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pro vyhledávání: '"Stanley Misler"'
Autor:
Stanley Misler
Publikováno v:
Advances in Physiology Education. 33:175-186
Stimulus-secretion coupling (SSC) in endocrine cells remains underappreciated as a subject for the study/teaching of general physiology. In the present article, we review key new electrophysiological, electrochemical, and fluorescence optical techniq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db8fb3fad945a1c67b8e373646e2141
https://doi.org/10.1152/advan.90213.2008
https://doi.org/10.1152/advan.90213.2008
Autor:
Adam S. Dickey, Stanley Misler, David M. Pressel, Zhuan Zhou, David W. Barnett, Amélia M. Silva
Publikováno v:
Channels. 3:181-193
Biphasic insulin secretion in response to glucose, consisting of a transient first phase followed by a progressive second phase, is well described in pancreatic islets. Using single canine beta-cells we have compared the time courses of electrical ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49b6f258895ccf16a4e2be3fd27c1e77
https://doi.org/10.4161/chan.3.3.8972
https://doi.org/10.4161/chan.3.3.8972
Publikováno v:
Channels. 3:101-109
In response to depolarizations that open voltage dependent Ca2+ channels single porcine beta-cells display heterogeneous time courses of exocytosis. Some cells display phasic exocytosis that is triggered by individual or short burst of action potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27c3d601f0131e5b757c1b38f374423
https://doi.org/10.4161/chan.3.2.7866
https://doi.org/10.4161/chan.3.2.7866
Autor:
Ricardo Gouveia Rodrigues, Luis M. Rosario, Amélia M. Silva, Rodrigo A. Cunha, Rosa M. Santos, Stanley Misler, Ângelo R. Tomé
Publikováno v:
Pancreas. 36:279-283
Glucose-induced insulin secretion from pancreatic beta cells is modulated by several hormones and transmitters, namely adenosine triphosphate (ATP) via purinergic receptors. Although P2Y receptors are well documented in beta cells, the presence of P2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3edb4b734868993570d36beeab193adf
https://doi.org/10.1097/mpa.0b013e31815a8473
https://doi.org/10.1097/mpa.0b013e31815a8473
Publikováno v:
The Journal of Physiology. 572:379-392
Exposure of pancreatic islets of Langerhans to physiological concentrations of glucose leads to secretion of insulin in an oscillatory pattern. The oscillations in insulin secretion are associated with oscillations in cytosolic Ca2+ concentration ([C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55a8d6282f1f39c82e765a8083f12bf6
https://doi.org/10.1113/jphysiol.2005.101766
https://doi.org/10.1113/jphysiol.2005.101766
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 450:395-404
Studies of stimulus-secretion coupling in human beta-cells have been hampered by poor availability of tissue due to variability of the supply of cadaver pancreati and in the adequacy of enzymatic liberation of islets as well as by the shunting of iso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05a111ca8407f08899fb1eb86a95e6f
https://doi.org/10.1007/s00424-005-1401-y
https://doi.org/10.1007/s00424-005-1401-y
Publikováno v:
The Journal of Physiology. 565:783-799
α-Latrotoxin (α-LT), a potent excitatory neurotoxin, increases spontaneous, as well as action potential-evoked, quantal release at nerve terminals and increases hormone release from excitable endocrine cells. We have investigated the effects of α-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27de64e4580f842ebf7363c8782cbc0a
https://doi.org/10.1113/jphysiol.2005.082586
https://doi.org/10.1113/jphysiol.2005.082586
Autor:
Zhiqiang Han, Kenichi Otani, Graeme I. Bell, James D. Johnson, Stanley Misler, Hong Wu, Honggang Ye, Yukio Horikawa, Yan Zhang, Kenneth S. Polonsky
Publikováno v:
Journal of Biological Chemistry. 279:24794-24802
Cells are programmed to die when critical signaling and metabolic pathways are disrupted. Inhibiting the type 2 ryanodine receptor (RyR2) in human and mouse pancreatic beta-cells markedly increased apoptosis. This mode of programmed cell death was no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b7e59bac2fcfa1ccfb8b956a31ecf85
https://doi.org/10.1074/jbc.m401216200
https://doi.org/10.1074/jbc.m401216200
Publikováno v:
The Journal of Physiology. 509:355-370
1. The whole-cell perforated-patch recording mode was used to record a Ca2+-dependent K+ current (IK(Ca)) in mouse betaTC-3 insulin-secreting cells. 2. Depolarizing voltage steps (to potentials where Ca2+ currents are activated) evoked a slowly activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::171936abae3de4b1c70bbb08328bf5ef
https://doi.org/10.1111/j.1469-7793.1998.355bn.x
https://doi.org/10.1111/j.1469-7793.1998.355bn.x
Autor:
Stanley Misler, Zhuan Zhou
Publikováno v:
Journal of Biological Chemistry. 271:270-277
Serotonin (5-HT) is taken up in insulin granules and co-released with insulin on stimulation of pancreatic islet beta-cells. Based on these observations, we have used microcarbon fiber amperometry to examine secretogogue-induced 5-HT release from rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8169e7edc45bc6c11cfbe6c5b91c6926
https://doi.org/10.1074/jbc.271.1.270
https://doi.org/10.1074/jbc.271.1.270