Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Stanley Adoro"'
Autor:
Xia Liu, Jingjing Yu, Longyong Xu, Katharine Umphred-Wilson, Fanglue Peng, Yao Ding, Brendan M Barton, Xiangdong Lv, Michael Y Zhao, Shengyi Sun, Yuning Hong, Ling Qi, Stanley Adoro, Xi Chen
Publikováno v:
eLife, Vol 10 (2021)
Signals from the pre-T cell receptor and Notch coordinately instruct β-selection of CD4–CD8–double negative (DN) thymocytes to generate αβ T cells in the thymus. However, how these signals ensure a high-fidelity proteome and safeguard the clon
Externí odkaz:
https://doaj.org/article/a0882b95451b420da0b3daebf835253f
Publikováno v:
Blood Cancer Discovery. 4:PR01-PR01
Most patients with acute myeloid leukemia (AML) initially achieve clinical remission after chemotherapy but eventually die from disease relapse as they succumb to chemotherapy-resistant AML cells, including the rare fraction of leukemia stem cells (L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aee867dfd81a3f7f9f55ade7352ae9f4
https://doi.org/10.1158/2643-3249.aml23-pr01
https://doi.org/10.1158/2643-3249.aml23-pr01
Autor:
Dongsu Park, Stanley Adoro, Wei Tong, Takao Iwawaki, Shengyi Sun, Weijie Zhang, Liting Zheng, Tianyuan Hu, Yewei Ji, Kaosheng Lv, Guojun Shi, Jeffrey M. Rosen, Ling Qi, Ge Shang, Laura Ortinau, Yao Ding, Xiang Zhang, Andre Catic, Xia Liu, Longyong Xu, Xi Chen, Tianpeng Gu, Fanglue Peng, Wei Li, Xiangguo Shi, Daisuke Nakada, Jin Wang
Publikováno v:
Nature Cell Biology. 22:1162-1169
Stem cells need to be protected from genotoxic and proteotoxic stress to maintain a healthy pool throughout life1–3. Little is known about the proteostasis mechanism that safeguards stem cells. Here we report endoplasmic reticulum-associated degrad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::caa0cefb17f0324f76c56861cbe0e3cd
https://doi.org/10.1038/s41556-020-00581-x
https://doi.org/10.1038/s41556-020-00581-x
Autor:
Cui Liu, Qiuyun Chen, Yinghui Shang, Lechuang Chen, Jay Myers, Amad Awadallah, Jinger Sun, Shuiliang Yu, Katharine Umphred-Wilson, Danian Che, Yingtong Dou, Luoyi Li, Pamela Wearsch, Diana Ramírez-Bergeron, Rose Beck, Wei Xin, Ge Jin, Stanley Adoro, Lan Zhou
Publikováno v:
Theranostics. 12(6)
The endoplasmic reticulum unfolded protein response (UPR) is a conserved adaptive signaling in ER homeostasis and has emerged as critical in highly proliferating cells and potential treatment target for acute T-cell lymphoblastic leukemia (T-ALL).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcbda6df5e282b7a0f18dcc75ff18c72
https://pubmed.ncbi.nlm.nih.gov/35401837
https://pubmed.ncbi.nlm.nih.gov/35401837
Autor:
Fanglue Peng, Shengyi Sun, Ling Qi, Brendan M Barton, Michael Y Zhao, Xiangdong Lv, Yao Ding, Yuning Hong, Katharine Umphred-Wilson, Xia Liu, Stanley Adoro, Longyong Xu, Xi Chen, Jingjing Yu
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Signals from the pre-T cell receptor and Notch coordinately instruct β-selection of CD4–CD8–double negative (DN) thymocytes to generate αβ T cells in the thymus. However, how these signals ensure a high-fidelity proteome and safeguard the clon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d2e91d1f7bf2695bbc5208a8cd33e67
http://europepmc.org/articles/PMC8315795
http://europepmc.org/articles/PMC8315795
Autor:
Yao Ding, Xia Liu, Longyong Xu, Xiangdong Lv, Shengyi Sun, Yuning Hong, Fanglue Peng, Katharine Umphred-Wilson, Brendan M Barton, Xi Chen, Jingjing Yu, Stanley Adoro, Michael Y Zhao, Ling Qi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eaf8ce914e53a1e70d788c4fbd5748ce
https://doi.org/10.7554/elife.69975.sa2
https://doi.org/10.7554/elife.69975.sa2
Autor:
Jingjing Yu, Stanley Adoro, Yao Ding, Xiangdong Lv, Xia Liu, Fanglue Peng, Longyong Xu, Yuning Hong, Xi Chen, Brendan M Barton, Shengyi Sun, Katharine Umphred-Wilson, Ling Qi, Michael Y Zhao
Signals from the pre-T cell receptor and Notch coordinately instruct β-selection of CD4−CD8− double negative (DN) thymocytes to generate αβ T cells in the thymus. However, how these signals ensure a high-fidelity proteome and safeguard the clo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8355c21411cd1ee3f308f6e98bc5b79
https://doi.org/10.1101/2021.05.06.443041
https://doi.org/10.1101/2021.05.06.443041
Publikováno v:
Cancer Research. 80:LB-047
T-cell acute lymphoblastic leukemia (T-ALL) is a very aggressive hematologic malignancy that results from the transformation of immature T-cell progenitors. Aberrant cell growth and proliferation is sustained by strong oncogenic drivers, notably NOTC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34534792280676865de2f745ccd12614
https://doi.org/10.1158/1538-7445.am2020-lb-047
https://doi.org/10.1158/1538-7445.am2020-lb-047
Publikováno v:
Experimental Hematology. 100:S63
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34e16b94f262f6cea08b4f06f8228b4e
https://doi.org/10.1016/j.exphem.2021.12.263
https://doi.org/10.1016/j.exphem.2021.12.263
Autor:
Ju Han Kim, Raphael Lis, Sarah E. Bettigole, Stanley Adoro, Heewon Seo, Hee Rae Shin, Laurie H. Glimcher, Klaus-Peter Knobeloch, Kwang Hwan Park, Jae-Hyuck Shim
Publikováno v:
Nature Immunology. 18:780-790
The acquisition of a protective vertebrate immune system hinges on the efficient generation of a diverse but self-tolerant repertoire of T cells by the thymus through mechanisms that remain incompletely resolved. Here we identified the endosomal-sort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60539ef1e2315964265d3cc6cce64c81
https://doi.org/10.1038/ni.3764
https://doi.org/10.1038/ni.3764