Zobrazeno 1 - 10
of 414
pro vyhledávání: '"Stanley M. Lemon"'
Autor:
Stanley M. Lemon
Publikováno v:
Proceedings, Vol 50, Iss 1, p 37 (2020)
Hepatoviruses are unusual picornaviruses, distinct genetically and structurally from other members of the Picornaviridae, exclusively hepatotropic, and released from infected cells without lysis in small membranous vesicles resembling exosomes. These
Externí odkaz:
https://doaj.org/article/c07b5fc38e8246038d367eb53f252a41
Autor:
Anshuman Das, Asuka Hirai-Yuki, Olga González-López, Bethany Rhein, Sven Moller-Tank, Rachel Brouillette, Lucinda Hensley, Ichiro Misumi, William Lovell, John M. Cullen, Jason K. Whitmire, Wendy Maury, Stanley M. Lemon
Publikováno v:
mBio, Vol 8, Iss 5 (2017)
ABSTRACT Receptor molecules play key roles in the cellular entry of picornaviruses, and TIM1 (HAVCR1) is widely accepted to be the receptor for hepatitis A virus (HAV), an unusual, hepatotropic human picornavirus. However, its identification as the h
Externí odkaz:
https://doaj.org/article/89b082e0fcce47b0b40828cd8676694f
Autor:
Jonathan K. Mitchell, Bentley R. Midkiff, Benjamin Israelow, Matthew J. Evans, Robert E. Lanford, Christopher M. Walker, Stanley M. Lemon, David R. McGivern
Publikováno v:
mBio, Vol 8, Iss 2 (2017)
ABSTRACT Many DNA tumor viruses promote cellular transformation by inactivating the critically important tumor suppressor protein p53. In contrast, it is not known whether p53 function is disrupted by hepatitis C virus (HCV), a unique, oncogenic RNA
Externí odkaz:
https://doaj.org/article/9c7aab5b79d24bc7ab1c2afe955f3b68
Publikováno v:
mBio, Vol 7, Iss 6 (2016)
ABSTRACT Hepatitis A virus (HAV) is an unusual picornavirus that is released from cells cloaked in host-derived membranes. These quasi-enveloped virions (eHAV) are the only particle type circulating in blood during infection, whereas only nonenvelope
Externí odkaz:
https://doaj.org/article/b7fc86f173fa4f938111b310bbd14f7a
Autor:
Sara R. Selitsky, Timothy A. Dinh, Cynthia L. Toth, C. Lisa Kurtz, Masao Honda, Benjamin R. Struck, Shuichi Kaneko, Kasey C. Vickers, Stanley M. Lemon, Praveen Sethupathy
Publikováno v:
mBio, Vol 6, Iss 6 (2015)
ABSTRACT Chronic hepatitis B (CHB), chronic hepatitis C (CHC), and associated hepatocellular carcinoma (HCC) are characterized by cholesterol imbalance and dyslipidemia; however, the key regulatory drivers of these phenotypes are incompletely underst
Externí odkaz:
https://doaj.org/article/ffbd9c2184134729937448deb9f0325a
Autor:
Takayoshi Shirasaki, Hui Feng, Helen M E Duyvesteyn, William G Fusco, Kevin L McKnight, Ling Xie, Mark Boyce, Sathish Kumar, Rina Barouch-Bentov, Olga González-López, Ryan McNamara, Li Wang, Adriana Hertel-Wulff, Xian Chen, Shirit Einav, Joseph A Duncan, Maryna Kapustina, Elizabeth E Fry, David I Stuart, Stanley M Lemon
Publikováno v:
PLoS Pathogens, Vol 18, Iss 8, p e1010543 (2022)
Although picornaviruses are conventionally considered 'nonenveloped', members of multiple picornaviral genera are released nonlytically from infected cells in extracellular vesicles. The mechanisms underlying this process are poorly understood. Here,
Externí odkaz:
https://doaj.org/article/71fe0a3da16d43cda03ca15add33c19f
A comprehensive survey of the most recent discoveries in this field. Focuses on the antiviral signaling pathways in the host, including specific pattern recognition receptors and how these cellular alarms signal the innate immune response.
Autor:
Moe Matsumoto, Jennifer L Modliszewski, Kotomi Shinozaki, Reona Maezawa, Vincent M Perez, Yuki Ishikawa, Ryosuke Suzuki, Kevin L McKnight, Takahiro Masaki, Asuka Hirai-Yuki, Michinori Kohara, Stanley M Lemon, Sara R Selitsky, Daisuke Yamane
Publikováno v:
Nucleic Acids Research. 51:4451-4466
Interferon regulatory factor 1 (IRF1) is a critical component of cell-intrinsic innate immunity that regulates both constitutive and induced antiviral defenses. Due to its short half-life, IRF1 function is generally considered to be regulated by its
Autor:
Institute of Medicine, Board on Global Health, Forum on Microbial Threats, Alison Mack, Eileen R. Choffnes, P. Frederick Sparling, Margaret A. Hamburg, Stanley M. Lemon
Early detection is essential to the control of emerging, reemerging, and novel infectious diseases, whether naturally occurring or intentionally introduced. Containing the spread of such diseases in a profoundly interconnected world requires active v
Publikováno v:
eLife, Vol 8 (2019)
Many ‘non-enveloped’ viruses, including hepatitis A virus (HAV), are released non-lytically from infected cells as infectious, quasi-enveloped virions cloaked in host membranes. Quasi-enveloped HAV (eHAV) mediates stealthy cell-to-cell spread wit
Externí odkaz:
https://doaj.org/article/5eb0f6f627764d699dc71eb1515f6f1d