Výsledky vyhledávání - "Stanley M. Crain"

Endorphinergic Attenuation of Distress by Concomitantly Enhancing Endogenous Opioid Release and Switching Opioid Receptor Signaling from an Excessively Excitatory to a Normal Inhibitory Mode

Autor: Stanley M. Crain, Steven Crain

Publikováno v: Journal of Behavioral and Brain Science. :497-508

The endogenous opioid system plays a significant role in the modulation of distress in many psychiatric, neurologic, and neurodevelopmental disorders. Many clinical distress symptoms show similarities to the excitatory autonomic withdrawal effects in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::461b18516c806e00dd5b76e5dac96c0f
https://doi.org/10.4236/jbbs.2013.37052

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Emotional and Physical Distress Relief Using a Novel Endorphinergic Formulation

Autor: Steven Crain, Stanley M. Crain, Matthew A. Crain

Publikováno v: Journal of Behavioral and Brain Science. :441-453

While the endogenous opioid system has generally been associated with regulation of pain, it also modulates the experience of distress and may play a central role in many psychiatric and neurodevelopmental disorders. Decades of preclinical research o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11301d28aa191421c0abe8b223a562ec
https://doi.org/10.4236/jbbs.2013.36046

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Low doses of cyclic AMP-phosphodiesterase inhibitors rapidly evoke opioid receptor-mediated thermal hyperalgesia in naïve mice which is converted to prominent analgesia by cotreatment with ultra-low-dose naltrexone

Autor: Stanley M. Crain, Ke-Fei Shen

Publikováno v: Brain Research. 1231:16-24

Systemic (s.c.) injection in naive mice of cyclic AMP-phosphodiesterase (cAMP-PDE) inhibitors, e.g. 3-isobutyl-1-methylxanthine [(IBMX) or caffeine, 10 mg/kg] or the more specific cAMP-PDE inhibitor, rolipram (1 μg/kg), rapidly evokes thermal hypera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928c7ee93db23824e7b2c9541ca9f449
https://doi.org/10.1016/j.brainres.2008.07.015

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Naloxone rapidly evokes endogenous kappa opioid receptor-mediated hyperalgesia in naïve mice pretreated briefly with GM1 ganglioside or in chronic morphine-dependent mice

Autor: Ke-Fei Shen, Stanley M. Crain

Publikováno v: Brain Research. 1167:31-41

Low-dose naloxone-precipitated withdrawal hyperalgesia is a reliable indicator of physical dependence after chronic morphine treatment. A remarkably similar long-lasting (>3-4 h) hyperalgesia is evoked by injection of a low dose of naloxone (10 micro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::790dfa1e1ae06763d37679d7411d62dd
https://doi.org/10.1016/j.brainres.2007.06.058

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Cholera toxin-B subunit blocks excitatory opioid receptor-mediated hyperalgesic effects in mice, thereby unmasking potent opioid analgesia and attenuating opioid tolerance/dependence

Autor: Stanley M. Crain, Ke-Fei Shen

Publikováno v: Brain Research. 919:20-30

In a previous study we demonstrated that injection (i.p.) of low doses of GM1 ganglioside in mice rapidly attenuates morphine's analgesic effects. This result is consonant with our electrophysiologic studies in nociceptive types of dorsal root gangli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3a6f7ec96fc074610ee74253b84ab75
https://doi.org/10.1016/s0006-8993(01)02990-0

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Development of Specific Synaptic Network Functions in Organotypic Central Nervous System (CNS) Cultures: Implications for Transplantation of CNS Neural Cellsin Vivo

Autor: Stanley M. Crain

Publikováno v: Methods. 16:228-238

This article provides a broad overview of the significant roles that morphophysiologic analyses of organotypic cultures of neural tissues explantedin vitro—initiated during the 1950s—have played in stimulating the more recent development of techn

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https://doi.org/10.1006/meth.1998.0681

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Ultra-low doses of naltrexone or etorphine increase morphine's antinociceptive potency and attenuate tolerance/dependence in mice

Autor: Stanley M. Crain, Ke-Fei Shen

Publikováno v: Brain Research. 757:176-190

In previous studies we showed that low (pM) concentrations of naloxone (NLX), naltrexone (NTX) or etorphine selectively antagonize excitatory, but not inhibitory, opioid receptor-mediated functions in nociceptive types of sensory neurons in culture.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e77dcda2ca00daa678e87c2f72a6fd9a
https://doi.org/10.1016/s0006-8993(97)00197-2

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Barium elicits reversal of low-concentration etorphine-induced decrease of potassium conductance in cultures of dissociated dorsal root ganglion neurons

Autor: Stanley M. Crain, Shih-fang Fan

Publikováno v: Brain Research. 754:303-306

Etorphine is an non-selective opioid receptor agonist with very potent analgesic effect. Low concentrations (nM) of most opioid receptor agonists decrease the K+ conductance (gK) in cultures of dissociated mouse dorsal root ganglion neurons regardles

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4730a7e0e5df85735d0e4d4727e6907e
https://doi.org/10.1016/s0006-8993(97)00074-7

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Biphalin, an enkephalin analog with unexpectedly high antinociceptive potency and low dependence liability in vivo, selectively antagonizes excitatory opioid receptor functions of sensory neurons in culture

Autor: Stanley M. Crain, Ke-Fei Shen

Publikováno v: Brain Research. 701:158-166

The mechanism of action of the dimeric enkephalin peptide, biphalin (Tyr-D-Ala-Gly-Phe-NH2)2, which was previously shown to have remarkable high antinociceptive potency and low dependence liability in vivo, has now been studied by electrophysiologic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4725a26ae31ca018adb82454a51bfa97
https://doi.org/10.1016/0006-8993(95)00999-1

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Chronic opioid treatment of neuroblastoma X dorsal root ganglion neuron hybrid F11 cells results in elevated GM1 ganglioside and cyclic adenosine monophosphate levels and onset of naloxone-evoked decreases in membrane K+ currents

Autor: S. F. Fan, Stanley M. Crain, Robert W. Ledeen, Gusheng Wu, Zi Hua Lu

Publikováno v: Journal of Neuroscience Research. 42:493-503

Prolongation of the action potential duration of dorsal root ganglion (DRG) neurons by low (nM) concentrations of opioids occurs through activation of excitatory opioid receptors that are positively coupled via Gs regulatory protein to adenylate cycl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15b6f7414dfe26252caaac8cc4e8ca6
https://doi.org/10.1002/jnr.490420408

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