A Fast Scoring of Human Primary Respiratory Epithelia Grown at Air-Liquid Interface (ALI) to Assess Epithelial Morphology in Research and Personalized Medicine Settings.

Autor: Lutsch CT; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, 30625 Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), 30625 Hannover, Germany., Feng L; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, 30625 Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), 30625 Hannover, Germany., Gómez Hohn A; Institute for Pathology, Hannover Medical School, 30625 Hannover, Germany., Brandt L; Institute for Pathology, Hannover Medical School, 30625 Hannover, Germany., Tamm S; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, 30625 Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), 30625 Hannover, Germany., Janciauskiene S; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), 30625 Hannover, Germany.; Department of Respiratory Medicine, Hannover Medical School, 30625 Hannover, Germany., Stanke F; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, 30625 Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), 30625 Hannover, Germany., Jonigk D; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), 30625 Hannover, Germany.; Institute of Pathology, School of Medicine, University Hospital RWTH Aachen, 52074 Aachen, Germany., Dittrich AM; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, 30625 Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), 30625 Hannover, Germany., Braubach P; Institute for Pathology, Hannover Medical School, 30625 Hannover, Germany.

Publikováno v: Journal of personalized medicine [J Pers Med] 2024 Jan 18; Vol. 14 (1). Date of Electronic Publication: 2024 Jan 18.

Changes in cystic fibrosis transmembrane conductance regulator protein expression prior to and during elexacaftor-tezacaftor-ivacaftor therapy.

Autor: Stanke F; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research, Hannover Medical School, Hannover, Germany., Pallenberg ST; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany., Tamm S; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research, Hannover Medical School, Hannover, Germany., Hedtfeld S; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany., Eichhorn EM; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany., Minso R; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany., Hansen G; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research, Hannover Medical School, Hannover, Germany., Welte T; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research, Hannover Medical School, Hannover, Germany.; Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany., Sauer-Heilborn A; Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany., Ringshausen FC; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research, Hannover Medical School, Hannover, Germany.; Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany., Junge S; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany., Tümmler B; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research, Hannover Medical School, Hannover, Germany., Dittrich AM; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research, Hannover Medical School, Hannover, Germany.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2023 Jan 27; Vol. 14, pp. 1114584. Date of Electronic Publication: 2023 Jan 27 (Print Publication: 2023).

Mukoviszidose - eine pleiotrope Ionenkanalerkrankung mit wesentlicher Lungenbeteiligung.

Autor: Stanke, F.¹, Tümmler, B.¹, Stuhrmann, M.² stuhrmann.manfred@mh-hannover.de

Publikováno v: Medizinische Genetik. Dec2013, Vol. 25 Issue 4, p486-492. 7p.

Generation of two TMEM16A knockout iPSC clones each from a healthy human iPSC line, from a Cystic Fibrosis patient specific line with p.Phe508del mutation and from the gene corrected iPSC line.

Autor: Jaboreck MC; Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery (HTTG), Hannover Medical School, 30625 Hannover, Germany; Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Member of the German Center for Lung Research (DZL), Hannover Medical School, 30625 Hannover, Germany; REBIRTH-Research Center for Translational and Regenerative Medicine, Hannover Medical School, 30625 Hannover, Germany., Lühmann JL; Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery (HTTG), Hannover Medical School, 30625 Hannover, Germany; Department of Human Genetics, Hannover Medical School, 30625 Hannover, Germany., Mielenz M; Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Member of the German Center for Lung Research (DZL), Hannover Medical School, 30625 Hannover, Germany; Clinic for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, 30625 Hannover, Germany., Stanke F; Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Member of the German Center for Lung Research (DZL), Hannover Medical School, 30625 Hannover, Germany; Clinic for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, 30625 Hannover, Germany., Göhring G; REBIRTH-Research Center for Translational and Regenerative Medicine, Hannover Medical School, 30625 Hannover, Germany; Department of Human Genetics, Hannover Medical School, 30625 Hannover, Germany., Martin U; Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery (HTTG), Hannover Medical School, 30625 Hannover, Germany; Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Member of the German Center for Lung Research (DZL), Hannover Medical School, 30625 Hannover, Germany; REBIRTH-Research Center for Translational and Regenerative Medicine, Hannover Medical School, 30625 Hannover, Germany., Olmer R; Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery (HTTG), Hannover Medical School, 30625 Hannover, Germany; Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Member of the German Center for Lung Research (DZL), Hannover Medical School, 30625 Hannover, Germany; REBIRTH-Research Center for Translational and Regenerative Medicine, Hannover Medical School, 30625 Hannover, Germany., Merkert S; Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery (HTTG), Hannover Medical School, 30625 Hannover, Germany; Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Member of the German Center for Lung Research (DZL), Hannover Medical School, 30625 Hannover, Germany; REBIRTH-Research Center for Translational and Regenerative Medicine, Hannover Medical School, 30625 Hannover, Germany. Electronic address: merkert.sylvia@mh-hannover.de.

Publikováno v: Stem cell research [Stem Cell Res] 2022 Oct; Vol. 64, pp. 102918. Date of Electronic Publication: 2022 Sep 14.

Disease-related blood-based differential methylation in cystic fibrosis and its representation in lung cancer revealed a regulatory locus in PKP3 in lung epithelial cells.

Autor: Schamschula E; Department of Biosciences, University of Salzburg, Salzburg, Austria., Lahnsteiner A; Department of Biosciences, University of Salzburg, Salzburg, Austria., Assenov Y; Division of Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Hagmann W; Division of Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Zaborsky N; Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Salzburg Cancer Research Institute - Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR), Paracelsus Medical University, Salzburg, Austria.; Cancer Cluster Salzburg, Salzburg, Austria., Wiederstein M; Department of Biosciences, University of Salzburg, Salzburg, Austria., Strobl A; Department of Biosciences, University of Salzburg, Salzburg, Austria., Stanke F; Clinical Research Group, Clinic for Pediatric Pneumology, Allergology and Neonatology, Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research, Hannover Medical School, Hannover, Germany., Muley T; Translational Research Unit, Thoraxklinik Heidelberg, University of Heidelberg, Germany.; Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg, Germany., Plass C; Division of Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg, Germany., Tümmler B; Clinical Research Group, Clinic for Pediatric Pneumology, Allergology and Neonatology, Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research, Hannover Medical School, Hannover, Germany., Risch A; Department of Biosciences, University of Salzburg, Salzburg, Austria.; Division of Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Cancer Cluster Salzburg, Salzburg, Austria.; Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg, Germany.

Publikováno v: Epigenetics [Epigenetics] 2022 Aug; Vol. 17 (8), pp. 837-860. Date of Electronic Publication: 2021 Aug 20.