Zobrazeno 1 - 10
of 488
pro vyhledávání: '"Stanley H. Appel"'
Autor:
Jason R. Thonhoff, David R. Beers, Weihua Zhao, Alireza Faridar, Aaron Thome, Shixiang Wen, Aijun Zhang, Jinghong Wang, Stanley H. Appel
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
ObjectiveTo determine whether a combination therapy with abatacept (CTLA4-Ig) and interleukin-2 (IL-2) is safe and suppresses markers of oxidative stress, inflammation, and degeneration in ALS.MethodsIn this open-label study, four participants with A
Externí odkaz:
https://doaj.org/article/23b3a503a45b412f8431ba1083024eb8
Autor:
Alireza Faridar, Abdulmunaim M. Eid, Aaron D. Thome, Weihua Zhao, David R. Beers, Maria B. Pascual, Mohammad O. Nakawah, Gustavo C. Roman, Charles S. Davis, Michael Grundman, Joseph C. Masdeu, Stanley H. Appel
Publikováno v:
Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-4 (2023)
Trial registration ClinicalTrials.gov Identifier: NCT05821153, Registered April 20 2023, Retrospectively registered, https://classic.clinicaltrials.gov/ct2/show/NCT05821153
Externí odkaz:
https://doaj.org/article/e8a0ebe6290e4359b7e72393eaf523ef
Autor:
Alireza Faridar, Matthew Vasquez, Aaron D. Thome, Zheng Yin, Hui Xuan, Jing Hong Wang, Shixiang Wen, Xuping Li, Jason R. Thonhoff, Weihua Zhao, Hong Zhao, David R. Beers, Stephen T. C. Wong, Joseph C. Masdeu, Stanley H. Appel
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-13 (2022)
Abstract Background Regulatory T cells (Tregs) play a neuroprotective role by suppressing microglia and macrophage-mediated inflammation and modulating adaptive immune reactions. We previously documented that Treg immunomodulatory mechanisms are comp
Externí odkaz:
https://doaj.org/article/52b183fb078941b9b217ebdf26d36db7
Autor:
Aaron D. Thome, Farah Atassi, Jinghong Wang, Alireza Faridar, Weihua Zhao, Jason R. Thonhoff, David R. Beers, Eugene C. Lai, Stanley H. Appel
Publikováno v:
npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-12 (2021)
Abstract Inflammation is a pathological hallmark of Parkinson’s disease (PD). Chronic pro-inflammatory responses contribute to the loss of neurons in the neurodegenerative process. The present study was undertaken to define the peripheral innate an
Externí odkaz:
https://doaj.org/article/31fbf101a5d54be486190d6c220e76d4
Autor:
Aaron D. Thome, Jason R. Thonhoff, Weihua Zhao, Alireza Faridar, Jinghong Wang, David R. Beers, Stanley H. Appel
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Extracellular vehicles (EVs) are efficient biomarkers of disease and participate in disease pathogenesis; however, their use as clinical therapies to modify disease outcomes remains to be determined. Cell-based immune therapies, including regulatory
Externí odkaz:
https://doaj.org/article/d4950a1a2da241859872c70b9fd4dbf0
Autor:
Aaron D. Thome, Alireza Faridar, David R. Beers, Jason R. Thonhoff, Weihua Zhao, Shixiang Wen, Belen Pascual, Joseph C. Masdeu, Stanley H. Appel
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-11 (2018)
Abstract Background Neuroinflammation is a hallmark of neurodegenerative disease and a significant component of the pathology of Alzheimer’s disease (AD). Patients present with extensive microgliosis along with elevated pro-inflammatory signaling i
Externí odkaz:
https://doaj.org/article/bd79f6c8e3194aba94dfcf283d6034b3
Autor:
David R. Beers, Weihua Zhao, Jason R. Thonhoff, Alireza Faridar, Aaron D. Thome, Shixiang Wen, Jinghong Wang, Stanley H. Appel
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 12, Iss , Pp 100209- (2021)
Amyotrophic lateral sclerosis (ALS) is a multifactorial, multisystem pro-inflammatory neuromuscular disorder. Activation of programmed cell death-1 (PD-1), and its ligands, programmed cell death-ligand 1 and 2 (PD-L1/L2), leads to immune suppression.
Externí odkaz:
https://doaj.org/article/02c2c05243564fc2af7fc3db2353d077
Autor:
Weihua Zhao, David R. Beers, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Jinghong Wang, Shixiang Wen, Loren Ornelas, Dhruv Sareen, Helen S. Goodridge, Clive N. Svendsen, Stanley H. Appel
Publikováno v:
iScience, Vol 23, Iss 6, Pp 101192- (2020)
Summary: Amyotrophic lateral sclerosis (ALS) is a disorder with immune alterations that augment disease severity. M2 macrophages benefit diabetic and nephrotic mice by suppressing the pro-inflammatory state. However, neither have M2 cells been invest
Externí odkaz:
https://doaj.org/article/67b09fdc1b1d4b14a65212fba39aef58
Autor:
Matthew D. Cykowski, Suzanne Z. Powell, Joan W. Appel, Anithachristy S. Arumanayagam, Andreana L. Rivera, Stanley H. Appel
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-15 (2018)
Abstract Muscle atrophy with weakness is a core feature of amyotrophic lateral sclerosis (ALS) that has long been attributed to motor neuron loss alone. However, several studies in ALS patients, and more so in animal models, have challenged this assu
Externí odkaz:
https://doaj.org/article/51fcef74f62649fa96612042a6903f79
Publikováno v:
Neurobiology of Disease, Vol 48, Iss 3, Pp 418-428 (2012)
Activated microglia and infiltrating lymphocytes are neuropathological hallmarks of amyotrophic lateral sclerosis (ALS), a fatal motoneuron disease. Although both cell types play pivotal roles in the ALS pathogenic process, the interactions between m
Externí odkaz:
https://doaj.org/article/77287139bcb74c41a4aa8dbbe20091b7