Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Stanley L, Hem"'
Autor:
Harm HogenEsch, Indresh K. Srivastava, Yide Sun, Stanley L. Hem, Manmohan Singh, Bethany Hansen, Padma Malyala
Publikováno v:
Journal of Pharmaceutical Sciences. 100:3245-3250
The importance of the strength of antigen adsorption by aluminum-containing adjuvants on immunopotentiation was studied using HIV 1 SF162dV2gp140 (gp140), a potential HIV/AIDS antigen. The strengths of adsorption by aluminum hydroxide (AH) adjuvant a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d819a0469f995ab32b302a504d69ebb
https://doi.org/10.1002/jps.22555
https://doi.org/10.1002/jps.22555
Publikováno v:
Vaccine. 25:6618-6624
Adsorption of the antigen to an aluminum-containing adjuvant is considered an important aspect of vaccine formulation. Adsorption is described by two parameters: the maximum amount that can be adsorbed as a monolayer, which is characterized by the ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f521b8cc25dfeea23396f1cacbd967fe
https://doi.org/10.1016/j.vaccine.2007.06.049
https://doi.org/10.1016/j.vaccine.2007.06.049
Publikováno v:
Vaccine. 25:4575-4585
Aluminum-containing adjuvants are widely used in licensed human and veterinary vaccines. However, the mechanism by which these adjuvants enhance the immune response and predominantly stimulate a T(H)2 humoral immune response is not well understood. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816e50c14a95ee34b38d06a9a199b56f
https://doi.org/10.1016/j.vaccine.2007.03.045
https://doi.org/10.1016/j.vaccine.2007.03.045
Publikováno v:
Vaccine. 25:825-833
The degree of antigen adsorption by aluminum-containing adjuvants is considered an important characteristic of vaccines that is related to immunopotentiation by the adjuvant. This study examined immunopotentiation by aluminum phosphate adjuvant in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca14e0f0a9f44c53f4c8d6eafe672f0b
https://doi.org/10.1016/j.vaccine.2006.09.039
https://doi.org/10.1016/j.vaccine.2006.09.039
Autor:
Stanley L. Hem, Garry L. Morefield, Dongping Jiang, Ilia Z. Romero-Mendez, Robert L. Geahlen, Harm HogenEsch
Publikováno v:
Vaccine. 23:1502-1506
The phosphate content of commercial ovalbumin was increased from 1.8 to 3.2 mol PO(4)/mol ovalbumin by conjugation of phosphoserine and reduced to 1.2 or 0.14 mol PO(4)/mol ovalbumin by treatment with potato acid phosphatase. The four ovalbumin sampl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::556391e664e9fbaee57e15df0d5774eb
https://doi.org/10.1016/j.vaccine.2004.08.048
https://doi.org/10.1016/j.vaccine.2004.08.048
Autor:
J. Paul Robinson, Stanley L. Hem, Garry L. Morefield, Dongping Jiang, Harm HogenEsch, Anna Sokolovska
Publikováno v:
Vaccine. 23:1588-1595
An important step in the induction of an immune response to vaccines is the internalization of antigens by antigen presenting cells, such as dendritic cells (DCs). Many current vaccines are formulated with antigens adsorbed to an aluminum-containing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf15b18b7d4ae6f29e4196c5f16f7b3
https://doi.org/10.1016/j.vaccine.2004.07.050
https://doi.org/10.1016/j.vaccine.2004.07.050
Publikováno v:
Vaccine. 23:693-698
Calcium phosphate adjuvant is a commercially available vaccine adjuvant that potentiates the immune response to antigens. Although its name suggests that it is Ca 3 (PO 4 ) 2 , X-ray diffraction, FTIR spectroscopy, thermal analysis and the Ca/P molar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf8794b0a9b7c772d910a5f727e3e38
https://doi.org/10.1016/j.vaccine.2004.06.029
https://doi.org/10.1016/j.vaccine.2004.06.029
Publikováno v:
Vaccine. 22:1172-1176
The rate of acid-catalyzed hydrolysis of glucose-1-phosphate (G1P) when adsorbed to aluminum hydroxide adjuvant was significantly slower than the rate of hydrolysis of a solution of G1P at the same pH. It was concluded that the positively charged alu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cdd8fe98ea60d11a05675ae1cc16027
https://doi.org/10.1016/j.vaccine.2003.09.037
https://doi.org/10.1016/j.vaccine.2003.09.037
Publikováno v:
Vaccine. 21:1219-1223
The effect of the degree of adsorption after exposure to interstitial fluid on the immune response in mice to model vaccines containing ovalbumin, alpha casein or dephosphorylated alpha casein adsorbed to aluminum hydroxide adjuvant was studied. Oval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1839e6fed4e61992a7fbf70e3240fd3a
https://doi.org/10.1016/s0264-410x(02)00556-x
https://doi.org/10.1016/s0264-410x(02)00556-x
Publikováno v:
Pharmaceutical Development and Technology. 8:349-356
Five aluminum phosphate adjuvants having P/Al molar ratios ranging from 0.74 to 0.26 were prepared. The adjuvants were characterized by both protein adsorptive capacity and rate of acid neutralization at pH 2.25, 25 degrees C. The protein adsorptive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bbc70145b2cd1963a30a0af739701e3
https://doi.org/10.1081/pdt-120024688
https://doi.org/10.1081/pdt-120024688