
Publikováno v:
ACS Medicinal Chemistry Letters. 6:908-912
BMS-641988 (23) is a novel, nonsteroidal androgen receptor antagonist designed for the treatment of prostate cancer. The compound has high binding affinity for the AR and acts as a functional antagonist in vitro. BMS-641988 is efficacious in multiple
Autor:
Sibylle Herzer, Matthew Conover, Isha Chowdhary, Brian W. O’Mara, Stanley R. Krystek, Atul Bhangale, Lily Tsang, Shi-Yu Wang, Yan Yao, Siegfried Rieble, Gregory Barker
Publikováno v:
Biotechnology and Bioengineering. 112:1417-1428
A robust, economical process should leverage proven technology, yet be flexible enough to adopt emerging technologies which show significant benefit. Antibody and Fc-fusion processes may capitalize on the high selectivity of an affinity capture step
Autor:
Michael L. Doyle, Roxana E. Iacob, Richard Y.-C. Huang, Guodong Chen, Paul E. Morin, Hui Wei, Li Tao, Zheng Lin, Stanley R. Krystek, John R. Engen, Adrienne A. Tymiak
Publikováno v:
Expert Review of Proteomics. 12:159-169
Interleukin-23 (IL-23) is an important therapeutic target for the treatment of inflammatory diseases. Adnectins are targeted protein therapeutics that are derived from domain III of human fibronectin, and have similar protein scaffold to antibodies.