Helping proteins come in from the cold: 5 burning questions about cold-active enzymes

Autor: Jan Stanislaw Nowak, Daniel E. Otzen

Publikováno v: BBA Advances, Vol 5, Iss , Pp 100104- (2024)

Enzymes from psychrophilic (cold-loving) organisms have attracted considerable interest over the past decades for their potential in various low-temperature industrial processes. However, we still lack large-scale commercialization of their activitie

Externí odkaz: https://doaj.org/article/d1f149f9fd174f839d44a5217386627a

Balance control of the orthostatic body pose in physical education of students

Autor: Ihor Zanevskyy, Stanislaw Nowak

Publikováno v: Physical Education of Students, Vol 24, Iss 1, Pp 63-70 (2020)

Background and Study Aim. Maintaining upright body posture is fundamental for humans. The aim of the research is to determine influence of the feet situation on the balance of the orthostatic body pose in physical education. Material and Methods.

Externí odkaz: https://doaj.org/article/c0495a7d29f4401eb3f2e5ae865cb381

1446 Multiplexed ion beam imaging identifies B-cell enrichment in the RHAMM-high invasive niche of breast cancer

Autor: Yuyu He, Grant Barthel, Raghav Padmanabhan, Colleen Forster, Hanna Root, Mate Nagy, Stanislaw Nowak, James McCarthy, Kathryn Schwertfeger, Andrew Nelson

Publikováno v: Regular and Young Investigator Award Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9c65f1eb043c6f43a1dc6eb35e06c41
https://doi.org/10.1136/jitc-2022-sitc2022.1446

Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential

Autor: Prakruti Rabadia, Benoit I. Giasson, Sissel Ida Schmidt, Emil Gregersen, Daniel E. Otzen, Nicolas Mendez, Katarina Willén, Marina Romero-Ramos, Cristine Betzer, Zachary A. Sorrentino, Nelson Ferreira, Mingdong Dong, Morten Meyer, Kaare Bjerregaard-Andersen, Clara Perez-Gozalbo, Ümit Akbey, Mohammad Shahnawaz, Jie Wang, Marjo Beltoja, Jan Stanislaw Nowak, Lasse Reimer, Ersoy Cholak, Poul Henning Jensen, Hjalte Gram, Claudio Soto, Madhu Nagaraj

Publikováno v: Acta Neuropathologica
Ferreira, N, Gram, H, Sorrentino, Z A, Gregersen, E, Schmidt, S I, Reimer, L, Betzer, C, Perez-Gozalbo, C, Beltoja, M, Nagaraj, M, Wang, J, Nowak, J S, Dong, M, Willén, K, Cholak, E, Bjerregaard-Andersen, K, Mendez, N, Rabadia, P, Shahnawaz, M, Soto, C, Otzen, D E, Meyer, M, Giasson, B I, Romero-Ramos, M & Jensen, P H 2021, ' Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential ', Acta Neuropathologica, vol. 142, pp. 87-115 . https://doi.org/10.1007/s00401-021-02316-0
Ferreira, N, Gram, H, Sorrentino, Z A, Gregersen, E, Schmidt, S I, Reimer, L, Betzer, C, Perez-Gozalbo, C, Beltoja, M, Nagaraj, M, Wang, J, Nowak, J S, Dong, M, Willén, K, Cholak, E, Bjerregaard-Andersen, K, Mendez, N, Rabadia, P, Shahnawaz, M, Soto, C, Otzen, D E, Akbey, Ü, Meyer, M, Giasson, B I, Romero-Ramos, M & Jensen, P H 2021, ' Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential ', Acta Neuropathologica, vol. 142, no. 1, pp. 87-115 . https://doi.org/10.1007/s00401-021-02316-0

Pathology consisting of intracellular aggregates of alpha-Synuclein (α-Syn) spread through the nervous system in a variety of neurodegenerative disorders including Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy. The di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ef2ee32f1b8c2ffae01900379642ce
http://europepmc.org/articles/PMC8217051

Quantitating denaturation by formic acid: Imperfect repeats are essential to the stability of the functional amyloid protein FapC

Autor: Thorbjørn Vincent Sønderby, Signe Andrea Frank, Daniel E. Otzen, Line Friis Bakmann Christensen, Jan Stanislaw Nowak

Publikováno v: The journal of Biological Chemistry
J Biol Chem
Christensen, L F B, Nowak, J S, Sønderby, T V, Frank, S A & Otzen, D E 2020, ' Quantitating denaturation by formic acid : Imperfect repeats are essential to the stability of the functional amyloid protein FapC ', The Journal of biological chemistry, vol. 295, no. 37, pp. 13031–13046 . https://doi.org/10.1074/jbc.RA120.013396

Bacterial functional amyloids are evolutionarily optimized to aggregate to help them fulfil their biological functions,e.g.to provide mechanical stability to biofilm. Amyloid is formed inPseudomonassp. by the protein FapC which contains 3 imperfect r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d20383db4daeb28d88fd6d5b71ee3d