Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Stanley G Leung"'
Autor:
Jacob Pfeil, Lauren M Sanders, Ioannis Anastopoulos, A Geoffrey Lyle, Alana S Weinstein, Yuanqing Xue, Andrew Blair, Holly C Beale, Alex Lee, Stanley G Leung, Phuong T Dinh, Avanthi Tayi Shah, Marcus R Breese, W Patrick Devine, Isabel Bjork, Sofie R Salama, E Alejandro Sweet-Cordero, David Haussler, Olena Morozova Vaske
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 4, p e1007753 (2020)
Precision oncology has primarily relied on coding mutations as biomarkers of response to therapies. While transcriptome analysis can provide valuable information, incorporation into workflows has been difficult. For example, the relative rather than
Externí odkaz:
https://doaj.org/article/6b18e66d017444afb3146ec81d8a8f6f
Autor:
Kaja Kostyrko, Marta Román, Alex G. Lee, David R. Simpson, Phuong T. Dinh, Stanley G. Leung, Kieren D. Marini, Marcus R. Kelly, Joshua Broyde, Andrea Califano, Peter K. Jackson, E. Alejandro Sweet-Cordero
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract KRAS is a frequent driver in lung cancer. To identify KRAS-specific vulnerabilities in lung cancer, we performed RNAi screens in primary spheroids derived from a Kras mutant mouse lung cancer model and discovered an epigenetic regulator Ubiq
Externí odkaz:
https://doaj.org/article/bfd9eceda508466c9e02d6a2c91e89f7
Autor:
Savannah S. Shumock, William C. Temple, Amanda Marinoff, Kathryn Aaronson, Erica Southworth, Simayijiang Xirenayi, Alex G. Lee, Stanley G. Leung, E. Alejandro Sweet‐Cordero, Michelle Hermiston, Christine Higham, Elliot Stieglitz
Publikováno v:
Cancer Reports, Vol 6, Iss 12, Pp n/a-n/a (2023)
Abstract Background The development of tyrosine kinase inhibitors (TKIs) has significantly improved survival rates among patients with Philadelphia chromosome (Ph+) B cell acute lymphoblastic leukemia (B‐ALL). Ph‐like B‐ALL patients lack the BC
Externí odkaz:
https://doaj.org/article/b939915b6792494fb624d0253983d87f
Autor:
Courtney R. Schott, Amanda L. Koehne, Leanne C. Sayles, Elizabeth P. Young, Cuyler Luck, Katharine Yu, Alex G. Lee, Marcus R. Breese, Stanley G. Leung, Hang Xu, Avanthi Tayi Shah, Heng-Yi Liu, Aviv Spillinger, Inge H. Behroozfard, Kieren D. Marini, Phuong T. Dinh, María V. Pons Ventura, Emma N. Vanderboon, Florette K. Hazard, Soo-Jin Cho, Raffi S. Avedian, David G. Mohler, Melissa Zimel, Rosanna Wustrack, Christina Curtis, Marina Sirota, E. Alejandro Sweet-Cordero
Publikováno v:
bioRxiv
Models to study metastatic disease in rare cancers are needed to advance preclinical therapeutics and to gain insight into disease biology, especially for highly aggressive cancers with a propensity for metastatic spread. Osteosarcoma is a rare cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0ee0ac364e1000526423f6f55b43f81
https://doi.org/10.1101/2023.01.19.524562
https://doi.org/10.1101/2023.01.19.524562
Autor:
Henry J. Martell, Avanthi T. Shah, Alex G. Lee, Bogdan Tanasa, Stanley G. Leung, Aviv Spillinger, Heng-Yi Liu, Inge Behroozfard, Phuong Dinh, María V. Pons Ventura, Florette K. Hazard, Arun Rangaswami, Sheri L. Spunt, Norman J. Lacayo, Tabitha Cooney, Jennifer G. Michlitsch, Anurag K. Agrawal, Marcus R. Breese, Alejandro Sweet-Cordero
Publikováno v:
Cancer Research. 83:1509-1509
For many pediatric cancer patients, commonly used gene-panel sequencing tests yield few actionable results, partly due to the complex genomic alterations present. We hypothesized that an unbiased approach, combining whole-genome (WGS) and RNA sequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27b898ddfe3bc343e773f0ae5f6196c3
