Zobrazeno 1 - 10
of 209
pro vyhledávání: '"Stanley G. Nathenson"'
Autor:
Eszter Lázár-Molnár, Lisa Scandiuzzi, Indranil Basu, Thomas Quinn, Eliezer Sylvestre, Edith Palmieri, Udupi A. Ramagopal, Stanley G. Nathenson, Chandan Guha, Steven C. Almo
Publikováno v:
EBioMedicine, Vol 17, Iss C, Pp 30-44 (2017)
Programmed Cell Death-1 (PD-1) is an inhibitory immune receptor, which plays critical roles in T cell co-inhibition and exhaustion upon binding to its ligands PD-L1 and PD-L2. We report the crystal structure of the human PD-1 ectodomain and the mappi
Externí odkaz:
https://doaj.org/article/3c7eab1bc1f246abbbcc754b857cc30a
Autor:
Lisa Scandiuzzi, Kaya Ghosh, Kimberly A. Hofmeyer, Yael M. Abadi, Eszter Lázár-Molnár, Elaine Y. Lin, Qiang Liu, Hyungjun Jeon, Steven C. Almo, Lieping Chen, Stanley G. Nathenson, Xingxing Zang
Publikováno v:
Cell Reports, Vol 6, Iss 4, Pp 625-632 (2014)
B7-H1 (PD-L1) on immune cells plays an important role in T cell coinhibition by binding its receptor PD-1. Here, we show that both human and mouse intestinal epithelium express B7-H1 and that B7-H1-deficient mice are highly susceptible to dextran sod
Externí odkaz:
https://doaj.org/article/e24dddc1243d4eea8c4616fd4e930c05
Autor:
Thomas J. Quinn, Eszter Lazar-Molnar, Chandan Guha, Indranil Basu, Steven C. Almo, Edith Palmieri, Eliezer Sylvestre, Stanley G. Nathenson, Udupi A. Ramagopal, Lisa Scandiuzzi
Publikováno v:
EBioMedicine, Vol 17, Iss C, Pp 30-44 (2017)
EBioMedicine
EBioMedicine
Programmed Cell Death-1 (PD-1) is an inhibitory immune receptor, which plays critical roles in T cell co-inhibition and exhaustion upon binding to its ligands PD-L1 and PD-L2. We report the crystal structure of the human PD-1 ectodomain and the mappi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73522bca8d582a148e97b65560d02861
http://www.sciencedirect.com/science/article/pii/S2352396417300622
http://www.sciencedirect.com/science/article/pii/S2352396417300622
Autor:
John E. Coligan, T H Hansen, Stanley G. Nathenson, J. Scott Cairns, William E. Biddison, Gertrude M. Pfaffenbach, Marie Rose van Schravendijk, Fritz H. Bach, Richard A. Zeff
Publikováno v:
Paradoxes in Immunology ISBN: 9780429286353
Paradoxes in Immunology
Paradoxes in Immunology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::763321d37d0f349100158846a6ed590f
https://doi.org/10.1201/9780429286353-25
https://doi.org/10.1201/9780429286353-25
Autor:
Stanley G. Nathenson, Chenyang Zhan, Weifeng Liu, Jeffrey B. Bonanno, Steven C. Almo, P. Rajesh Kumar, Huiyong Cheng
Publikováno v:
Structure. 22:1252-1262
LIGHT initiates intracellular signaling via engagement of the two TNF receptors, HVEM and LTβR. In humans, LIGHT is neutralized by DcR3, a unique soluble member of the TNFR superfamily, which tightly binds LIGHT and inhibits its interactions with HV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4726aa095e16622b268c5d4674c2d9f2
https://doi.org/10.1016/j.str.2014.06.013
https://doi.org/10.1016/j.str.2014.06.013
Autor:
Lieping Chen, Lisa Scandiuzzi, Eszter Lazar-Molnar, Elaine Y. Lin, Xingxing Zang, Yael M. Abadi, Stanley G. Nathenson, Qiang Liu, Kimberly A. Hofmeyer, Steven C. Almo, Kaya Ghosh, Hyung Jun Jeon
Publikováno v:
Cell Reports, Vol 6, Iss 4, Pp 625-632 (2014)
SummaryB7-H1 (PD-L1) on immune cells plays an important role in T cell coinhibition by binding its receptor PD-1. Here, we show that both human and mouse intestinal epithelium express B7-H1 and that B7-H1-deficient mice are highly susceptible to dext
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e21527cc99a2b41c3e15669b2e9c0982
Autor:
Stanley G. Nathenson, Vladimir N. Malashkevich, Udupi A. Ramagopal, Jeffrey Shabanowitz, Rodolfo J. Chaparro, Daniel R. Brims, Irene Jarchum, Steven C. Almo, Leann M. Mikesh, Edith Palmieri, Masakazu Hattori, Teresa P. DiLorenzo, Torben Lund, Jie Qian, Donald F. Hunt
Publikováno v:
International Immunology. 22:191-203
Type 1 diabetes (T1D) is an autoimmune disease characterized by T cell-mediated destruction of insulin-producing pancreatic beta cells. In both humans and the non-obese diabetic (NOD) mouse model of T1D, class II MHC alleles are the primary determina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b271644f8e5419b6f43354eeacb561a
https://doi.org/10.1093/intimm/dxp127
https://doi.org/10.1093/intimm/dxp127
Autor:
Kausik Chattopadhyay, Chenyang Zhan, Udupi A. Ramagopal, Eszter Lazar-Molnar, Vladimir Vigdorovich, Jeffrey B. Bonanno, Qingrong Yan, Rotem Rubinstein, Steven C. Almo, Stanley G. Nathenson
Publikováno v:
Immunological Reviews. 229:356-386
Costimulatory receptors and ligands trigger the signaling pathways that are responsible for modulating the strength, course, and duration of an immune response. High-resolution structures have provided invaluable mechanistic insights by defining the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f81e2bdcb567a957b7d92d4f39d67b
https://doi.org/10.1111/j.1600-065x.2009.00778.x
https://doi.org/10.1111/j.1600-065x.2009.00778.x
Autor:
Steven C. Almo, Erhu Cao, Qingrong Yan, Stanley G. Nathenson, Eszter Lazar-Molnar, Udupi A. Ramagopal
Publikováno v:
Proceedings of the National Academy of Sciences. 105:10483-10488
Programmed death-1 (PD-1) is a member of the CD28/B7 superfamily that delivers negative signals upon interaction with its two ligands, PD-L1 or PD-L2. The high-resolution crystal structure of the complex formed by the complete ectodomains of murine P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53df71d6ededde4e79b099d9cbb6ef17
https://doi.org/10.1073/pnas.0804453105
https://doi.org/10.1073/pnas.0804453105
Autor:
Eszter Lazar-Molnar, Stanley G. Nathenson, Gordon J. Freeman, Joshua D. Nosanchuk, Steven C. Almo, Attila Gácser
Publikováno v:
Proceedings of the National Academy of Sciences. 105:2658-2663
The PD-1 costimulatory receptor inhibits T cell receptor signaling upon interacting with its ligands PD-L1 and PD-L2. The PD-1/PD-L pathway is critical in maintaining self-tolerance. In this study, we examined the role of PD-1 in a mouse model of acu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::249c5b39819efa3a970097f924f3babd
https://doi.org/10.1073/pnas.0711918105
https://doi.org/10.1073/pnas.0711918105