Zobrazeno 1 - 10
of 645
pro vyhledávání: '"Stanley B. Prusiner"'
Autor:
Ujjayini Ghosh, Eric Tse, Hyunjun Yang, Marie Shi, Christoffer D. Caro, Feng Wang, Gregory E. Merz, Stanley B. Prusiner, Daniel R. Southworth, Carlo Condello
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-15 (2024)
Abstract Down syndrome (DS) is a common genetic condition caused by trisomy of chromosome 21. Among their complex clinical features, including musculoskeletal, neurological, and cardiovascular disabilities, individuals with DS have an increased risk
Externí odkaz:
https://doaj.org/article/aac87a63fb79463b9e1a637cad62d4a9
Autor:
Gregory E. Merz, Matthew J. Chalkley, Sophia K. Tan, Eric Tse, Joanne Lee, Stanley B. Prusiner, Nick A. Paras, William F. DeGrado, Daniel R. Southworth
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Accumulation of filamentous aggregates of tau protein in the brain is a pathological hallmark of Alzheimer’s disease (AD) and many other neurodegenerative tauopathies. The filaments adopt disease-specific cross-β amyloid conformations tha
Externí odkaz:
https://doaj.org/article/4d453a94c2d04d8b84481f4520c5fd9e
Publikováno v:
Viruses, Vol 16, Iss 3, p 360 (2024)
Theodor (“Ted”) Otto Diener (* 28 February 1921 in Zürich, Switzerland; † 28 March 2023 in Beltsville, MD, USA) pioneered research on viroids while working at the Plant Virology Laboratory, Agricultural Research Service, USDA, in Beltsville. H
Externí odkaz:
https://doaj.org/article/525f4aa56a7d419b8342b9ce39947de4
Autor:
Cedric Lozano, Cristian Ramirez, Ny Sin, Hélène M.-F. Viart, Stanley B. Prusiner, Nick A. Paras, Jay Conrad
Publikováno v:
ACS Omega, Vol 6, Iss 14, Pp 9804-9812 (2021)
Externí odkaz:
https://doaj.org/article/88b235e477554950ac18e5d378cf370e
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-19 (2019)
Abstract Glial cytoplasmic inclusions (GCIs) containing aggregated and hyperphosphorylated α-synuclein are the signature neuropathological hallmark of multiple system atrophy (MSA). Native α-synuclein can adopt a prion conformation that self-propag
Externí odkaz:
https://doaj.org/article/fdf11325c6bf4517942ba4e0d07f7f61
Autor:
T. Peter Lopez, Kurt Giles, Brittany N. Dugger, Abby Oehler, Carlo Condello, Zuzana Krejciova, Julian A. Castaneda, George A. Carlson, Stanley B. Prusiner
Publikováno v:
Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-14 (2017)
Abstract The larger brain of the rat enables a much greater repertoire of complex behaviors than mice, likely making rats preferential for investigating neurodegeneration. Because molecular tools for specific expression of transgenes in the rat brain
Externí odkaz:
https://doaj.org/article/4d2ddaa7092d4483846eb34d52edf9b7
Autor:
George A. Carlson, Stanley B. Prusiner
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4861 (2021)
Although it is not yet universally accepted that all neurodegenerative diseases (NDs) are prion disorders, there is little disagreement that Alzheimer’s disease (AD), Parkinson’s disease, frontotemporal dementia (FTD), and other NDs are a consequ
Externí odkaz:
https://doaj.org/article/a106613f6f1e4870be450bb1f2106d3e
Autor:
Fruma Yehiely, Paul Bamborough, Maria Da Costa, Billie J. Perry, Gopal Thinakaran, Fred E. Cohen, George A. Carlson, Stanley B. Prusiner
Publikováno v:
Neurobiology of Disease, Vol 3, Iss 4, Pp 339-355 (1997)
Prion diseases are disorders of protein conformation that produce neurodegeneration in humans and animals. Studies of transgenic (Tg) mice indicate that a factor designated protein X is involved in the conversion of the normal cellular prion protein
Externí odkaz:
https://doaj.org/article/88c5f85e9c5644c783be20cde95711f4
Autor:
Fruma Yehiely, Paul Bamborough, Maria Da Costa, Billie J. Perry, Gopal Thinakaran, Fred E. Cohen, George A. Carlson, Stanley B. Prusiner
Publikováno v:
Neurobiology of Disease, Vol 10, Iss 1, Pp 67-68 (2002)
Externí odkaz:
https://doaj.org/article/a53344cae47d4386b6978aed2bdc6b86
Autor:
Carlo Condello, Jacob I. Ayers, Clifton L. Dalgard, M. Madhy Garcia Garcia, Brianna M. Rivera, William W. Seeley, Daniel P. Perl, Stanley B. Prusiner
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 120, iss 13
The amyotrophic lateral sclerosis–parkinsonism dementia complex (ALS-PDC) of Guam is an endemic neurodegenerative disease that features widespread tau tangles, occasional α-synuclein Lewy bodies, and sparse β-amyloid (Aβ) plaques distributed in