https://doi.org/10.1158/1538-7445.am2023-1509
https://doi.org/10.1158/1538-7445.am2023-1509
Autor:
Andrew S. Clugston, Megan Ostrowski, Coco Wu, Leanne Sayles, Stanley G. Leung, Vijay Ramani, E. Alejandro Sweet-Cordero, Marcus R. Breese
Publikováno v:
Cancer Research. 83:214-214
We have leveraged long-read and spatial sequencing modalities to identify patient-specific oncogenic alterations for treatment of pediatric osteosarcomas. Osteosarcoma (OS) is the most common primary bone malignancy in children and young adults, with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dc2faed665200d18d19116842ad15ef
https://doi.org/10.1158/1538-7445.am2023-214
https://doi.org/10.1158/1538-7445.am2023-214
Autor:
Stephen M. Smith, Alex G. Lee, Schuyler Tong, Stanley G. Leung, Henry Hongo, Jose M. Rivera, E. Alejandro Sweet-Cordero, Jennifer Michlitsch, Elliot Stieglitz
Publikováno v:
Cold Spring Harbor molecular case studies, vol 8, iss 5
Infants diagnosed with acute myeloid leukemia (AML) frequently harbor cytogenetically cryptic fusions involving KMT2A, NUP98, or GLIS2. Those with AML driven specifically by CBFA2T3::GLIS2 fusions have a dismal prognosis and are currently risk-strati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e83cd7a6316322966737e117511aae07
https://pubmed.ncbi.nlm.nih.gov/35927023
https://pubmed.ncbi.nlm.nih.gov/35927023
Autor:
Anya Levinson, Jessica Van Ziffle, M Dwight Chen, Jacob Pfeil, Inge Behroozfard, E. Alejandro Sweet-Cordero, Charles Zaloudek, Avanthi Tayi Shah, Stanley G. Leung, Elliot Stieglitz, Arjun A. Rao, Benjamin Laguna, Nicholas R. Ladwig, Henry J Martell, Sofie R. Salama, Alex G. Lee, Marcus R. Breese, Lee-may Chen
Publikováno v:
JCO Precision Oncology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fda6e5cb23a53fecc0fc172016633116
https://doi.org/10.1200/po.20.00132
https://doi.org/10.1200/po.20.00132
Autor:
Stanley G. Leung, Avanthi Tayi Shah, Ash A. Alizadeh, Heike E. Daldrup-Link, Inge Behroozfard, Allison Pribnow, Jacob J. Chabon, Florette K. Hazard, David M. Kurtz, Tej D. Azad, Marcus R. Breese, Norman J. Lacayo, Soo-Jin Cho, E. Alejandro Sweet-Cordero, Sheri L. Spunt, Maximilian Diehn, Kieuhoa T. Vo, Frederick M. Wittber, Arun Rangaswami, Heng-Yi Liu, Aviv Spillinger, Krystal Straessler, Emily G. Hamilton
Publikováno v:
Molecular cancer therapeutics, vol 20, iss 10
Mol Cancer Ther
Mol Cancer Ther
Most circulating tumor DNA (ctDNA) assays are designed to detect recurrent mutations. Pediatric sarcomas share few recurrent mutations but rather are characterized by translocations and copy-number changes. We applied Cancer Personalized Profiling by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb53f86840895e7d172afc93a12b111
https://escholarship.org/uc/item/4zr836sf
https://escholarship.org/uc/item/4zr836sf
Autor:
Christopher C. Dvorak, Elliot Stieglitz, Inge Behroozfard, Stanley G. Leung, Julia Chu, Maria Maruffi, Alex G. Lee, E. Alejandro Sweet-Cordero, Marcus R. Breese, Elizabeth P Young, Astrid Behnert
Publikováno v:
J Pediatr Hematol Oncol
Journal of pediatric hematology/oncology, vol 43, iss 6
Journal of pediatric hematology/oncology, vol 43, iss 6
Overlapping myelodysplastic/myeloproliferative neoplasms (MDS/MPN) are clonal hematopoietic disorders with features of myelodysplasia and myeloproliferation. The only well-characterized MDS/MPN in children is juvenile myelomonocytic leukemia, an aggr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3799a25bb6ebdf3c6830498f817b9b08
https://europepmc.org/articles/PMC7889745/
https://europepmc.org/articles/PMC7889745/