Zobrazeno 1 - 10
of 853
pro vyhledávání: '"Stanley Nattel"'
Autor:
Sandro Ninni, Rocio Vicario, Augustin Coisne, Eloise Woitrain, Amine Tazibet, Caitlin M. Stewart, Luis A. Diaz, James Robert White, Mohammed Koussa, Henri Dubrulle, Francis Juthier, Marie Jungling, André Vincentelli, Jean‐Louis Edme, Stanley Nattel, Menno de Winther, Frederic Geissmann, David Dombrowicz, Bart Staels, David Montaigne
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 17 (2024)
Background Cardiac surgery triggers sterile innate immune responses leading to postoperative complications. Clonal hematopoiesis (CH) is associated with short‐term inflammation‐mediated outcomes after cardiac surgery. The impact of CH on long‐t
Externí odkaz:
https://doaj.org/article/a1418df6d5004fd7b9ce2c224f10bced
Autor:
Francis J.A. Leblanc, Xuexin Jin, Kai Kang, Chang Jie Mick Lee, Juan Xu, Lina Xuan, Wenbo Ma, Hicham Belhaj, Marouane Benzaki, Neelam Mehta, Roger Sik Yin Foo, Svetlana Reilly, Chukwuemeka George Anene-Nzelu, Zhenwei Pan, Stanley Nattel, Baofeng Yang, Guillaume Lettre
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110660- (2024)
Summary: Atrial fibrillation (AF) is the most common arrhythmia in the world. Human genetics can provide strong AF therapeutic candidates, but the identification of the causal genes and their functions remains challenging. Here, we applied an AF fine
Externí odkaz:
https://doaj.org/article/f281466b8091436bb93efc88b9330056
Autor:
Sandrine Parent, Ramana Vaka, Yousef Risha, Clarissa Ngo, Pushpinder Kanda, Stanley Nattel, Saad Khan, David Courtman, Duncan J. Stewart, Darryl R. Davis
Publikováno v:
JCI Insight, Vol 8, Iss 15 (2023)
Almost half of patients recovering from open-chest surgery experience atrial fibrillation (AF) that results principally from inflammation in the pericardial space surrounding the heart. Given that postoperative AF is associated with increased mortali
Externí odkaz:
https://doaj.org/article/6ef884474dca479fb690d08f70f0be02
Autor:
Yuan Zhong, Kai Tang, Stanley Nattel, Ming Zhai, Shiyu Gong, Qing Yu, Yanxi Zeng, Guangxi E, Nuerbiyemu Maimaitiaili, Jun Wang, Yawei Xu, Wenhui Peng, Hailing Li
Publikováno v:
Redox Biology, Vol 60, Iss , Pp 102606- (2023)
Objectives: To determine the role of MYL4 regulation of lysosomal function and its disturbance in fibrotic atrial cardiomyopathy. Background: We have previously demonstrated that the atrial-specific essential light chain protein MYL4 is required for
Externí odkaz:
https://doaj.org/article/c4bf86d2d9d240459f26f3ae0618c0c3
Autor:
Patrick Vigneault, Sandrine Parent, Pushpinder Kanda, Connor Michie, Darryl R. Davis, Stanley Nattel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Strategies to improve the function of damaged hearts with progenitor cells have stalled. Here, the authors show that gene transfer of a calcium-dependent potassium channel enhances the functional properties and ability of explant-derived cells to imp
Externí odkaz:
https://doaj.org/article/840a9115e7784df6b8daa2ba58242d52
Autor:
Evan V. Jenkins, Dhani Dharmaprani, Madeline Schopp, Jing Xian Quah, Kathryn Tiver, Lewis Mitchell, Feng Xiong, Martin Aguilar, Kenneth Pope, Fadi G. Akar, Caroline H. Roney, Steven A. Niederer, Stanley Nattel, Martyn P. Nash, Richard H. Clayton, Anand N. Ganesan
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Background and Objective: Renewal theory is a statistical approach to model the formation and destruction of phase singularities (PS), which occur at the pivots of spiral waves. A common issue arising during observation of renewal processes is an ins
Externí odkaz:
https://doaj.org/article/664837bf89df46e199ca5af997fc3930
Autor:
Donghai Liu, Andrew Taehun Song, Xiaoyan Qi, Patrick Piet van Vliet, Jiening Xiao, Feng Xiong, Gregor Andelfinger, Stanley Nattel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
A mutation in Shugoshin-1 causes the Chronic Atrial and Intestinal Dysrhythmia (CAID) Syndrome, but the underlying mechanisms are unknown. Here, the authors show that Shugoshin-1 controls cardiac pacemaker activity by interacting with HCN4 to enhance
Externí odkaz:
https://doaj.org/article/d98ddf71fbdb43a688a704b3014cfe3c
Autor:
Szilvia Déri, Teodóra Hartai, László Virág, Norbert Jost, Alain J. Labro, András Varró, István Baczkó, Stanley Nattel, Balázs Ördög
Publikováno v:
Pharmaceuticals, Vol 15, Iss 12, p 1550 (2022)
Long QT syndrome (LQTS) is an inherited cardiac rhythm disorder associated with increased incidence of cardiac arrhythmias and sudden death. LQTS type 5 (LQT5) is caused by dominant mutant variants of KCNE1, a regulatory subunit of the voltage-gated
Externí odkaz:
https://doaj.org/article/64946fa850dd4ea0b59866906f6d2b92
Autor:
Donald M. Bers, Stanley Nattel
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 17 (2021)
Externí odkaz:
https://doaj.org/article/7ad4924a40b34e15bc555b952b276ada
Autor:
Namit Gaur, Xiao-Yan Qi, David Benoist, Olivier Bernus, Ruben Coronel, Stanley Nattel, Edward J Vigmond
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 6, p e1009137 (2021)
The pig is commonly used as an experimental model of human heart disease, including for the study of mechanisms of arrhythmia. However, there exist differences between human and porcine cellular electrophysiology: The pig action potential (AP) has a
Externí odkaz:
https://doaj.org/article/9831a5a1990a4379bc682430a8199d1d