Palmitoylation of the immunity related GTPase, Irgm1: impact on membrane localization and ability to promote mitochondrial fission.

Autor: Stanley C Henry, Elyse A Schmidt, Michael B Fessler, Gregory A Taylor

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e95021 (2014)

The Immunity-Related GTPases (IRG) are a family of large GTPases that mediate innate immune responses. Irgm1 is particularly critical for immunity to bacteria and protozoa, and for inflammatory homeostasis in the intestine. Although precise functions

Externí odkaz: https://doaj.org/article/023cf6d8a518421c962bd9d7ea94a410

Regulation of macrophage motility by Irgm1

Autor: Maria Traver, Gregory A. Taylor, Maanasa Indaram, Xiaojou Daniell, Stanley C. Henry, Tim Oliver

Publikováno v: Journal of Leukocyte Biology. 87:333-343

Irgm1 controls macrophage motility by regulating the positioning of specific GKS IRG proteins to the plasma membrane, leading to altered Rac activity and actin remodelling. IRG are a family of IFN-regulated proteins that are critical for resistance t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eef161f208a93de8f073536299a1f4e
https://doi.org/10.1189/jlb.0509299

Behavioral characterization of P311 knockout mice

Autor: Robert Kotloski, Ramona M. Rodriguiz, Xiaoju Daniell, Gregory A. Taylor, Lindsey E. Phillips, Robert I. Greene, Stanley C. Henry, Kristy Crooks, William C. Wetsel, Lino Tessarollo

Publikováno v: Genes, Brain and Behavior. 7:786-795

P311 is an 8-kDa protein that is expressed in many brain regions, particularly the hippocampus, cerebellum and olfactory lobes, and is under stringent regulation by developmental, mitogenic and other physiological stimuli. P311 is thought to be invol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4840b4db5b48cf68d0225baa8b99e77
https://doi.org/10.1111/j.1601-183x.2008.00420.x

Palmitoylation of the immunity related GTPase, Irgm1: impact on membrane localization and ability to promote mitochondrial fission

Autor: Gregory A. Taylor, Elyse A. Schmidt, Michael B. Fessler, Stanley C. Henry

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 4, p e95021 (2014)

The Immunity-Related GTPases (IRG) are a family of large GTPases that mediate innate immune responses. Irgm1 is particularly critical for immunity to bacteria and protozoa, and for inflammatory homeostasis in the intestine. Although precise functions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5128a413df6ffbb0e94d224895e144a9
https://pubmed.ncbi.nlm.nih.gov/24751652

IRG and GBP host resistance factors target aberrant, ‘‘Non-self’’ vacuoles characterized by the missing of ‘‘Self’’ IRGM proteins

Autor: Jörn Coers, Joe Dan Dunn, Anthony S. Piro, Arun K. Haldar, Eva M. Frickel, Gregory A. Taylor, Hector Alex Saka, Raphael H. Valdivia, Stanley C. Henry

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS Pathogens
PLoS Pathogens, Vol 9, Iss 6, p e1003414 (2013)

Interferon-inducible GTPases of the Immunity Related GTPase (IRG) and Guanylate Binding Protein (GBP) families provide resistance to intracellular pathogenic microbes. IRGs and GBPs stably associate with pathogen-containing vacuoles (PVs) and elicit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5021694d6b52865589537b6a2e7f4a5
http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003414