Zobrazeno 1 - 10 of 99 pro vyhledávání: '"Stanislaw Rachwal"'
1
Benzotriazinone and benzopyrimidinone derivatives as potent positive allosteric AMPA receptor modulators
Autor: Todd Herbst, Stanislaw Rachwal, Sheng Zhong, Lee Steven, Peter E. Haroldsen, Rudolf Mueller, Leslie J. Street, Yong-Xin Li, Mark A. Varney, Gary A. Rogers, Steven W. Johnson, Susan Tanimura
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 21:6170-6175
AMPA receptors (AMPARs) have been demonstrated to be an important therapeutic CNS target. A series of substituted benzotriazinone and benzopyrimidinone derivatives were prepared with the aim to improve in vivo activity over the previously reported bi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3663a98e7b3e34a0dc3c1a46155fd80e
https://doi.org/10.1016/j.bmcl.2011.07.098
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2
Benzoxazinones as potent positive allosteric AMPA receptor modulators: Part I
Autor: Yong-Xin Li, Harris Clayton, Stanislaw Rachwal, Marrs Christopher M, Lena Nielsson, Aidan Hampson, Gary A. Rogers, Rudolf Mueller, Jolanta Ulas, Sheng Zhong
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 21:3923-3926
AMPA receptors (AMPARs) are an increasingly important therapeutic target in the CNS. Aniracetam, the first identified potentiator of AMPARs, led to the rigid and more potent CX614. This lead molecule was optimized in order to increase affinity toward
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db864108440f49374bc4140e91de1fe3
https://doi.org/10.1016/j.bmcl.2011.05.026
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3
Preparation of dyes derived from Eriochrome Red B and Acid Alizarin Violet N soluble in organic solvents
Autor: Alan R. Katritzky, David W. Macomber, Terrance P. Smith, Bogumila Rachwal, Stanislaw Rachwal
Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 112:552-556
Both hydroxy groups of Eriochrome Red B are protected by acetylation and the sulfonic acid group is converted to the sulfonyl chloride with phosphorus pentachloride. Reaction with dibutylamine or N-butylbenzeneethanamine followed by the deprotection
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85e840048482cc657e396a3c4df7fcaf
https://doi.org/10.1002/recl.19931121007
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4
Design, synthesis, and discovery of 5-piperazinyl-1,2,6,7-tetrahydro-5H-azepino[3,2,1-hi]indol-4-one derivatives: A novel series of mixed dopamine D2/D4 receptor antagonist
Autor: Jack Hammer, He Zhao, Charles J. Manly, Robbin Brodbeck, Renee Primus, Andrzej Kieltyka, Andrew Thurkauf, Jayaraman Chandrasekhar, Stanislaw Rachwal, Xiaoyan Zhang, Kevin J. Hodgetts
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 13:701-704
5-piperazinyl-1,2,6,7-tetrahydro-5H-azepino[3,2,1-hi]indol-4-one derivatives were designed, synthesized, and identified as a new series of mixed dopamine D(2)/D(4) receptor antagonists. This series featured a rigid tricyclic ring system as an importa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d838ce696cd6b9f68c9b403a0901ae31
https://doi.org/10.1016/s0960-894x(02)01056-9
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5
Indoline and piperazine containing derivatives as a novel class of mixed D2/D4 receptor antagonists. Part 1: Identification and structure–activity relationships
Autor: Hutchison Alan J, Kover Renata X, Robbin Brodbeck, Xiao-Shu He, Andrew Thurkauf, Kevin J. Hodgetts, Andrzej Kieltyka, Stanislaw Rachwal, Xiaoyan Zhang, John R. Peterson, Jan W. F. Wasley, Renee J. Primus, He Zhao
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 12:3105-3109
Optimization of the lead compound 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2,3-dihydro-indol-1-yl)-ethanone 1 by systematic structure-activity relation (SAR) studies lead to two potent compounds 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2-methy-2,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb02ce198fbc302c0f8d14590d286292
https://doi.org/10.1016/s0960-894x(02)00655-8
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6
trans-1-[(2-Phenylcyclopropyl)methyl]-4-arylpiperazines: Mixed Dopamine D2/D4 Receptor Antagonists as Potential Antipsychotic Agents
Autor: Maria D. Bacolod, Andrew Thurkauf, Xiaoyan Zhang, Andrzej Kieltyka, Jennifer Tran, Jan W. F. Wasley, He Zhao, Robbin Brodbeck, Brian Girard, Kevin J. Hodgetts, Diane C. Hoffman, Kimberly Craven, Stanislaw Rachwal
Publikováno v: Journal of Medicinal Chemistry. 43:3923-3932
The dopaminergic receptor profile of a series of trans-1-[(2-phenylcyclopropyl)methyl]-4-arylpiperazines was examined. Aromatic substitution patterns were varied with the goal of identifying a compound having affinities for the D(2) and D(4) receptor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ebbd3228b62f4930f7bbde7a791a72
https://doi.org/10.1021/jm990562x
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8
Full length article
Autor: J. Vlasak, Pascal Druzgala, Z Z Liu, Stanislaw Rachwal, Emil Pop, Marcus E. Brewster
Publikováno v: Steroids. 63:193-201
Several derivatives of lotoprednol etabonate (1), a soft corticosteroid antiinflammatory drug, are formed during the synthesis and sterilization process. Some of these contaminants of 1 result from side reactions taking place on the steroid ring C in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e6d5312235594576d923f43a6599702
https://doi.org/10.1016/s0039-128x(98)00003-8
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