Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl-CoA

Autor: Ngo, Jennifer, Choi, Dong Wook, Stanley, Illana A, Stiles, Linsey, Molina, Anthony JA, Chen, Pei-Hsuan, Lako, Ana, Sung, Isabelle Chiao Han, Goswami, Rishov, Kim, Min-Young, Miller, Nathanael, Baghdasarian, Siyouneh, Kim-Vasquez, Doyeon, Jones, Anthony E, Roach, Brett, Gutierrez, Vincent, Erion, Karel, Divakaruni, Ajit S, Liesa, Marc, Danial, Nika N, Shirihai, Orian S

Publikováno v: The EMBO journal, vol 42, iss 11

Changes in mitochondrial morphology are associated with nutrient utilization, but the precise causalities and the underlying mechanisms remain unknown. Here, using cellular models representing a wide variety of mitochondrial shapes, we show a strong

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::bf2b4e59f7973e7d7ae6917737806246
https://escholarship.org/uc/item/9t809202

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl-CoA.

Autor: Ngo J; Division of Endocrinology, Department of Medicine, David Geffen School of Medicine, Molecular Biology Institute, UCLA, CA, Los Angeles, USA.; Department of Molecular and Medical Pharmacology, UCLA, CA, Los Angeles, USA.; Department of Chemistry & Biochemistry, UCLA, CA, Los Angeles, USA.; Molecular Biology Institute, UCLA, CA, Los Angeles, USA., Choi DW; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, MA, Boston, USA.; Department of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon, South Korea., Stanley IA; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, MA, Boston, USA., Stiles L; Division of Endocrinology, Department of Medicine, David Geffen School of Medicine, Molecular Biology Institute, UCLA, CA, Los Angeles, USA.; Department of Molecular and Medical Pharmacology, UCLA, CA, Los Angeles, USA., Molina AJA; Division of Geriatrics and Gerontology, UCSD School of Medicine, CA, La Jolla, USA., Chen PH; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, MA, Boston, USA., Lako A; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, MA, Boston, USA., Sung ICH; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, MA, Boston, USA.; Yale-NUS College, University Town, NUS, Singapore., Goswami R; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, MA, Boston, USA., Kim MY; Department of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon, South Korea., Miller N; Division of Endocrinology, Department of Medicine, David Geffen School of Medicine, Molecular Biology Institute, UCLA, CA, Los Angeles, USA.; Obesity Research Center, Molecular Medicine, Boston University School of Medicine, MA, Boston, USA., Baghdasarian S; Division of Endocrinology, Department of Medicine, David Geffen School of Medicine, Molecular Biology Institute, UCLA, CA, Los Angeles, USA., Kim-Vasquez D; Division of Endocrinology, Department of Medicine, David Geffen School of Medicine, Molecular Biology Institute, UCLA, CA, Los Angeles, USA., Jones AE; Department of Molecular and Medical Pharmacology, UCLA, CA, Los Angeles, USA., Roach B; Division of Endocrinology, Department of Medicine, David Geffen School of Medicine, Molecular Biology Institute, UCLA, CA, Los Angeles, USA., Gutierrez V; Division of Endocrinology, Department of Medicine, David Geffen School of Medicine, Molecular Biology Institute, UCLA, CA, Los Angeles, USA., Erion K; Division of Endocrinology, Department of Medicine, David Geffen School of Medicine, Molecular Biology Institute, UCLA, CA, Los Angeles, USA., Divakaruni AS; Department of Molecular and Medical Pharmacology, UCLA, CA, Los Angeles, USA., Liesa M; Division of Endocrinology, Department of Medicine, David Geffen School of Medicine, Molecular Biology Institute, UCLA, CA, Los Angeles, USA.; Department of Molecular and Medical Pharmacology, UCLA, CA, Los Angeles, USA.; Molecular Biology Institute, UCLA, CA, Los Angeles, USA.; Molecular Biology Institute of Barcelona, IBMB-CSIC, Barcelona, Spain., Danial NN; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, MA, Boston, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, MA, Boston, USA.; Department of Medicine, Harvard Medical School, MA, Boston, USA., Shirihai OS; Division of Endocrinology, Department of Medicine, David Geffen School of Medicine, Molecular Biology Institute, UCLA, CA, Los Angeles, USA.; Department of Molecular and Medical Pharmacology, UCLA, CA, Los Angeles, USA.

Publikováno v: The EMBO journal [EMBO J] 2023 Jun 01; Vol. 42 (11), pp. e111901. Date of Electronic Publication: 2023 Mar 14.