Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Stanko Skrtic"'
Autor:
Claudia S. Cabrera, Alison S. Lee, Marita Olsson, Volker Schnecke, Klara Westman, Marcus Lind, Peter J. Greasley, Stanko Skrtic
Publikováno v:
Kidney International Reports, Vol 5, Iss 10, Pp 1651-1660 (2020)
Introduction: It remains unclear whether an increased progression rate of chronic kidney disease (CKD) adds predictive information regarding cardiovascular disease (CVD) risk. The aim of this study was to evaluate the association between CKD progress
Externí odkaz:
https://doaj.org/article/25cf5e66c41a48909bac599e2171e8cd
Autor:
Victor Sokolov, Gabriel Helmlinger, Catarina Nilsson, Kirill Zhudenkov, Stanko Skrtic, Bengt Hamrén, Kirill Peskov, Eva Hurt-Camejo, Rasmus Jansson-Löfmark
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 9, Pp 1610-1621 (2019)
Since the discovery of proprotein convertase subtilisin/kexin type 9 (PCSK9) as an attractive target in the treatment of hypercholesterolemia, multiple anti-PCSK9 therapeutic modalities have been pursued in drug development. The objective of this res
Externí odkaz:
https://doaj.org/article/bd39b188292347dca7350be24e8f0568
Autor:
Marco Cavalli, Nicholas Baltzer, Gang Pan, José Ramón Bárcenas Walls, Karolina Smolinska Garbulowska, Chanchal Kumar, Stanko Skrtic, Jan Komorowski, Claes Wadelius
Publikováno v:
Human Genomics, Vol 13, Iss 1, Pp 1-8 (2019)
Abstract Background Genome-wide association studies (GWAS) of diseases and traits have found associations to gene regions but not the functional SNP or the gene mediating the effect. Difference in gene regulatory signals can be detected using chromat
Externí odkaz:
https://doaj.org/article/b886c2ddfcee404e937050aea5969752
Autor:
Mahabuba Jahan, Peter Johnström, Ram K. Selvaraju, Marie Svedberg, Maria Sörhede Winzell, Jenny Bernström, Lee Kingston, Magnus Schou, Zhisheng Jia, Stanko Skrtic, Lars Johansson, Olle Korsgren, Lars Farde, Christer Halldin, Olof Eriksson
Publikováno v:
EJNMMI Research, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract Background The G-protein-coupled receptor 44 (GPR44) is a beta cell-restricted target that may serve as a marker for beta cell mass (BCM) given the development of a suitable PET ligand. Methods The binding characteristics of the selected can
Externí odkaz:
https://doaj.org/article/adeebd397411476c89f34e68e0105f08
Autor:
Dimitrios Chantzichristos, Per-Arne Svensson, Terence Garner, Camilla AM Glad, Brian R Walker, Ragnhildur Bergthorsdottir, Oskar Ragnarsson, Penelope Trimpou, Roland H Stimson, Stina W Borresen, Ulla Feldt-Rasmussen, Per-Anders Jansson, Stanko Skrtic, Adam Stevens, Gudmundur Johannsson
Publikováno v:
eLife, Vol 10 (2021)
Background: Glucocorticoids are among the most commonly prescribed drugs, but there is no biomarker that can quantify their action. The aim of the study was to identify and validate circulating biomarkers of glucocorticoid action. Methods: In a rando
Externí odkaz:
https://doaj.org/article/2fd4e8ec41fc4f27b347cd69da834ac2
Publikováno v:
iScience, Vol 23, Iss 2, Pp - (2020)
Summary: Long-chain polyunsaturated fatty acids (LC-PUFAs) influence human health in several areas, including cardiovascular disease, diabetes, fatty liver disease, and cancer. ELOVL2 encodes one of the key enzymes in the in vivo synthesis of LC-PUFA
Externí odkaz:
https://doaj.org/article/086bb7c3153e48ddad39eb960e84dfb1
Autor:
Assel Sarsenbayeva, Bipasha Nandi Jui, Giovanni Fanni, Pedro Barbosa, Fozia Ahmed, Robin Kristófi, Jing Cen, Azazul Chowdhury, Stanko Skrtic, Peter Bergsten, Tove Fall, Jan W. Eriksson, Maria J. Pereira
Publikováno v:
Metabolites, Vol 11, Iss 9, p 574 (2021)
Inhibition of 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase is associated with an increased risk of new-onset type 2 diabetes. We studied the association of genetic or pharmacological HMG-CoA reductase inhibition with plasma and adipose tissue
Externí odkaz:
https://doaj.org/article/7fa54f4ef2d6451783b2294999d68808
Autor:
Stanko Skrtic, Björn Tyrberg, Malin Broberg, Hans Ericsson, Volker Schnecke, Magnus Kjaer, Marcus Hompesch, Eva-Marie Andersson, Erik Ryberg, Alexander Aivazidis, Charlotte Wennberg Huldt, Lars Löfgren, Linda Morrow, Joanna Parkinson, Tina Rydén-Bergsten, Elaine Watkins, Maria Sörhede Winzell
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0208998 (2018)
AIMS/HYPOTHESIS:GPR44 (DP2, PTGDR2, CRTh2) is the receptor for the pro-inflammatory mediator prostaglandin D2 (PGD2) and it is enriched in human islets. In rodent islets, PGD2 is produced in response to glucose, suggesting that the PGD2-GPR44/DP2 axi
Externí odkaz:
https://doaj.org/article/14eb9641fd434a2fbeda8df2991ce6e8
Autor:
Sara F Hansson, Alex-Xianghua Zhou, Paulina Vachet, Jan W Eriksson, Maria J Pereira, Stanko Skrtic, Helen Jongsma Wallin, Anders Ericsson-Dahlstrand, Daniel Karlsson, Andrea Ahnmark, Maria Sörhede Winzell, Maria Chiara Magnone, Pia Davidsson
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0196601 (2018)
Beta cell dysfunction accompanies and drives the progression of type 2 diabetes mellitus (T2D), but there are few clinical biomarkers available to assess islet cell stress in humans. Secretagogin, a protein enriched in pancreatic islets, demonstrates
Externí odkaz:
https://doaj.org/article/9ceaca4506cf4aae8dab9aeb64a7c0da
Autor:
Afaf Sahraoui, Maria Sörhede Winzell, Tracy Gorman, Dave M Smith, Stanko Skrtic, Merete Hoeyem, Shadab Abadpour, Lars Johansson, Olle Korsgren, Aksel Foss, Hanne Scholz
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121204 (2015)
Islet transplantation has become a viable clinical treatment, but is still compromised by long-term graft failure. Exendin-4, a glucagon-like peptide 1 receptor agonist, has in clinical studies been shown to improve insulin secretion in islet transpl
Externí odkaz:
https://doaj.org/article/afc7bcf990de45488994a0387f892839