Zobrazeno 1 - 10
of 285
pro vyhledávání: '"Stanley Pounds"'
Autor:
Quynh T. Tran, Alex Breuer, Tong Lin, Ruth Tatevossian, Sariah J. Allen, Michael Clay, Larissa V. Furtado, Mark Chen, Dale Hedges, Tylman Michael, Giles Robinson, Paul Northcott, Amar Gajjar, Elizabeth Azzato, Sheila Shurtleff, David W. Ellison, Stanley Pounds, Brent A. Orr
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-12 (2024)
Abstract As part of the advancement in therapeutic decision-making for brain tumor patients at St. Jude Children’s Research Hospital (SJCRH), we developed three robust classifiers, a deep learning neural network (NN), k-nearest neighbor (kNN), and
Externí odkaz:
https://doaj.org/article/04b24c66871347abb0fb60d227703a96
Autor:
Abdelrahman H. Elsayed, Xueyuan Cao, Richard J. Marrero, Nam H. K. Nguyen, Huiyun Wu, Yonhui Ni, Raul C. Ribeiro, Herold Tobias, Peter J. Valk, François Béliveau, Guillaume Richard-Carpentier, Josée Hébert, C. Michel Zwaan, Alan Gamis, Edward Anders Kolb, Richard Aplenc, Todd A. Alonzo, Soheil Meshinchi, Jeffrey Rubnitz, Stanley Pounds, Jatinder K. Lamba
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-12 (2024)
Abstract In this study, we leveraged machine-learning tools by evaluating expression of genes of pharmacological relevance to standard-AML chemotherapy (ara-C/daunorubicin/etoposide) in a discovery-cohort of pediatric AML patients (N = 163; NCT001360
Externí odkaz:
https://doaj.org/article/8d2e5546c18f4cf3998b81a1211405a0
Autor:
Sherif Abdelhamed, Melvin E. Thomas III, Tamara Westover, Masayuki Umeda, Emily Xiong, Chandra Rolle, Michael P. Walsh, Huiyun Wu, Jason R. Schwartz, Virginia Valentine, Marcus Valentine, Stanley Pounds, Jing Ma, Laura J. Janke, Jeffery M. Klco
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 21 (2022)
SAMD9 and SAMD9L germline mutations have recently emerged as a new class of predispositions to pediatric myeloid neoplasms. Patients commonly have impaired hematopoiesis, hypocellular marrows, and a greater risk of developing clonal chromosome 7 dele
Externí odkaz:
https://doaj.org/article/8e1fedf5f7604a43996d6f336e9bfb71
Autor:
Jason R. Schwartz, Jing Ma, Jennifer Kamens, Tamara Westover, Michael P. Walsh, Samuel W. Brady, J. Robert Michael, Xiaolong Chen, Lindsey Montefiori, Guangchun Song, Gang Wu, Huiyun Wu, Cristyn Branstetter, Ryan Hiltenbrand, Michael F. Walsh, Kim E. Nichols, Jamie L. Maciaszek, Yanling Liu, Priyadarshini Kumar, John Easton, Scott Newman, Jeffrey E. Rubnitz, Charles G. Mullighan, Stanley Pounds, Jinghui Zhang, Tanja Gruber, Xiaotu Ma, Jeffery M. Klco
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Paediatric therapy-related myeloid neoplasms (tMN) have a dismal prognosis and have not been comprehensively profiled. Here the authors characterise the molecular landscape of 84 paediatric tMN patients, and find that, unlike adult tMNs, these do not
Externí odkaz:
https://doaj.org/article/fe707965968044aaa183257f76774e4d
Autor:
Eric M. Davis, Yu Sun, Yanling Liu, Pandurang Kolekar, Ying Shao, Karol Szlachta, Heather L. Mulder, Dongren Ren, Stephen V. Rice, Zhaoming Wang, Joy Nakitandwe, Alexander M. Gout, Bridget Shaner, Salina Hall, Leslie L. Robison, Stanley Pounds, Jeffery M. Klco, John Easton, Xiaotu Ma
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-18 (2021)
Abstract Background There is currently no method to precisely measure the errors that occur in the sequencing instrument/sequencer, which is critical for next-generation sequencing applications aimed at discovering the genetic makeup of heterogeneous
Externí odkaz:
https://doaj.org/article/b4bdbc0e7ab44eaa83bb934433d4325f
Autor:
Jatinder K. Lamba, Stanley Pounds
Publikováno v:
Haematologica, Vol 107, Iss 10 (2022)
Externí odkaz:
https://doaj.org/article/e16621c68cc748f3aec5149f371f5dc1
Autor:
Rosa Nguyen, Huiyun Wu, Stanley Pounds, Hiroto Inaba, Raul C. Ribeiro, David Cullins, Barbara Rooney, Teresa Bell, Norman J. Lacayo, Kenneth Heym, Barbara Degar, Deborah Schiff, William E. Janssen, Brandon Triplett, Ching-Hon Pui, Wing Leung, Jeffrey E. Rubnitz
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-7 (2019)
Abstract Consolidation therapies for children with intermediate- or high-risk acute myeloid leukemia (AML) are urgently needed to achieve higher cure rates while limiting therapy-related toxicities. We determined if adoptive transfer of natural kille
Externí odkaz:
https://doaj.org/article/4196b54e9163489ba534ba9dc6b66a38
Autor:
Bradley Stockard, Neha Bhise, Miyoung Shin, Joy Guingab-Cagmat, Timothy J. Garrett, Stanley Pounds, Jatinder K. Lamba
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
BackgroundAcute myeloid leukemia (AML) is a hematological malignancy with a dismal prognosis. For over four decades, AML has primarily been treated by cytarabine combined with an anthracycline. Although a significant proportion of patients achieve re
Externí odkaz:
https://doaj.org/article/ccc2c99e8853411d8e049e07fdf750f1
Autor:
Masayuki Umeda, Jing Ma, Tamara Westover, Yonghui Ni, Guangchun Song, Jamie Maciaszek, Michael Rusch, Delaram Rahbarinia, Scott Foy, Benjamin Huang, Michael Walsh, Priyadarshini Kumar, Yanling Liu, Yiping Fan, Gang Wu, Sharyn Baker, Xiaotu Ma, Lu Wang, Jeffrey rubnitz, Stanley Pounds, Jeffery Klco
Recent studies on pediatric acute myeloid leukemia (pAML) have revealed pediatric-specific driver alterations, many of which are underrepresented in the current classification schemas. To comprehensively define the genomic landscape of pAML, we syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bece17ee87b60b08af53b3588ae52bf4
https://doi.org/10.21203/rs.3.rs-2925426/v1
https://doi.org/10.21203/rs.3.rs-2925426/v1
Autor:
Abdelrahman H. Elsayed, Xueyuan Cao, Amit K. Mitra, Huiyun Wu, Susana Raimondi, Christopher Cogle, Zeina Al-Mansour, Raul C. Ribeiro, Alan Gamis, Edward Anders Kolb, Richard Aplenc, Todd A. Alonzo, Soheil Meshinchi, Jeffrey Rubnitz, Stanley Pounds, Jatinder K. Lamba
Publikováno v:
J Clin Oncol
PURPOSE To establish a patient-specific polygenic score derived from cytarabine (ara-C) pathway pharmacogenomic evaluation to personalize acute myeloid leukemia (AML) treatment. MATERIALS AND METHODS Single nucleotide polymorphisms (SNPs) in the ara-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd11c2f0d1bfa183c487fd42f87915c
https://doi.org/10.1200/jco.21.01422
https://doi.org/10.1200/jco.21.01422