Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Stanley G. Rane"'
Publikováno v:
Journal of Neuroscience Research. 74:23-36
Modulation of calcium channel expression and function in the context of neurotrophin induced neuronal differentiation remains incompletely understood at a mechanistic level. We addressed this issue in the PC12 model neuronal system using patch clamp
Publikováno v:
Molecular Pharmacology. 61:936-944
KP4 is a virally encoded fungal toxin secreted by the P4 killer strain of Ustilago maydis. Previous studies demonstrated that this toxin inhibits growth of the target fungal cells by blocking calcium uptake rather than forming channels, as had been s
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 282:E184-E196
Patch clamp experiments were conducted to study the effects of basal lamina (basement membrane) of chicken ovarian follicle on membrane Ca2+currents in differentiated chicken granulosa cells in a homologous system. The whole cell patch clamp techniqu
Publikováno v:
American Journal of Physiology-Cell Physiology. 282:C34-C48
Patch-clamp experiments were conducted to study the effects of basal lamina (basement membrane) of preovulatory chicken ovarian follicle on membrane currents in differentiated chicken granulosa cells in a homologous system. The membrane capacitance (
Autor:
Stanley G. Rane, T L Peña
Publikováno v:
Journal of Membrane Biology. 172:249-257
The fibroblast intermediate conductance, calcium-activated potassium channel (FIK) is proposed here as a functional prototype for other IK channels which to date have undefined physiologic actions. FIK pharmacology in the 10T1/2-MRF4 myogenic fibrobl
Autor:
Stanley G. Rane
Publikováno v:
Perspectives in Drug Discovery and Design. :295-311
Potassium channels, especially small and intermediate conductance KCa channels, have important roles in controlling cell proliferation and differentiation. Thus far regulation of these channels is reported to be primarily at the level of expression,
Publikováno v:
Journal of Neuroscience Research. 47:16-26
In response to nerve growth factor (NGF) or basic fibroblast growth factor (bFGF) receptor activated Ras/extracellular signal-regulated kinase (ERK) signaling, PC12 cells undergo a prototypical neuronal differentiation program, characterized by neuri
Autor:
Jonathan D. Pollock, Stanley G. Rane
Publikováno v:
Journal of Biological Chemistry. 271:8008-8014
Nerve growth factor and basic fibroblast growth factor bind to and activate receptor tyrosine kinases, causing sequential signaling via the p21ras/extracellular signal-regulated kinase pathway. The necessity and sufficiency of this signaling pathway
Autor:
Stanley G. Rane, Yi Huang
Publikováno v:
Journal of Biological Chemistry. 269:31183-31189
p21ras plays a critical role in cell growth, differentiation, and oncogenic transformation. However, the final physiological effectors of p21ras-mediated signal transduction remain to be determined. We have used patch clamp electrophysiology, pharmac
Autor:
Wayne A. Twitchell, Stanley G. Rane
Publikováno v:
Neuron. 10:701-709
Opioid peptides are abundantly expressed in the adrenal medulla, and there is evidence that they may be released presynaptically or as medullary paracrine agents. To assess the physiological relevance of these observations, we investigated opioid eff