Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Stanley C. Rall"'
Publikováno v:
Journal of Lipid Research, Vol 40, Iss 11, Pp 1933-1949 (1999)
Type III hyperlipoproteinemia (HLP) is a genetic disorder characterized by accumulation of remnant lipoproteins in the plasma and development of premature atherosclerosis. Although receptor binding-defective forms of apolipoprotein (apo) E are the co
Externí odkaz:
https://doaj.org/article/a3fb3d834e794e398486527d191caa1f
Autor:
Zhong-Sheng Ji, Robert W. Mahley, Yadong Huang, John M. Taylor, Walter J. Brecht, Stanley C. Rall
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 19:2952-2959
Abstract —The differential effects of overexpression of human apolipoprotein (apo) E3 on plasma cholesterol and triglyceride metabolism were investigated in transgenic rabbits expressing low (20 mg/dL) levels of apoE3. Cholesterol levels increased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1309b8c1429f17a9fd886cb559f04d5
https://doi.org/10.1161/01.atv.19.12.2952
https://doi.org/10.1161/01.atv.19.12.2952
Publikováno v:
Journal of Lipid Research, Vol 40, Iss 11, Pp 1933-1949 (1999)
Type III hyperlipoproteinemia (HLP) is a genetic disorder characterized by accumulation of remnant lipoproteins in the plasma and development of premature atherosclerosis. Although receptor binding-defective forms of apolipoprotein (apo) E are the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e53883f1d536c4fd6f35ed10186611
https://doi.org/10.1016/s0022-2275(20)32417-2
https://doi.org/10.1016/s0022-2275(20)32417-2
Publikováno v:
Journal of Biological Chemistry. 272:22685-22694
Transgenic rabbits were produced that expressed high plasma levels (30–70 mg/dl) of human apolipoprotein (apo) E2(Cys-158), an apoE variant associated with the human genetic disorder type III hyperlipoproteinemia (HLP). Male transgenic rabbits fed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e06b8a5dd95723aee8ecd4a0883fef2
https://doi.org/10.1074/jbc.272.36.22685
https://doi.org/10.1074/jbc.272.36.22685
Publikováno v:
Journal of Biological Chemistry. 271:29146-29151
Transgenic mice were produced that expressed different plasma levels (3-60 mg/dl) of human apolipoprotein (apo) E2(Arg158 --Cys), which is associated with the recessive form of human type III hyperlipoproteinemia (HLP). In transgenic mice fed a norma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31005f8d723c1fb93952e51a325e8bb4
https://doi.org/10.1074/jbc.271.46.29146
https://doi.org/10.1074/jbc.271.46.29146
Publikováno v:
Journal of Biological Chemistry. 269:32368-32372
Despite the definite etiologic link between apolipoprotein (apo) E mutations and type III hyperlipoproteinemia (HLP), it is not clear what additional factors are involved in the development of florid hyperlipidemia and how to explain the wide variabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91c023522053c75a33d388f917a5a35d
https://doi.org/10.1016/s0021-9258(18)31644-2
https://doi.org/10.1016/s0021-9258(18)31644-2
Publikováno v:
Arteriosclerosis and Thrombosis: A Journal of Vascular Biology. 14:1873-1879
Transgenic mice expressing apolipoprotein (apo) E(Cys 142), a human defective variant of apo E, have elevated levels of plasma cholesterol, triglycerides, and very-low-density lipoproteins (VLDL); beta-VLDL, the biochemical hallmark of the human gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98a855678328aad5f2d191e4e9d35b6f
https://doi.org/10.1161/01.atv.14.11.1873
https://doi.org/10.1161/01.atv.14.11.1873
Publikováno v:
Journal of Lipid Research, Vol 35, Iss 3, Pp 408-416 (1994)
Transgenic mouse lines were produced that expressed low levels of a receptor-binding-defective variant of human apolipoprotein (apo) E, apoE(Arg112, Cys142). In transgenic mice, the human apoE was produced only by the kidney, whereas endogenous mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f337cc1fffe6badb5d5a90d58145f825
http://www.sciencedirect.com/science/article/pii/S0022227520411927
http://www.sciencedirect.com/science/article/pii/S0022227520411927
Autor:
Robert W. Mahley, Stanley C. Rall
Publikováno v:
Journal of Internal Medicine. 231:653-659
Apolipoprotein E plays a central role in lipoprotein metabolism by serving as a ligand for the binding of lipoproteins to lipoprotein receptors. Both common and rare variants of apoE have been described. The common variants apoE2 and apoE4 have a sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5884b2319848f0bab80fe0009ebbcf20
https://doi.org/10.1111/j.1365-2796.1992.tb01254.x
https://doi.org/10.1111/j.1365-2796.1992.tb01254.x
Publikováno v:
Journal of Biological Chemistry. 267:6941-6945
The synthesis and secretion of apolipoprotein (apo) E, a major protein component of very low density lipoproteins, were examined in the human hepatoma cell line HepG2 under metabolic conditions known to stimulate lipogenesis and the production of apo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cfcaaca54a268cb13acffe5222aaace
https://doi.org/10.1016/s0021-9258(19)50519-1
https://doi.org/10.1016/s0021-9258(19)50519-1