Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Stanley E. D'Souza"'
Autor:
James McCracken, Oleg A. Barski, Abhinav Agarwal, Stanley E. D'Souza, Srinivas D Sithu, Nalinie S. Wickramasinghe, Michael L. Merchant, Dale A. Schuschke, Sanjay K. Srivastava, Susan M. Dougherty, Aruni Bhatnagar, Petra Haberzettl, Timothy E. O'Toole, Bradford G. Hill, Sharon A. Gordon, Elena Vladykovskaya
Publikováno v:
Journal of Biological Chemistry. 287:11398-11409
Lipid peroxidation products, such as 4-hydroxy-trans-2-nonenal (HNE), cause endothelial activation, and they increase the adhesion of the endothelium to circulating leukocytes. Nevertheless, the mechanisms underlying these effects remain unclear. We
Autor:
Stanley E. D'Souza, Maqsood A. Siddiqui, David Hoetker, Daniel J. Conklin, Elena Vladykovskaya, Sanjay K. Srivastava, Aruni Bhatnagar, Srinivas D Sithu, Petra Haberzettl
Publikováno v:
Atherosclerosis. 215:301-308
Acrolein is a dietary aldehyde that is present in high concentrations in alcoholic beverages and foods including cheese, donuts and coffee. It is also abundant in tobacco smoke, automobile exhaust and industrial waste and is generated in vivo during
Autor:
Elena Vladykovskaya, Petra Haberzettl, Nalinie S. Wickramasinghe, Srinivas D Sithu, Sanjay K. Srivastava, Millicent Winner, Abhinav Agarwal, Stanley E. D'Souza
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 35
Epidemiological and animal studies suggest that exposure to arsenic contaminated water exacerbates atherosclerosis. However, the mechanisms by which arsenic exerts its atherogenic effects are not known. We observed that chronic (1 μM; 4 days) or acu
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 288:H1257-H1264
Elevated fibrinogen (Fg) concentration in blood is a high risk factor for many cardiovascular diseases. We hypothesize that Fg and its early degradation product, fragment D, may result in arterial constriction by binding endothelial intercellular adh
Autor:
William R. English, Stanley E. D'Souza, Nina L. Tsakadze, Utpal Sen, Zhendong Zhao, Srinivas D Sithu
Publikováno v:
American Journal of Physiology-Cell Physiology. 287:C55-C63
ICAM-1, a membrane-bound receptor, is released as soluble ICAM-1 in inflammatory diseases. To delineate mechanisms regulating ICAM-1 cleavage, studies were performed in endothelial cells (EC), human embryonic kidney (HEK)-293 cells transfected with w
Autor:
Ayotunde S.O Adeagbo, Sanjay K. Srivastava, Nina L. Tsakadze, Aruni Bhatnagar, Sunday O. Awe, Stanley E. D'Souza
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 285:H727-H734
Acrolein is a highly reactive aldehyde pollutant and an endogenous product of lipid peroxidation. Increased generation of, or exposures to, acrolein incites pulmonary and vascular injury. The effects of acrolein on the vasomotor responses of rat aort
Publikováno v:
Vascular Pharmacology. 40:51-57
tert-Butyl hydroperoxide (t-BOOH), a membrane permeant oxidant, elicits enhanced vasoconstriction of perfused kidney and mesenteric arterial beds isolated from DOCA-salt-induced hypertensive rats. We hypothesize that enhanced vasoconstriction to t-BO
Publikováno v:
Trends in Cardiovascular Medicine. 12:101-108
The binding of plasma protein fibrinogen (Fg) to intercellular adhesion molecule-1 (ICAM-1) on endothelial cells mediates the attachment of leukocytes and platelets that may result in vascular occlusion. Fg:ICAM-1 interactions elicit an array of effe
Autor:
Elzbieta Pluskota, Stanley E. D'Souza
Publikováno v:
European Journal of Biochemistry. 267:4693-4704
We tested hypothesis that the interaction of fibrinogen (Fg) with intercellular adhesion molecule 1 (ICAM-1) mediates cellular adhesion and cell proliferation. Our results demonstrate that Fg : ICAM-1 ligation mediates endothelial cell survival and h
Publikováno v:
Thrombosis and Haemostasis. 80:726-734
IntroductionA defining characteristic of vascular cells is their adhesive status. The predominant cells of the blood vessel, endothelial cells (EC) and smooth muscle cells (SMC), are normally adherent but can be induced to migrate in response to vasc