Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Stanley M Walls"'
1
Akademický článek
Patient-specific genomics and cross-species functional analysis implicate LRP2 in hypoplastic left heart syndrome
Autor: Jeanne L Theis, Georg Vogler, Maria A Missinato, Xing Li, Tanja Nielsen, Xin-Xin I Zeng, Almudena Martinez-Fernandez, Stanley M Walls, Anaïs Kervadec, James N Kezos, Katja Birker, Jared M Evans, Megan M O'Byrne, Zachary C Fogarty, André Terzic, Paul Grossfeld, Karen Ocorr, Timothy J Nelson, Timothy M Olson, Alexandre R Colas, Rolf Bodmer
Publikováno v: eLife, Vol 9 (2020)
Congenital heart diseases (CHDs), including hypoplastic left heart syndrome (HLHS), are genetically complex and poorly understood. Here, a multidisciplinary platform was established to functionally evaluate novel CHD gene candidates, based on whole-g
Externí odkaz: https://doaj.org/article/7b02a3ed48a047c4bd8549ffe623c1c1
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2
Akademický článek
Chronic Voluntary Ethanol Consumption Induces Favorable Ceramide Profiles in Selectively Bred Alcohol-Preferring (P) Rats.
Autor: Jessica Godfrey, Lisa Jeanguenin, Norma Castro, Jeffrey J Olney, Jason Dudley, Joseph Pipkin, Stanley M Walls, Wei Wang, Deron R Herr, Greg L Harris, Susan M Brasser
Publikováno v: PLoS ONE, Vol 10, Iss 9, p e0139012 (2015)
Heavy alcohol consumption has detrimental neurologic effects, inducing widespread neuronal loss in both fetuses and adults. One proposed mechanism of ethanol-induced cell loss with sufficient exposure is an elevation in concentrations of bioactive li
Externí odkaz: https://doaj.org/article/9c35304e766e49549635ede1b70463c7
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3
Akademický článek
The nutrient sensor CRTC and Sarcalumenin/thinman represent an alternate pathway in cardiac hypertrophy
Autor: Cristiana Dondi, Georg Vogler, Anjali Gupta, Stanley M. Walls, Anaïs Kervadec, James Marchant, Michaela R. Romero, Soda Diop, Jason Goode, John B. Thomas, Alex R. Colas, Rolf Bodmer, Marc Montminy, Karen Ocorr
Publikováno v: Cell Reports, Vol 43, Iss 8, Pp 114549- (2024)
Summary: CREB-regulated transcription co-activator (CRTC) is activated by Calcineurin (CaN) to regulate gluconeogenic genes. CaN also has roles in cardiac hypertrophy. Here, we explore a cardiac-autonomous role for CRTC in cardiac hypertrophy. In Dro
Externí odkaz: https://doaj.org/article/c996134180b94600beaae178614fec84
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4
Akademický článek
Survival response to increased ceramide involves metabolic adaptation through novel regulators of glycolysis and lipolysis.
Autor: Niraj K Nirala, Motiur Rahman, Stanley M Walls, Alka Singh, Lihua Julie Zhu, Takeshi Bamba, Eiichiro Fukusaki, Sargur M Srideshikan, Greg L Harris, Y Tony Ip, Rolf Bodmer, Usha R Acharya
Publikováno v: PLoS Genetics, Vol 9, Iss 6, p e1003556 (2013)
The sphingolipid ceramide elicits several stress responses, however, organisms survive despite increased ceramide but how they do so is poorly understood. We demonstrate here that the AKT/FOXO pathway regulates survival in increased ceramide environm
Externí odkaz: https://doaj.org/article/8a5d4e1a1f134ecb8028b312d61fbe4a
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5
Akademický článek
Identification of sphingolipid metabolites that induce obesity via misregulation of appetite, caloric intake and fat storage in Drosophila.
Autor: Stanley M Walls, Steve J Attle, Gregory B Brulte, Marlena L Walls, Kim D Finley, Dale A Chatfield, Deron R Herr, Greg L Harris
Publikováno v: PLoS Genetics, Vol 9, Iss 12, p e1003970 (2013)
Obesity is defined by excessive lipid accumulation. However, the active mechanistic roles that lipids play in its progression are not understood. Accumulation of ceramide, the metabolic hub of sphingolipid metabolism, has been associated with metabol
Externí odkaz: https://doaj.org/article/b13ae1338c014eddb9c88a7abe73a008
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9
Systemic and heart autonomous effects of sphingosine Δ4 desaturase deficiency in lipotoxic cardiac pathophysiology
Autor: Stanley M. Walls, Rolf Bodmer, Greg L. Harris, Dale A. Chatfield, Karen Ocorr
Publikováno v: Disease Models & Mechanisms
article-version (VoR) Version of Record
Disease Models & Mechanisms, Vol 13, Iss 8 (2020)
Lipotoxic cardiomyopathy (LCM) is characterized by cardiac steatosis, including the accumulation of fatty acids, triglycerides and ceramides. Model systems have shown the inhibition of ceramide biosynthesis to antagonize obesity and improve insulin s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5bd5afb97f893b02217022717dfc785
http://europepmc.org/articles/PMC7438009
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10
Prolonged Exposure to Microgravity Reduces Cardiac Contractility and Initiates Remodeling in Drosophila
Autor: Andrew D. McCulloch, Stanley M. Walls, Georg Vogler, Bosco Trinh, Karen Ocorr, Curran Reddy, Rolf Bodmer, Ryan Birse, Peter H.U. Lee, Zhouhui Gan, Sharmila Bhattacharya, Lisa Elmén, Rachel Zardnt, Erika Taylor, Soda Balla Diop, Sreehari Kalvajuri
Publikováno v: SSRN Electronic Journal.
Understanding the effects of microgravity on human organs is crucial to exploration of low earth orbit, the moon, and beyond. Drosophila can be sent to space in large numbers to examine the effects of microgravity on heart structure and function, whi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::418b1d122216c276e08d354762a5fd58
https://doi.org/10.2139/ssrn.3667140
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